{"text_format":"1","workbook":"xlsx","n_sheets":17,"sheets":["Instructions","LookUp","LinkAB","LinkYZMammals","LinkYZFish","LinkYZAmphibian","LinkYZAvian","LinkInVitro","Interpretation","Data_RMS","Data summary_RMS","Lines of evidence_RMS","Data_APPL","Data summary-APPL","LoE-Adversity_APPL","LOE-EAS activity_APPL","LoE-T activity_APPL"],"not_rendered":{"charts":0,"images":0,"macros":1,"external_links":0,"defined_names":45,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"Instructions","index":0,"n_rows":4,"n_cols":14,"rows_kept":4,"cut":false,"hidden":true,"merged":[]}
["Instructions of use",null,null,null,null,null,null,null,null,null,null,null,"OLD","NEW"]
[null,null,null,null,null,null,null,null,null,null,null,"names management rules",70,27]
[null,"New occurrences on Y column"]
[null,"Add a sheet and name it as \"LinkYZnew"]

{"sheet":"LookUp","index":1,"n_rows":19,"n_cols":9,"rows_kept":19,"cut":false,"hidden":true,"merged":[]}
["LookUp Column","L","N","O","S","U","V","AD"]
["Header","Sex (administration)","Route of administration","Method of administration","Dose unit","Duration unit","Generation/Life stage","Effect direction","Relevance"]
[null,"M","Oral","Feed","mg/kg bw/day","Minutes","Adult","Increase","Yes"]
[null,"F","Inhalation","Gavage/Intubation","mg/L water","Hours","Adult (P1)","Decrease","No"]
[null,"M + F","Dermal","Whole-Body","mg/L","Days","Adult (F0)","Change","N/A"]
[null,null,"Direct","Capsule","µg ai/L","Weeks","Adult (F1)","Induction"]
[null,null,"Uptake from water","Water","Molar","Months","Adult (F2)","No effect"]
[null,null,"Uptake from the medium (in vitro)","Topical","ppm","Years","Adult (F0+F1)"]
[null,null,"[Not in list]","Not specified","µM",null,"Offspring (F1)"]
[null,null,null,"Subcutaneous","other",null,"Offspring (F2)"]
[null,null,null,"Intravenous",null,null,"Offspring (F3)"]
[null,null,null,"Nose only",null,null,"Offspring (F1+F2)"]
[null,null,null,"[Not in list]",null,null,"Fetus"]
[null,null,null,null,null,null,"Embryo"]
[null,null,null,null,null,null,"Larval"]
[null,null,null,null,null,null,"Juvenile"]
[null,null,null,null,null,null,"Tadpole"]
[null,null,null,null,null,null,"Eggs"]
[null,null,null,null,null,null,"[Not in list]"]

{"sheet":"LinkAB","index":2,"n_rows":32,"n_cols":15,"rows_kept":32,"cut":false,"hidden":true,"merged":[]}
["Column A","Column B Study principle","Column B Study principle","Column B Study principle","Column B Study principle","Column B Study principle","Column B Study principle","Column B Study principle","Column B Study principle","Column B Study principle","Column B Study principle","Column B Study principle","Column B Study principle","Column B Study principle","Column B Study principle"]
["TypeOfToxicity","Mammals","Fish","Amphibian","Avian","InVitroEstrogen","InVitroAndrogen","InVitroThyroid","InVitroSteroidogenesis","InVitroToxCast Estrogen","InVitroToxCast Androgen","InVitroToxCast Thyroid","InVitroToxCast Steroidogenesis","InVitroHepatocytes","InVitroGeneral"]
[null,"Adult male assay","Fish short-term reproduction assay","Amphibian metamorphosis assay","Avian reproduction test","ER Binding Assay","AR Binding Assay","TR binding assay","H295R steroidogenesis assay","ToxCast ER prediction model","ToxCast AR prediction model","ATG_THRa1_TRANS_up","NVS_ADME_hCYP19A1","In vitro hepatocytes","In vitro method (general)"]
[null,"Carcinogenicity","21-day fish assay","Xenopus embryonic thyroid signalling assay XETA","US EPA avian two-generation study","Stably Transfected Human ERα Transcriptional Activation Assay (ER STTA)","Stably Transfected Human AR Transactivation Assay (AR STTA)","Other TR in vitro assay","Aromatase Assay","NVS_NR_bER","ATG_AR_TRANS_up","NVS_NR_hTRa","TOX21_Aromatase_Inhibition"]
[null,"Chronic toxicity","Androgenised female stickleback screen","Larval amphibian growth and development assay","Avian Not il list","BG1Luc Estrogen Receptor Transactivation Assay","Other AR in vitro assay",null,"Other Steroidogenesis in vitro assay","NVS_NR_hER","NVS_NR_cAR","Tox21_TR_LUC_GH3_Agonist","CEETOX_H295R_11DCORT_dn"]
[null,"Combined chronic toxicity/carcinogenicity studies","EASZY assay","Amphibian Not il list",null,"Other ER in vitro assay",null,null,null,"NVS_NR_mERa","NVS_NR_hAR","Tox21_TR_LUC_GH3_Antagonist","CEETOX_H295R_OHPREG_dn"]
[null,"Combined\nrepeated dose toxicity study with the reproduction/developmental toxicity screening test","Juvenile medaka anti-androgen screening assay",null,null,null,null,null,null,"OT_ER_ERaERa_0480","NVS_NR_rAR",null,"CEETOX_H295R_OHPREG_up"]
[null,"Developmental neurotoxicity study","Rapid androgen disruption adverse outcome reporter assay",null,null,null,null,null,null,"OT_ER_ERaERa_1440","OT_AR_ARELUC_AG_1440",null,"CEETOX_H295R_OHPROG_dn"]
[null,"Extended one-generation reproductive toxicity study","Fish sexual development test",null,null,null,null,null,null,"OT_ER_ERaERb_048","OT_AR_ARSRC1_0480",null,"CEETOX_H295R_ANDR_dn"]
[null,"Female pubertal assay (PP Female Assay)","Medaka extended one-generation reproduction test",null,null,null,null,null,null,"OT_ER_ERaERb_1440","OT_AR_ARSRC1_0960",null,"CEETOX_H295R_CORTISOL_dn"]
[null,"Fertility (Segment I)","Fish life cycle toxicity test",null,null,null,null,null,null,"OT_ER_ERbERb_0480","Tox21_AR_BLA_Agonist_ratio",null,"CEETOX_H295R_DOC_dn"]
[null,"Hershberger assay","Fish reproduction partial lifecycle test",null,null,null,null,null,null,"OT_ER_ERbERb_1440","Tox21_AR_BLA_Antagonist_ratio",null,"CEETOX_H295R_ESTRADIOL_dn"]
[null,"Male pubertal assay (PP Male Assay)","Fish early life stage toxicity test",null,null,null,null,null,null,"OT_ERa_EREGFP_0120","Tox21_AR_LUC_MDAKB2_Agonist",null,"CEETOX_H295R_ESTRONE_dn"]
[null,"Multigenerational reproductive toxicity","Fish Not il list",null,null,null,null,null,null,"OT_ERa_EREGFP_0480","Tox21_AR_LUC_MDAKB2_Antagonist",null,"CEETOX_H295R_PROG_dn"]
[null,"One-generation reproduction toxicity study",null,null,null,null,null,null,null,"ATG_ERa_TRANS_up",null,null,"CEETOX_H295R_PROG_up"]
[null,"Peripubertal male and female assays",null,null,null,null,null,null,null,"ATG_ERE_CIS_up",null,null,"CEETOX_H295R_TESTO_dn"]
[null,"Prenatal developmental toxicity study",null,null,null,null,null,null,null,"Tox21_ERa_BLA_Agonist_ratio"]
[null,"Repeated dose 28-day oral toxicity study in non-rodents",null,null,null,null,null,null,null,"Tox21_ERa_LUC_BG1_Agonist"]
[null,"Repeated dose 28-day oral toxicity study in rodents",null,null,null,null,null,null,null,"ACEA_T47D_80 h"]
[null,"Repeated dose 90-day oral toxicity study in non-rodents",null,null,null,null,null,null,null,"Tox21_ERa_BLA_Antagonist_ratio"]
[null,"Repeated dose 90-day oral toxicity study in rodents",null,null,null,null,null,null,null,"Tox21_ERa_LUC_BG1_Antagonist"]
[null,"Repeated dose dermal toxicity"]
[null,"Reproduction/developmental toxicity screening test"]
[null,"Subacute inhalation toxicity"]
[null,"Subacute oral in non-rodent "]
[null,"Subacute oral in rodent "]
[null,"Subchronic oral toxicity in rodents"]
[null,"Subchronic \ninhalation toxicity: 90-day study"]
[null,"Subchronic dermal toxicity: 90-day study"]
[null,"Two-generation reproduction toxicity test"]
[null,"Uterotrophic assay"]
[null,"Mammals Not il list"]

{"sheet":"LinkYZMammals","index":3,"n_rows":51,"n_cols":9,"rows_kept":51,"cut":false,"hidden":true,"merged":[]}
["Column Y","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target"]
["Effect type","In life observation","Organ Weight","Organ histopathology","Reproductive","Developmental","Abnormalities","Clinical chemistry/hormones","No relevant effect observed"]
[null,"Body weight","Adrenals weight","Accessory sex organs histopathology","Age at balanopreputial separation","Auditory startle","Ano-Genital distance","Estradiol level","No relevant effect observed"]
[null,"Clinical chemistry and haematology","Adrenals weight (Hershberger)","Adrenals histopathology","Age at first estrus","Brain morphometric (quantitative) evaluation","Genital abnormalities","Follicle Stimulating Hormone (FSH) level"]
[null,"Clinical signs","Brain weight","Aorta histopathology","Age at Vaginal opening","Fetal development","Nipple Development","HDL/LDL ratio (considered T-mediated only in combination with other thyroid endpoints)"]
[null,"Food consumption","Coagulating gland weight","Bone histopathology","Dystocia","Functional observation battery","Presence of anomalies (external, visceral, skeletal","Luteinizing Hormone (LH) level"]
[null,"Mortality","Cowper's gland weight","Bone marrow histopathology","Estrus cyclicity","Learning and memory in offspring","[Not in list]","Steroidogenesis (genes/enzyme changes)"]
[null,"[Not in list]","Cowpers glands weight (Hershberger)","Brain histopathology examination","Fertility (mammals)","Litter/pup weight",null,"T3 and T4 level"]
[null,null,"Epididymis weight","Cervix histopathology","Gestation length","Motor activity",null,"Testosterone level"]
[null,null,"Epididymis weight (Hershberger)","Coagulating gland histopathology","Litter size","Motor and sensory function",null,"Thyroid-stimulating hormone level (TSH)"]
[null,null,"Glans penis weight","Colloid area (thyroid histopathology)","Litter viability","Pup development",null,"Thyroid-releasing hormone level (TRH)"]
[null,null,"Glans penis weight  (Hershberger)","Epididymis histopathology","Number of implantations, corpora lutea","[Not in list]",null,"Prolactin"]
[null,null,"Heart weight","Eyes histopathology","Number of live births",null,null,"Progesterone"]
[null,null,"Kidney weight","Follicular cell height (thyroid histopathology)","Number of ovarian follicles",null,null,"Cortisol"]
[null,null,"LABC weight","Gall bladder histopathology","Numbers of embryonic or foetal deaths and viable foetuses",null,null,"Androstenedione"]
[null,null,"LABC weight (Hershberger)","Heart histopathology","Post implantation loss",null,null,"Other hormones"]
[null,null,"Liver weight","Keratinisation and cornification of vagina","Pre implantation loss",null,null,"Nuclear receptor (in vivo)"]
[null,null,"Liver weight (Hershberger, considered T-mediated only in combination with other thyroid endpoints)","Keratinisation and cornification of vagina (UT assay)","Pup survival index",null,null,"CAR nuclear receptor (in vivo)"]
[null,null,"Liver weight (considered T-mediated only in combination with other thyroid endpoints)","Kidney histopathology","Reproduction",null,null,"PXR nuclear receptor (in vivo)"]
[null,null,"Ovary weight","Liver histopathology","Sex ratio",null,null,"PPAR nuclear receptor (in vivo)"]
[null,null,"Pituitary weight","Lung histopathology","Sperm morphology",null,null,"TSH receptor"]
[null,null,"Prostate weight","Lymph nodes histopathology","Sperm motility",null,null,"Phase I enzyme induction (in vivo)"]
[null,null,"Prostate weight (Hershberger)","Mammary gland histopathology (female)","Sperm numbers",null,null,"Phase II enzyme induction (in vivo)"]
[null,null,"Seminal vesicles weight","Mammary gland histopathology (male)","Time to mating",null,null,"Thyroid hormone clearance"]
[null,null,"Seminal vesicles weight (Hershberger)","Oesophagus histopathology","Vaginal opening (UT assay)",null,null,"Iodine uptake"]
[null,null,"Spleen weight","Ovary histopathology","[Not in list]",null,null,"Thyroperoxidase activity (TPO)"]
[null,null,"Testis weight","Oviduct histopathology",null,null,null,"Sodium-iodide symporter (NIS)"]
[null,null,"Testis weight (Hershberger)","Pancreas histopathology",null,null,null,"Thyroxin-binding protein (TBG)"]
[null,null,"Thymus weight","Peripheral nerve histopathology",null,null,null,"Transthyretin (TTR)"]
[null,null,"Thyroid weight","Pituitary histopathology",null,null,null,"Deiodination enzyme activity"]
[null,null,"Uterus weight (UT assay)","Proliferation of endometrial epithelium",null,null,null,"[Not in list]"]
[null,null,"Uterus weight (with cervix)","Proliferation of endometrial epithelium (UT assay)"]
[null,null,"[Not in list]","Prostate histopathology (with seminal vesicles and coagulating glands)"]
[null,null,null,"Salivary glands histopathology"]
[null,null,null,"Seminal vesicles histopathology"]
[null,null,null,"Skeletal muscle histopathology"]
[null,null,null,"Skin histopathology"]
[null,null,null,"Small and large intestines histopathology"]
[null,null,null,"Spinal cord histopathology"]
[null,null,null,"Spleen histopathology"]
[null,null,null,"Stomach histopathology"]
[null,null,null,"Testis histopathology"]
[null,null,null,"Thymus histopathology"]
[null,null,null,"Thyroid histopathology"]
[null,null,null,"Trachea histopathology"]
[null,null,null,"Urinary bladder histopathology"]
[null,null,null,"Uterus histopathology (UT assay)"]
[null,null,null,"Uterus histopathology (with cervix)"]
[null,null,null,"Vagina histopathology"]
[null,null,null,"Vaginal smears"]
[null,null,null,"[Not in list]"]

{"sheet":"LinkYZFish","index":4,"n_rows":13,"n_cols":7,"rows_kept":13,"cut":false,"hidden":true,"merged":[]}
["Column Y","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target"]
["Effect type","In life observation","Organ histopathology","Reproductive","Abnormalities","Clinical chemistry/hormones","No relevant effect observed"]
[null,"Behaviour (fish)","Kidney histopathology (fish)","Embryo time-to-hatch","Morphological abnormalities","Estradiol level","No relevant effect observed"]
[null,"Body weight (fish)","Liver histopathology (fish)","Gonado-somatic index",null,"Levels of thyroid hormones"]
[null,"Hepatosomatic index","Specific gonad histopathology","Hatching success",null,"Spiggin"]
[null,"Larval survival and length","[Not in list]","Male 2nd sex characteristics in females",null,"T3 and T4 level"]
[null,"Length (fish)",null,"Male 2nd sex characteristics in males",null,"Testosterone level"]
[null,"Mortality",null,"Reproduction (fecundity, fertility)",null,"Vitellogenin (VTG) in females"]
[null,"Survival (fish)",null,"Sex ratio (Female biased) ",null,"Vitellogenin (VTG) in males"]
[null,"Survival of embryos",null,"Sex ratio (Male biased) ",null,"[Not in list]"]
[null,"[Not in list]",null,"Time to maturity (time to first spawn)"]
[null,null,null,"Transcriptional activity of cyp19a1b"]
[null,null,null,"[Not in list]"]

{"sheet":"LinkYZAmphibian","index":5,"n_rows":7,"n_cols":9,"rows_kept":7,"cut":false,"hidden":true,"merged":[]}
["Column Y","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target"]
["Effect type","In life observation","Organ Weight","Organ histopathology","Reproductive","Developmental","Abnormalities","Clinical chemistry/hormones","No relevant effect observed"]
[null,"Behaviour (amphibian)","Liver weight (liver-somatic index;) (amphibian)","Histopathology (gonad, reproductive ducts)","Sex ratio (phenotypic [gonad histology], genetic)","Developmental stage","Malformations","Plasma level of vitellogenin","No relevant effect observed"]
[null,"Body weight (amphibian)","[Not in list]","Kidney histopathology (amphibian)",null,"Hind limb length","[Not in list]","Transcriptional activity of THbZIP"]
[null,"Mortality (amphibian)",null,"Liver histopathology (amphibian)",null,"Time to metamorphosis (NF stage 62)",null,"[Not in list]"]
[null,"Snout-vent length/growth",null,"Thyroid histopathology (amphibian)",null,"[Not in list]"]
[null,"[Not in list]",null,"[Not in list]"]

{"sheet":"LinkYZAvian","index":6,"n_rows":17,"n_cols":6,"rows_kept":17,"cut":false,"hidden":true,"merged":[]}
["Column Y","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target"]
["Effect type","In life observation","Organ histopathology","Reproductive","Clinical chemistry/hormones","No relevant effect observed"]
[null,"Body weight (bird)","Gonad histopathology (bird)","Cracked eggs","Estradiol, testosterone and thyroid hormone measurements (egg yolk, adult, thyroid hormone from thyroid gland)","No relevant effect observed"]
[null,"Mortality","Gross pathology (bird)","Egg fertility (embryonic day 8)","[Not in list]"]
[null,"[Not in list]","Kidney histopathology (bird)","Egg production"]
[null,null,"Liver histopathology (bird)","Egg viability (% viable embryo of egg set)"]
[null,null,"Thyroid gland histopathology (bird)","Eggshell strength (newton)"]
[null,null,"[Not in list]","Eggshell thickness"]
[null,null,null,"Embryo viability (embryonic day 15)"]
[null,null,null,"Hatchability"]
[null,null,null,"No of 14 day-old survivors"]
[null,null,null,"Phenotypic and genotypic sex ratio"]
[null,null,null,"Survival (bird)"]
[null,null,null,"Time to female reproductive maturation (first egg production)"]
[null,null,null,"Time to male reproductive maturation (first foam production)"]
[null,null,null,"Viable embryos"]
[null,null,null,"[Not in list]"]

{"sheet":"LinkInVitro","index":7,"n_rows":38,"n_cols":13,"rows_kept":38,"cut":false,"hidden":true,"merged":[]}
["Column Y","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target","Column Z Effect target"]
["Effect type","Receptor binding","Receptor (trans)activation","Receptor dimerization","Cofactor Recruitment","DNA Binding","Enzyme inhibition","Proliferation","Steroidogenesis","Transport protein binding","Enzyme inhibition/induction","Hormones measurments","[Not in list]"]
[null,"Estrogen receptor","Estrogen receptor","Estrogen receptor","Estrogen receptor","Estrogen receptor","Estrogen receptor","Estrogen receptor","Estrogen receptor","Estrogen receptor","Estrogen receptor","Estrogen receptor","No relevant effect observed"]
[null,"Estrogen related receptor","Estrogen related receptor","Estrogen related receptor","Estrogen related receptor","Estrogen related receptor","Estrogen related receptor","Estrogen related receptor","Estrogen related receptor","Estrogen related receptor","Estrogen related receptor","Estrogen related receptor"]
[null,"Androgen receptor","Androgen receptor","Androgen receptor","Androgen receptor","Androgen receptor","Androgen receptor","Androgen receptor","Androgen receptor","Androgen receptor","Androgen receptor","Androgen receptor"]
[null,"Thyroid receptor","Thyroid receptor","Thyroid receptor","Thyroid receptor","Thyroid receptor","Thyroid receptor","Thyroid receptor","Thyroid receptor","Thyroid receptor","Thyroid receptor","Thyroid receptor"]
[null,"Nuclear receptor (in vitro)","Nuclear receptor (in vitro)","Nuclear receptor (in vitro)","Nuclear receptor (in vitro)","Nuclear receptor (in vitro)","Nuclear receptor (in vitro)","Nuclear receptor (in vitro)","Nuclear receptor (in vitro)","Nuclear receptor (in vitro)","Nuclear receptor (in vitro)","Nuclear receptor (in vitro)"]
[null,"CAR nuclear receptor (in vitro)","CAR nuclear receptor (in vitro)","CAR nuclear receptor (in vitro)","CAR nuclear receptor (in vitro)","CAR nuclear receptor (in vitro)","CAR nuclear receptor (in vitro)","CAR nuclear receptor (in vitro)","CAR nuclear receptor (in vitro)","CAR nuclear receptor (in vitro)","CAR nuclear receptor (in vitro)","CAR nuclear receptor (in vitro)"]
[null,"PXR nuclear receptor (in vitro)","PXR nuclear receptor (in vitro)","PXR nuclear receptor (in vitro)","PXR nuclear receptor (in vitro)","PXR nuclear receptor (in vitro)","PXR nuclear receptor (in vitro)","PXR nuclear receptor (in vitro)","PXR nuclear receptor (in vitro)","PXR nuclear receptor (in vitro)","PXR nuclear receptor (in vitro)","PXR nuclear receptor (in vitro)"]
[null,"PPAR nuclear receptor (in vitro)","PPAR nuclear receptor (in vitro)","PPAR nuclear receptor (in vitro)","PPAR nuclear receptor (in vitro)","PPAR nuclear receptor (in vitro)","PPAR nuclear receptor (in vitro)","PPAR nuclear receptor (in vitro)","PPAR nuclear receptor (in vitro)","PPAR nuclear receptor (in vitro)","PPAR nuclear receptor (in vitro)","PPAR nuclear receptor (in vitro)"]
[null,"TSH receptor (in vitro)","TSH receptor (in vitro)","TSH receptor (in vitro)","TSH receptor (in vitro)","TSH receptor (in vitro)","TSH receptor (in vitro)","TSH receptor (in vitro)","TSH receptor (in vitro)","TSH receptor (in vitro)","TSH receptor (in vitro)","TSH receptor (in vitro)"]
[null,"Estradiol synthesis","Estradiol synthesis","Estradiol synthesis","Estradiol synthesis","Estradiol synthesis","Estradiol synthesis","Estradiol synthesis","Estradiol synthesis","Estradiol synthesis","Estradiol synthesis","Estradiol synthesis"]
[null,"Testosterone synthesis","Testosterone synthesis","Testosterone synthesis","Testosterone synthesis","Testosterone synthesis","Testosterone synthesis","Testosterone synthesis","Testosterone synthesis","Testosterone synthesis","Testosterone synthesis","Testosterone synthesis"]
[null,"CYP19","CYP19","CYP19","CYP19","CYP19","CYP19","CYP19","CYP19","CYP19","CYP19","CYP19"]
[null,"Steroidogenesis (genes/enzyme changes) (in vitro)","Steroidogenesis (genes/enzyme changes) (in vitro)","Steroidogenesis (genes/enzyme changes) (in vitro)","Steroidogenesis (genes/enzyme changes) (in vitro)","Steroidogenesis (genes/enzyme changes) (in vitro)","Steroidogenesis (genes/enzyme changes) (in vitro)","Steroidogenesis (genes/enzyme changes) (in vitro)","Steroidogenesis (genes/enzyme changes) (in vitro)","Steroidogenesis (genes/enzyme changes) (in vitro)","Steroidogenesis (genes/enzyme changes) (in vitro)","Steroidogenesis (genes/enzyme changes) (in vitro)"]
[null,"Estradiol level (in vitro)","Estradiol level (in vitro)","Estradiol level (in vitro)","Estradiol level (in vitro)","Estradiol level (in vitro)","Estradiol level (in vitro)","Estradiol level (in vitro)","Estradiol level (in vitro)","Estradiol level (in vitro)","Estradiol level (in vitro)","Estradiol level (in vitro)"]
[null,"Testosterone level (in vitro)","Testosterone level (in vitro)","Testosterone level (in vitro)","Testosterone level (in vitro)","Testosterone level (in vitro)","Testosterone level (in vitro)","Testosterone level (in vitro)","Testosterone level (in vitro)","Testosterone level (in vitro)","Testosterone level (in vitro)","Testosterone level (in vitro)"]
[null,"11-Deoxycortisol (in vitro)","11-Deoxycortisol (in vitro)","11-Deoxycortisol (in vitro)","11-Deoxycortisol (in vitro)","11-Deoxycortisol (in vitro)","11-Deoxycortisol (in vitro)","11-Deoxycortisol (in vitro)","11-Deoxycortisol (in vitro)","11-Deoxycortisol (in vitro)","11-Deoxycortisol (in vitro)","11-Deoxycortisol (in vitro)"]
[null,"17-alpha-hydroxypregnelone (in vitro)","17-alpha-hydroxypregnelone (in vitro)","17-alpha-hydroxypregnelone (in vitro)","17-alpha-hydroxypregnelone (in vitro)","17-alpha-hydroxypregnelone (in vitro)","17-alpha-hydroxypregnelone (in vitro)","17-alpha-hydroxypregnelone (in vitro)","17-alpha-hydroxypregnelone (in vitro)","17-alpha-hydroxypregnelone (in vitro)","17-alpha-hydroxypregnelone (in vitro)","17-alpha-hydroxypregnelone (in vitro)"]
[null,"17-alpha-hydroxyprogesterone (in vitro)","17-alpha-hydroxyprogesterone (in vitro)","17-alpha-hydroxyprogesterone (in vitro)","17-alpha-hydroxyprogesterone (in vitro)","17-alpha-hydroxyprogesterone (in vitro)","17-alpha-hydroxyprogesterone (in vitro)","17-alpha-hydroxyprogesterone (in vitro)","17-alpha-hydroxyprogesterone (in vitro)","17-alpha-hydroxyprogesterone (in vitro)","17-alpha-hydroxyprogesterone (in vitro)","17-alpha-hydroxyprogesterone (in vitro)"]
[null,"Androstenedione (in vitro)","Androstenedione (in vitro)","Androstenedione (in vitro)","Androstenedione (in vitro)","Androstenedione (in vitro)","Androstenedione (in vitro)","Androstenedione (in vitro)","Androstenedione (in vitro)","Androstenedione (in vitro)","Androstenedione (in vitro)","Androstenedione (in vitro)"]
[null,"Cortisol (in vitro)","Cortisol (in vitro)","Cortisol (in vitro)","Cortisol (in vitro)","Cortisol (in vitro)","Cortisol (in vitro)","Cortisol (in vitro)","Cortisol (in vitro)","Cortisol (in vitro)","Cortisol (in vitro)","Cortisol (in vitro)"]
[null,"11-Deoxycorticosterone (in vitro)","11-Deoxycorticosterone (in vitro)","11-Deoxycorticosterone (in vitro)","11-Deoxycorticosterone (in vitro)","11-Deoxycorticosterone (in vitro)","11-Deoxycorticosterone (in vitro)","11-Deoxycorticosterone (in vitro)","11-Deoxycorticosterone (in vitro)","11-Deoxycorticosterone (in vitro)","11-Deoxycorticosterone (in vitro)","11-Deoxycorticosterone (in vitro)"]
[null,"Estrone (in vitro)","Estrone (in vitro)","Estrone (in vitro)","Estrone (in vitro)","Estrone (in vitro)","Estrone (in vitro)","Estrone (in vitro)","Estrone (in vitro)","Estrone (in vitro)","Estrone (in vitro)","Estrone (in vitro)"]
[null,"Progesterone (in vitro)","Progesterone (in vitro)","Progesterone (in vitro)","Progesterone (in vitro)","Progesterone (in vitro)","Progesterone (in vitro)","Progesterone (in vitro)","Progesterone (in vitro)","Progesterone (in vitro)","Progesterone (in vitro)","Progesterone (in vitro)"]
[null,"T3 and T4 level (in vitro)","T3 and T4 level (in vitro)","T3 and T4 level (in vitro)","T3 and T4 level (in vitro)","T3 and T4 level (in vitro)","T3 and T4 level (in vitro)","T3 and T4 level (in vitro)","T3 and T4 level (in vitro)","T3 and T4 level (in vitro)","T3 and T4 level (in vitro)","T3 and T4 level (in vitro)"]
[null,"Thyroid-stimulating hormone level (TSH) (in vitro)","Thyroid-stimulating hormone level (TSH) (in vitro)","Thyroid-stimulating hormone level (TSH) (in vitro)","Thyroid-stimulating hormone level (TSH) (in vitro)","Thyroid-stimulating hormone level (TSH) (in vitro)","Thyroid-stimulating hormone level (TSH) (in vitro)","Thyroid-stimulating hormone level (TSH) (in vitro)","Thyroid-stimulating hormone level (TSH) (in vitro)","Thyroid-stimulating hormone level (TSH) (in vitro)","Thyroid-stimulating hormone level (TSH) (in vitro)","Thyroid-stimulating hormone level (TSH) (in vitro)"]
[null,"Other hormones (in vitro)","Other hormones (in vitro)","Other hormones (in vitro)","Other hormones (in vitro)","Other hormones (in vitro)","Other hormones (in vitro)","Other hormones (in vitro)","Other hormones (in vitro)","Other hormones (in vitro)","Other hormones (in vitro)","Other hormones (in vitro)"]
[null,"Phase I enzyme induction (in vitro)","Phase I enzyme induction (in vitro)","Phase I enzyme induction (in vitro)","Phase I enzyme induction (in vitro)","Phase I enzyme induction (in vitro)","Phase I enzyme induction (in vitro)","Phase I enzyme induction (in vitro)","Phase I enzyme induction (in vitro)","Phase I enzyme induction (in vitro)","Phase I enzyme induction (in vitro)","Phase I enzyme induction (in vitro)"]
[null,"Phase II enzyme induction (in vitro)","Phase II enzyme induction (in vitro)","Phase II enzyme induction (in vitro)","Phase II enzyme induction (in vitro)","Phase II enzyme induction (in vitro)","Phase II enzyme induction (in vitro)","Phase II enzyme induction (in vitro)","Phase II enzyme induction (in vitro)","Phase II enzyme induction (in vitro)","Phase II enzyme induction (in vitro)","Phase II enzyme induction (in vitro)"]
[null,"Thyroid hormone clearance (in vitro)","Thyroid hormone clearance (in vitro)","Thyroid hormone clearance (in vitro)","Thyroid hormone clearance (in vitro)","Thyroid hormone clearance (in vitro)","Thyroid hormone clearance (in vitro)","Thyroid hormone clearance (in vitro)","Thyroid hormone clearance (in vitro)","Thyroid hormone clearance (in vitro)","Thyroid hormone clearance (in vitro)","Thyroid hormone clearance (in vitro)"]
[null,"Thyroperoxidase activity (TPO) (in vitro)","Thyroperoxidase activity (TPO) (in vitro)","Thyroperoxidase activity (TPO) (in vitro)","Thyroperoxidase activity (TPO) (in vitro)","Thyroperoxidase activity (TPO) (in vitro)","Thyroperoxidase activity (TPO) (in vitro)","Thyroperoxidase activity (TPO) (in vitro)","Thyroperoxidase activity (TPO) (in vitro)","Thyroperoxidase activity (TPO) (in vitro)","Thyroperoxidase activity (TPO) (in vitro)","Thyroperoxidase activity (TPO) (in vitro)"]
[null,"Sodium-iodide symporter (NIS) (in vitro)","Sodium-iodide symporter (NIS) (in vitro)","Sodium-iodide symporter (NIS) (in vitro)","Sodium-iodide symporter (NIS) (in vitro)","Sodium-iodide symporter (NIS) (in vitro)","Sodium-iodide symporter (NIS) (in vitro)","Sodium-iodide symporter (NIS) (in vitro)","Sodium-iodide symporter (NIS) (in vitro)","Sodium-iodide symporter (NIS) (in vitro)","Sodium-iodide symporter (NIS) (in vitro)","Sodium-iodide symporter (NIS) (in vitro)"]
[null,"Thyroxin-binding protein (TBG) (in vitro)","Thyroxin-binding protein (TBG) (in vitro)","Thyroxin-binding protein (TBG) (in vitro)","Thyroxin-binding protein (TBG) (in vitro)","Thyroxin-binding protein (TBG) (in vitro)","Thyroxin-binding protein (TBG) (in vitro)","Thyroxin-binding protein (TBG) (in vitro)","Thyroxin-binding protein (TBG) (in vitro)","Thyroxin-binding protein (TBG) (in vitro)","Thyroxin-binding protein (TBG) (in vitro)","Thyroxin-binding protein (TBG) (in vitro)"]
[null,"Transthyretin (TTR) (in vitro)","Transthyretin (TTR) (in vitro)","Transthyretin (TTR) (in vitro)","Transthyretin (TTR) (in vitro)","Transthyretin (TTR) (in vitro)","Transthyretin (TTR) (in vitro)","Transthyretin (TTR) (in vitro)","Transthyretin (TTR) (in vitro)","Transthyretin (TTR) (in vitro)","Transthyretin (TTR) (in vitro)","Transthyretin (TTR) (in vitro)"]
[null,"Deiodination enzyme activity (in vitro)","Deiodination enzyme activity (in vitro)","Deiodination enzyme activity (in vitro)","Deiodination enzyme activity (in vitro)","Deiodination enzyme activity (in vitro)","Deiodination enzyme activity (in vitro)","Deiodination enzyme activity (in vitro)","Deiodination enzyme activity (in vitro)","Deiodination enzyme activity (in vitro)","Deiodination enzyme activity (in vitro)","Deiodination enzyme activity (in vitro)"]
[null,"Cellular proliferation","Cellular proliferation","Cellular proliferation","Cellular proliferation","Cellular proliferation","Cellular proliferation","Cellular proliferation","Cellular proliferation","Cellular proliferation","Cellular proliferation","Cellular proliferation"]
[null,"[Not in list]","[Not in list]","[Not in list]","[Not in list]","[Not in list]","[Not in list]","[Not in list]","[Not in list]","[Not in list]","[Not in list]","[Not in list]"]

{"sheet":"Interpretation","index":8,"n_rows":251,"n_cols":5,"rows_kept":251,"cut":false,"hidden":true,"merged":[]}
["Column A","Column Y","Column Z","Column AA","Indicative of"]
["Mammals","Abnormalities","Ano-Genital distance","EATS-mediated","E, A, S"]
["Mammals","Abnormalities","Genital abnormalities","EATS-mediated","E, A, S"]
["Mammals","Abnormalities","Nipple Development","EATS-mediated","A"]
["Mammals","Abnormalities","Presence of anomalies (external, visceral, skeletal","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Clinical chemistry","Estradiol level","In vivo mechanistic","E, A, S"]
["Mammals","Clinical chemistry","Follicle Stimulating Hormone (FSH) level","In vivo mechanistic","E, A, S"]
["Mammals","Clinical chemistry","Luteinizing Hormone (LH) level","In vivo mechanistic","E, A, S"]
["Mammals","Clinical chemistry","Steroidogenesis (genes/enzyme changes)","In vivo mechanistic","E, A, S"]
["Mammals","Clinical chemistry","T3 and T4 level","In vivo mechanistic","T"]
["Mammals","Clinical chemistry","Testosterone level","In vivo mechanistic","E, A, S"]
["Mammals","Clinical chemistry","Thyroid-stimulating hormone level (TSH)","In vivo mechanistic","T"]
["Mammals","Clinical chemistry","Thyroid-releasing hormone level (TRH)","In vivo mechanistic","T"]
["Mammals","Clinical chemistry","Prolactin","In vivo mechanistic","E, A, T, S"]
["Mammals","Clinical chemistry","Progesterone","In vivo mechanistic","E, A, S"]
["Mammals","Clinical chemistry","Cortisol","In vivo mechanistic","E, A, S"]
["Mammals","Clinical chemistry","Androstenedione","In vivo mechanistic","E, A, S"]
["Mammals","Clinical chemistry","Other hormones","In vivo mechanistic","_"]
["Mammals","Clinical chemistry","Nuclear receptor (in vivo)","In vivo mechanistic","E, A, T, S"]
["Mammals","Clinical chemistry","CAR nuclear receptor (in vivo)","In vivo mechanistic","E, A, T, S"]
["Mammals","Clinical chemistry","PXR nuclear receptor (in vivo)","In vivo mechanistic","E, A, T, S"]
["Mammals","Clinical chemistry","PPAR nuclear receptor (in vivo)","In vivo mechanistic","E, A, T, S"]
["Mammals","Clinical chemistry","TSH receptor","In vivo mechanistic","T"]
["Mammals","Clinical chemistry","Phase I enzyme induction (in vivo)","In vivo mechanistic","E, A, T, S"]
["Mammals","Clinical chemistry","Phase II enzyme induction (in vivo)","In vivo mechanistic","E, A, T, S"]
["Mammals","Clinical chemistry","Thyroid hormone clearance","In vivo mechanistic","T"]
["Mammals","Clinical chemistry","Iodine uptake","In vivo mechanistic","T"]
["Mammals","Clinical chemistry","Thyroperoxidase activity (TPO)","In vivo mechanistic","T"]
["Mammals","Clinical chemistry","Sodium-iodide symporter (NIS)","In vivo mechanistic","T"]
["Mammals","Clinical chemistry","Thyroxin-binding protein (TBG)","In vivo mechanistic","T"]
["Mammals","Clinical chemistry","Transthyretin (TTR)","In vivo mechanistic","T"]
["Mammals","Clinical chemistry","Deiodination enzyme activity","In vivo mechanistic","T"]
["Mammals","Clinical chemistry","HDL/LDL ratio (considered T-mediated only in combination with other thyroid endpoints)","EATS-mediated","T"]
["Mammals","Developmental","Auditory startle","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Developmental","Brain morphometric (quantitative) evaluation","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Developmental","Fetal development","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Developmental","Functional observation battery","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Developmental","Learning and memory in offspring","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Developmental","Litter/pup weight","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Developmental","Motor activity","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Developmental","Motor and sensory function","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Developmental","Pup development","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Organ histopathology","Keratinisation and cornification of vagina (UT assay)","In vivo mechanistic","E"]
["Mammals","Organ histopathology","Proliferation of endometrial epithelium (UT assay)","In vivo mechanistic","E"]
["Mammals","Organ histopathology","Uterus histopathology (UT assay)","In vivo mechanistic","E"]
["Mammals","Organ histopathology","Accessory sex organs histopathology","EATS-mediated","E, A, S"]
["Mammals","Organ histopathology","Cervix histopathology","EATS-mediated","E, A, S"]
["Mammals","Organ histopathology","Coagulating gland histopathology","EATS-mediated","E, A, S"]
["Mammals","Organ histopathology","Colloid area (thyroid histopathology)","EATS-mediated","T"]
["Mammals","Organ histopathology","Epididymis histopathology","EATS-mediated","E, A, S"]
["Mammals","Organ histopathology","Follicular cell height (thyroid histopathology)","EATS-mediated","T"]
["Mammals","Organ histopathology","Mammary gland histopathology (male)","EATS-mediated","E, A, S"]
["Mammals","Organ histopathology","Mammary gland histopathology (female)","EATS-mediated","E, A, S"]
["Mammals","Organ histopathology","Ovary histopathology","EATS-mediated","E, A, S"]
["Mammals","Organ histopathology","Oviduct histopathology","EATS-mediated","E, A, S"]
["Mammals","Organ histopathology","Keratinisation and cornification of vagina","EATS-mediated","E"]
["Mammals","Organ histopathology","Proliferation of endometrial epithelium","EATS-mediated","E"]
["Mammals","Organ histopathology","Prostate histopathology (with seminal vesicles and coagulating glands)","EATS-mediated","E, A, S"]
["Mammals","Organ histopathology","Seminal vesicles histopathology","EATS-mediated","E, A, S"]
["Mammals","Organ histopathology","Testis histopathology","EATS-mediated","E, A, S"]
["Mammals","Organ histopathology","Thyroid histopathology","EATS-mediated","T"]
["Mammals","Organ histopathology","Uterus histopathology (with cervix)","EATS-mediated","E, A, S"]
["Mammals","Organ histopathology","Vagina histopathology","EATS-mediated","E, A, S"]
["Mammals","Organ histopathology","Vaginal smears","EATS-mediated","E, A, S"]
["Mammals","Organ histopathology","Adrenals histopathology","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Organ histopathology","Brain histopathology examination","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Organ histopathology","Pituitary histopathology","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Organ histopathology","Aorta histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Bone histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Bone marrow histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Eyes histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Gall bladder histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Heart histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Kidney histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Liver histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Lung histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Lymph nodes histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Oesophagus histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Pancreas histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Peripheral nerve histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Salivary glands histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Skeletal muscle histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Skin histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Small and large intestines histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Spinal cord histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Spleen histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Stomach histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Thymus histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Trachea histopathology","Target organ toxicity","_"]
["Mammals","Organ histopathology","Urinary bladder histopathology","Target organ toxicity","_"]
["Mammals","Organ Weight","Adrenals weight (Hershberger)","In vivo mechanistic","N"]
["Mammals","Organ Weight","Cowpers glands weight (Hershberger)","In vivo mechanistic","A"]
["Mammals","Organ Weight","Epididymis weight (Hershberger)","In vivo mechanistic","E, A, S"]
["Mammals","Organ Weight","Glans penis weight  (Hershberger)","In vivo mechanistic","A"]
["Mammals","Organ Weight","LABC weight (Hershberger)","In vivo mechanistic","A"]
["Mammals","Organ Weight","Liver weight (Hershberger, considered T-mediated only in combination with other thyroid endpoints)","In vivo mechanistic","T"]
["Mammals","Organ Weight","Prostate weight (Hershberger)","In vivo mechanistic","A"]
["Mammals","Organ Weight","Seminal vesicles weight (Hershberger)","In vivo mechanistic","A"]
["Mammals","Organ Weight","Testis weight (Hershberger)","In vivo mechanistic","E, A, S"]
["Mammals","Organ Weight","Uterus weight (UT assay)","In vivo mechanistic","E, A"]
["Mammals","Organ Weight","Coagulating gland weight","EATS-mediated","E, A, S"]
["Mammals","Organ Weight","Cowper's gland weight","EATS-mediated","E, A, S"]
["Mammals","Organ Weight","Epididymis weight","EATS-mediated","E, A, S"]
["Mammals","Organ Weight","Glans penis weight","EATS-mediated","E, A, S"]
["Mammals","Organ Weight","LABC weight","EATS-mediated","E, A, S"]
["Mammals","Organ Weight","Liver weight (considered T-mediated only in combination with other thyroid endpoints)","EATS-mediated","T"]
["Mammals","Organ Weight","Ovary weight","EATS-mediated","E, A, S"]
["Mammals","Organ Weight","Prostate weight","EATS-mediated","E, A, S"]
["Mammals","Organ Weight","Seminal vesicles weight","EATS-mediated","E, A, S"]
["Mammals","Organ Weight","Testis weight","EATS-mediated","E, A, S"]
["Mammals","Organ Weight","Thyroid weight","EATS-mediated","T"]
["Mammals","Organ Weight","Uterus weight (with cervix)","EATS-mediated","E, A, S"]
["Mammals","Organ Weight","Adrenals weight","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Organ Weight","Brain weight","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Organ Weight","Pituitary weight","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Organ Weight","Heart weight","Target organ toxicity","_"]
["Mammals","Organ Weight","Kidney weight","Target organ toxicity","_"]
["Mammals","Organ Weight","Liver weight","Target organ toxicity","_"]
["Mammals","Organ Weight","Spleen weight","Target organ toxicity","_"]
["Mammals","Organ Weight","Thymus weight","Target organ toxicity","_"]
["Mammals","Reproductive","Vaginal opening (UT assay)","In vivo mechanistic","E, A"]
["Mammals","Reproductive","Age at first estrus","EATS-mediated","E, A"]
["Mammals","Reproductive","Age at balanopreputial separation","EATS-mediated","E, A, S"]
["Mammals","Reproductive","Age at vaginal opening","EATS-mediated","E, A, S"]
["Mammals","Reproductive","Estrus cyclicity","EATS-mediated","E, A, S"]
["Mammals","Reproductive","Sperm morphology","EATS-mediated","E, A, S"]
["Mammals","Reproductive","Sperm motility","EATS-mediated","E, A, S"]
["Mammals","Reproductive","Sperm numbers","EATS-mediated","E, A, S"]
["Mammals","Reproductive","Dystocia","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Reproductive","Fertility (mammals)","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Reproductive","Gestation length","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Reproductive","Litter size","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Reproductive","Litter viability","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Reproductive","Number of implantations, corpora lutea","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Reproductive","Number of live births","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Reproductive","Numbers of embryonic or foetal deaths and viable foetuses","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Reproductive","Number of ovarian follicles","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Reproductive","Post implantation loss","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Reproductive","Pre implantation loss","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Reproductive","Pup survival index","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Reproductive","Reproduction","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Reproductive","Sex ratio","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","Reproductive","Time to mating","Sensitive to, but not diagnostic of, EATS","N"]
["Mammals","In life observation","Body weight","Systemic toxicity","_"]
["Mammals","In life observation","Clinical chemistry and haematology","Systemic toxicity","_"]
["Mammals","In life observation","Clinical signs","Systemic toxicity","_"]
["Mammals","In life observation","Food consumption","Systemic toxicity","_"]
["Mammals","In life observation","Mortality","Systemic toxicity","_"]
["Fish","Abnormalities","Morphological abnormalities","Sensitive to, but not diagnostic of, EATS","N"]
["Fish","Clinical chemistry","Vitellogenin (VTG) in females","In vivo mechanistic","E, A, S"]
["Fish","Clinical chemistry","Vitellogenin (VTG) in males","In vivo mechanistic","E, A, S"]
["Fish","Clinical chemistry","Spiggin","In vivo mechanistic","A"]
["Fish","Clinical chemistry","Estradiol level","In vivo mechanistic"]
["Fish","Clinical chemistry","Levels of thyroid hormones","In vivo mechanistic"]
["Fish","Clinical chemistry","T3 and T4 level","In vivo mechanistic"]
["Fish","Clinical chemistry","Testosterone level","In vivo mechanistic"]
["Fish","Clinical chemistry","Transcriptional activity of cyp19a1b","In vivo mechanistic","E"]
["Fish","Developmental","Behaviour (fish)","Sensitive to, but not diagnostic of, EATS","N"]
["Fish","Developmental","Length (fish)","Sensitive to, but not diagnostic of, EATS","N"]
["Fish","Organ histopathology","Specific gonad histopathology","EATS-mediated","E, A, S"]
["Fish","In life observation","Liver histopathology (fish)","Systemic toxicity","_"]
["Fish","In life observation","Kidney histopathology (fish)","Systemic toxicity","_"]
["Fish","In life observation","Body weight (fish)","Sensitive to, but not diagnostic of, EATS","N"]
["Fish","Reproductive","Male 2nd sex characteristics in females","EATS-mediated","A"]
["Fish","Reproductive","Male 2nd sex characteristics in males","EATS-mediated","E, A, S"]
["Fish","Reproductive","Sex ratio (Female biased) ","EATS-mediated","E, A"]
["Fish","Reproductive","Sex ratio (Male biased) ","EATS-mediated","E, A, S"]
["Fish","Reproductive","Gonado-somatic index","Sensitive to, but not diagnostic of, EATS","N"]
["Fish","Reproductive","Embryo time-to-hatch","Sensitive to, but not diagnostic of, EATS","N"]
["Fish","Reproductive","Reproduction (fecundity, fertility)","Sensitive to, but not diagnostic of, EATS","N"]
["Fish","In life observation","Survival (fish)","Systemic toxicity","_"]
["Fish","Reproductive","Larval survival and length","Sensitive to, but not diagnostic of, EATS","N"]
["Fish","Reproductive","Survival of embryos","Sensitive to, but not diagnostic of, EATS","N"]
["Fish","Reproductive","Time to maturity (time to first spawn)","Sensitive to, but not diagnostic of, EATS","N"]
["Fish","Reproductive","Hatching success","Sensitive to, but not diagnostic of, EATS","N"]
["Fish","In life observation","Hepatosomatic index","Systemic toxicity","_"]
["Fish","In life observation","Mortality","Systemic toxicity","_"]
["Amphibians","Abnormalities","Malformations","Sensitive to, but not diagnostic of, EATS","N"]
["Amphibians","Clinical chemistry","Plasma level of vitellogenin","In vivo mechanistic","E, A, S"]
["Amphibians","Clinical chemistry","Transcriptional activity of THbZIP","In vivo mechanistic","T"]
["Amphibians","Developmental","Hind limb length","EATS-mediated","T"]
["Amphibians","Developmental","Developmental stage","EATS-mediated","T"]
["Amphibians","Developmental","Time to metamorphosis (NF stage 62)","EATS-mediated","T"]
["Amphibians","Developmental","Snout-vent length/growth","Sensitive to, but not diagnostic of, EATS","N"]
["Amphibians","Developmental","Behaviour (amphibian)","Sensitive to, but not diagnostic of, EATS","N"]
["Amphibians","In life observation","Mortality (amphibian)","Systemic toxicity","_"]
["Amphibians","Organ histopathology","Thyroid histopathology (amphibian)","EATS-mediated","T"]
["Amphibians","Organ histopathology","Histopathology (gonad, reproductive ducts)","EATS-mediated","E, A"]
["Amphibians","In life observation","Liver histopathology (amphibian)","Systemic toxicity","_"]
["Amphibians","In life observation","Kidney histopathology (amphibian)","Systemic toxicity","_"]
["Amphibians","In life observation","Body weight (amphibian)","Sensitive to, but not diagnostic of, EATS","N"]
["Amphibians","Organ Weight","Liver weight (liver-somatic index;) (amphibian)","Sensitive to, but not diagnostic of, EATS","N"]
["Birds","Clinical chemistry","Estradiol, testosterone and thyroid hormone measurements (egg yolk, adult, thyroid hormone from thyroid gland)","In vivo mechanistic","E, A, T, S"]
["Birds","Organ histopathology","Thyroid gland histopathology (bird)","EATS-mediated","T"]
["Birds","Organ histopathology","Gonad histopathology (bird)","EATS-mediated","E, A"]
["Birds","Organ histopathology","Gross pathology (bird)","Sensitive to, but not diagnostic of, EATS","N"]
["Birds","In life observation","Liver histopathology (bird)","Systemic toxicity","_"]
["Birds","In life observation","Kidney histopathology (bird)","Systemic toxicity","_"]
["Birds","In life observation","Body weight (bird)","Sensitive to, but not diagnostic of, EATS","N"]
["Birds","Reproductive","Phenotypic and genotypic sex ratio","EATS-mediated","E, A"]
["Birds","Reproductive","Hatchability","Sensitive to, but not diagnostic of, EATS","N"]
["Birds","Reproductive","Egg fertility (embryonic day 8)","Sensitive to, but not diagnostic of, EATS","N"]
["Birds","Reproductive","Eggshell thickness","Sensitive to, but not diagnostic of, EATS","N"]
["Birds","Reproductive","Eggshell strength (newton)","Sensitive to, but not diagnostic of, EATS","N"]
["Birds","Reproductive","Egg viability (% viable embryo of egg set)","Sensitive to, but not diagnostic of, EATS","N"]
["Birds","Reproductive","Embryo viability (embryonic day 15)","Sensitive to, but not diagnostic of, EATS","N"]
["Birds","Reproductive","Egg production","Sensitive to, but not diagnostic of, EATS","N"]
["Birds","Reproductive","Cracked eggs","Sensitive to, but not diagnostic of, EATS","N"]
["Birds","In life observation","Survival (bird)","Systemic toxicity","_"]
["Birds","Reproductive","Viable embryos","Sensitive to, but not diagnostic of, EATS","N"]
["Birds","Reproductive","No of 14 day-old survivors","Sensitive to, but not diagnostic of, EATS","N"]
["Birds","Reproductive","Time to female reproductive maturation (first egg production)","Sensitive to, but not diagnostic of, EATS","N"]
["Birds","Reproductive","Time to male reproductive maturation (first foam production)","Sensitive to, but not diagnostic of, EATS","N"]
["Birds","In life observation","Mortality","Systemic toxicity","_"]
["In vitro",null,"Estrogen receptor","In vitro mechanistic","E"]
["In vitro",null,"Estrogen related receptor","In vitro mechanistic","E"]
["In vitro",null,"Androgen receptor","In vitro mechanistic","A"]
["In vitro",null,"Thyroid receptor","In vitro mechanistic","T"]
["In vitro",null,"Nuclear receptor (in vitro)","In vitro mechanistic","E, A, T, S"]
["In vitro",null,"CAR nuclear receptor (in vitro)","In vitro mechanistic","E, A, T, S"]
["In vitro",null,"PXR nuclear receptor (in vitro)","In vitro mechanistic","E, A, T, S"]
["In vitro",null,"PPAR nuclear receptor (in vitro)","In vitro mechanistic","E, A, T, S"]
["In vitro",null,"TSH receptor (in vitro)","In vitro mechanistic","T"]
["In vitro",null,"Estradiol synthesis","In vitro mechanistic","E, A, S"]
["In vitro",null,"Testosterone synthesis","In vitro mechanistic","E, A, S"]
["In vitro",null,"CYP19","In vitro mechanistic","S"]
["In vitro",null,"Steroidogenesis (genes/enzyme changes) (in vitro)","In vitro mechanistic","S"]
["In vitro",null,"Estradiol level (in vitro)","In vitro mechanistic","E"]
["In vitro",null,"Testosterone level (in vitro)","In vitro mechanistic","A"]
["In vitro",null,"T3 and T4 level (in vitro)","In vitro mechanistic","T"]
["In vitro",null,"Thyroid-stimulating hormone level (TSH) (in vitro)","In vitro mechanistic","T"]
["In vitro",null,"Other hormones (in vitro)","In vitro mechanistic","_"]
["In vitro",null,"Phase I enzyme induction (in vitro)","In vitro mechanistic","E, A, T, S"]
["In vitro",null,"Phase II enzyme induction (in vitro)","In vitro mechanistic","E, A, T, S"]
["In vitro",null,"Thyroid hormone clearance (in vitro)","In vitro mechanistic","T"]
["In vitro",null,"Thyroperoxidase activity (TPO) (in vitro)","In vitro mechanistic","T"]
["In vitro",null,"Sodium-iodide symporter (NIS) (in vitro)","In vitro mechanistic","T"]
["In vitro",null,"Thyroxin-binding protein (TBG) (in vitro)","In vitro mechanistic","T"]
["In vitro",null,"Transthyretin (TTR) (in vitro)","In vitro mechanistic","T"]
["In vitro",null,"Deiodination enzyme activity (in vitro)","In vitro mechanistic","T"]
["In vitro",null,"Cellular proliferation","In vitro mechanistic","E, A, T, S"]
["In vitro",null,"11-Deoxycortisol (in vitro)","In vitro mechanistic","E, A, S"]
["In vitro",null,"17-alpha-hydroxypregnelone (in vitro)","In vitro mechanistic","E, A, S"]
["In vitro",null,"17-alpha-hydroxyprogesterone (in vitro)","In vitro mechanistic","E, A, S"]
["In vitro",null,"Androstenedione (in vitro)","In vitro mechanistic","E, A, S"]
["In vitro",null,"Cortisol (in vitro)","In vitro mechanistic","E, A, S"]
["In vitro",null,"11-Deoxycorticosterone (in vitro)","In vitro mechanistic","E, A, S"]
["In vitro",null,"Estrone (in vitro)","In vitro mechanistic","E, A, S"]
["In vitro",null,"Progesterone (in vitro)","In vitro mechanistic","E, A, S"]
[null,null,"[Not in list]","[Not in list]"]
[null,null,"No relevant effect observed","No relevant effect observed"]

{"sheet":"Data_RMS","index":9,"n_rows":93,"n_cols":37,"rows_kept":93,"cut":false,"hidden":false,"merged":[]}
["Compound:","Glyphosate"]
["CAS:","1071-83-6 "]
["Comments:",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"E = Endpoints for estrogen-mediated activity"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"A = Endpoints for androgen-mediated activity"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"T = Endpoints for thyroid-related activity"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"S = Endpoints for steroidogenesisrelated activity"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"N = Endpoints potentially sensitive to, but not diagnostic of, EATS modalities"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"_ = Endpoints related to target organ toxicity and systemic toxicity"]
[]
[]
["Type of toxicity","Study principle","Study ID Matrix","Study reference ID"," Study guideline (OECD/US EPA) or remarks","Source","Reference (citation)","Reporting date","Species","Strain or in vitro model","Animals/sex/group","Sex (administration)","Purity (%)","Route of administration","Method of administration","Doses tested","Lowest dose tested","Highest dose tested","Dose unit","Duration of exposure","Duration unit","Generation/Life stage","Sex (effect dose)","Lowest Effect dose","Effect type","Effect target","Effect classification","Effect description","Effect determination","Effect direction","NOAEL/NOEL/NOEC","LOAEL/LOEL/LOEC","Unit","Effect indicative of","Additional remarks","Relevance","Reliability"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(Z12<>0,VLOOKUP(Z12,Interpretation!$C:$E,2,FALSE),\"\")","v":""},null,null,null,null,null,null,{"$f":"IF(Z12<>0,VLOOKUP(Z12,Interpretation!$C:$E,3,FALSE),\"\")","v":""}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(Z13<>0,VLOOKUP(Z13,Interpretation!$C:$E,2,FALSE),\"\")","v":""},null,null,null,null,null,null,{"$f":"IF(Z13<>0,VLOOKUP(Z13,Interpretation!$C:$E,3,FALSE),\"\")","v":""}]
["Avian","Avian reproduction test","1a","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Adult","M + F","> 2250","In life observation","Mortality",{"$f":"IF(Z14<>0,VLOOKUP(Z14,Interpretation!$C:$E,2,FALSE),\"\")","v":"Systemic toxicity"},"Mortality","Relative","No effect",2250,"> 2250","ppm",{"$f":"IF(Z14<>0,VLOOKUP(Z14,Interpretation!$C:$E,3,FALSE),\"\")","v":"_"},"After Week 19: \"hysteria attack\", 6 mortalities in control, 2 mortalities in each treatment","No","No"]
["Avian","Avian reproduction test","1b","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Adult","M + F","> 2250","In life observation","Body weight (bird)",{"$f":"IF(Z15<>0,VLOOKUP(Z15,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Body weight","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z15<>0,VLOOKUP(Z15,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"In Week 8: statistical increase in male bw at 500","No","No"]
["Avian","Avian reproduction test","1c","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Adult","M + F","> 2250","In life observation","[Not in list]","Sensitive to, but not diagnostic of, EATS","Clinical observations, behaviour","Absolute","No effect",2250,"> 2250","ppm","N",null,"No","No"]
["Avian","Avian reproduction test","1d","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Adult","M + F","> 2250","In life observation","[Not in list]","Sensitive to, but not diagnostic of, EATS","Feed consumption","Absolute","No effect",2250,"> 2250","ppm","N",null,"No","No"]
["Avian","Avian reproduction test","1e","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Adult","M + F","> 2250","Organ histopathology","Gross pathology (bird)",{"$f":"IF(Z18<>0,VLOOKUP(Z18,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Gross necropsy of survivors","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z18<>0,VLOOKUP(Z18,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"No","No"]
["Avian","Avian reproduction test","1f","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Adult","F","> 2250","Reproductive","Egg production",{"$f":"IF(Z19<>0,VLOOKUP(Z19,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Eggs/female divided by maximum laid","Relative","No effect",2250,"> 2250","ppm",{"$f":"IF(Z19<>0,VLOOKUP(Z19,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"No","No"]
["Avian","Avian reproduction test","1g","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Adult","F","> 2250","Reproductive","Cracked eggs",{"$f":"IF(Z20<>0,VLOOKUP(Z20,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Cracked eggs","Relative","No effect",2250,"> 2250","ppm",{"$f":"IF(Z20<>0,VLOOKUP(Z20,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"No","No"]
["Avian","Avian reproduction test","1h","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Adult","F","> 2250","Reproductive","Egg viability (% viable embryo of egg set)",{"$f":"IF(Z21<>0,VLOOKUP(Z21,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Candled at Day 11 or 12","Relative","No effect",2250,"> 2250","ppm",{"$f":"IF(Z21<>0,VLOOKUP(Z21,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"No","No"]
["Avian","Avian reproduction test","1i","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Adult","F","> 2250","Reproductive","Eggshell thickness",{"$f":"IF(Z22<>0,VLOOKUP(Z22,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Eggshell thickness","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z22<>0,VLOOKUP(Z22,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"No","No"]
["Avian","Avian reproduction test","1j","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Offspring (F1)","F","> 2250","Reproductive","Viable embryos",{"$f":"IF(Z23<>0,VLOOKUP(Z23,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Live embryos at Day 21","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z23<>0,VLOOKUP(Z23,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"No","No"]
["Avian","Avian reproduction test","1k","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Offspring (F1)","F","> 2250","Reproductive","Hatchability",{"$f":"IF(Z24<>0,VLOOKUP(Z24,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"of live 3-week embryos; of eggs set; of maximum set","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z24<>0,VLOOKUP(Z24,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"No","No"]
["Avian","Avian reproduction test","1l","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Offspring (F1)","M + F","> 2250","In life observation","No of 14 day-old survivors",{"$f":"IF(Z25<>0,VLOOKUP(Z25,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"of hatchlings; of eggs set; of maximum set","Relative","No effect",2250,"> 2250","ppm",{"$f":"IF(Z25<>0,VLOOKUP(Z25,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"No","No"]
["Avian","Avian reproduction test","1m","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Offspring (F1)","M + F","> 2250","In life observation","Body weight (bird)",{"$f":"IF(Z26<>0,VLOOKUP(Z26,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"14-day old survivors","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z26<>0,VLOOKUP(Z26,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"No","No"]
["Avian","Avian reproduction test","2a","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","M + F","> 2250","In life observation","Mortality",{"$f":"IF(Z27<>0,VLOOKUP(Z27,Interpretation!$C:$E,2,FALSE),\"\")","v":"Systemic toxicity"},"Mortality","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z27<>0,VLOOKUP(Z27,Interpretation!$C:$E,3,FALSE),\"\")","v":"_"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2b","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","M + F","> 2250","In life observation","Body weight (bird)",{"$f":"IF(Z28<>0,VLOOKUP(Z28,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Body weight","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z28<>0,VLOOKUP(Z28,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2c","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","M + F","> 2250","In life observation","[Not in list]","Sensitive to, but not diagnostic of, EATS","Clinical observations, behaviour","Absolute","No effect",2250,"> 2250","ppm","N",null,"Yes","Yes"]
["Avian","Avian reproduction test","2d","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","M + F","> 2250","In life observation","[Not in list]","Sensitive to, but not diagnostic of, EATS","Feed consumption","Absolute","No effect",2250,"> 2250","ppm","N",null,"Yes","Yes"]
["Avian","Avian reproduction test","2e","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","M + F","> 2250","Organ histopathology","Gross pathology (bird)",{"$f":"IF(Z31<>0,VLOOKUP(Z31,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Gross necropsy of survivors","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z31<>0,VLOOKUP(Z31,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2f","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","F","> 2250","Reproductive","Egg production",{"$f":"IF(Z32<>0,VLOOKUP(Z32,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Eggs/female divided by maximum laid","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z32<>0,VLOOKUP(Z32,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2g","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","F","> 2250","Reproductive","Cracked eggs",{"$f":"IF(Z33<>0,VLOOKUP(Z33,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Cracked eggs","Relative","No effect",2250,"> 2250","ppm",{"$f":"IF(Z33<>0,VLOOKUP(Z33,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2h","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","F","> 2250","Reproductive","Egg viability (% viable embryo of egg set)",{"$f":"IF(Z34<>0,VLOOKUP(Z34,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Candled at Day 11 or 12","Relative","No effect",2250,"> 2250","ppm",{"$f":"IF(Z34<>0,VLOOKUP(Z34,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2i","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","F","> 2250","Reproductive","Eggshell thickness",{"$f":"IF(Z35<>0,VLOOKUP(Z35,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Eggshell thickness","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z35<>0,VLOOKUP(Z35,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2j","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","F","> 2250","Reproductive","Viable embryos",{"$f":"IF(Z36<>0,VLOOKUP(Z36,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Live embryos at Day 21","Relative","No effect",2250,"> 2250","ppm",{"$f":"IF(Z36<>0,VLOOKUP(Z36,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2k","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","F","> 2250","Reproductive","Hatchability",{"$f":"IF(Z37<>0,VLOOKUP(Z37,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"of live 3-week embryos; of eggs set; of maximum set","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z37<>0,VLOOKUP(Z37,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2l","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Offspring (F1)","M + F","> 2250","Reproductive","No of 14 day-old survivors",{"$f":"IF(Z38<>0,VLOOKUP(Z38,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Number of 14-day-old survivors ","Relative","No effect",2250,"> 2250","ppm",{"$f":"IF(Z38<>0,VLOOKUP(Z38,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2m","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Offspring (F1)","M + F",2250,"In life observation","Body weight (bird)",{"$f":"IF(Z39<>0,VLOOKUP(Z39,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Body weight of 14 -day old survivors","Absolute","Decrease",1000,2250,"ppm",{"$f":"IF(Z39<>0,VLOOKUP(Z39,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"Significant decrease at 2250 ppm but at level of control of a different, parallel mallard study","Yes","Yes"]
["Avian","Avian reproduction test","4b","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Adult","M + F","> 1000","In life observation","Body weight (bird)",{"$f":"IF(Z40<>0,VLOOKUP(Z40,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Body weight of hatchlings and 14-day old survivors","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z40<>0,VLOOKUP(Z40,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","4c","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Adult","M + F","> 1000","In life observation","[Not in list]","Sensitive to, but not diagnostic of, EATS","Feed consumption","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z41<>0,VLOOKUP(Z41,Interpretation!$C:$E,3,FALSE),\"\")","v":0},null,"Yes","Yes"]
["Avian","Avian reproduction test","4d","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Adult","F","> 1000","Reproductive","Egg production",{"$f":"IF(Z42<>0,VLOOKUP(Z42,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"No of eggs/hen","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z42<>0,VLOOKUP(Z42,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","4e","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Adult","F","> 1000","Reproductive","Cracked eggs",{"$f":"IF(Z43<>0,VLOOKUP(Z43,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Cracked eggs","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z43<>0,VLOOKUP(Z43,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","4f","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Adult","F","> 1000","Reproductive","Egg viability (% viable embryo of egg set)",{"$f":"IF(Z44<>0,VLOOKUP(Z44,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Egg viability","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z44<>0,VLOOKUP(Z44,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","4g","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Adult","F","> 1000","Reproductive","Eggshell thickness",{"$f":"IF(Z45<>0,VLOOKUP(Z45,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Eggshell thickness","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z45<>0,VLOOKUP(Z45,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","4h","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Adult","F","> 1000","Reproductive","Egg weight","Sensitive to, but not diagnostic of, EATS","Egg weight","Absolute","No effect",1000,"> 1000","ppm","N",null,"Yes","Yes"]
["Avian","Avian reproduction test","4i","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Adult","F","> 1000","Reproductive","Viable embryos",{"$f":"IF(Z47<>0,VLOOKUP(Z47,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Number of eggs set (Day 14); and thereof live 3-week embryos (Day 19)","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z47<>0,VLOOKUP(Z47,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","4j","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Adult","F","> 1000","Reproductive","Hatchability",{"$f":"IF(Z48<>0,VLOOKUP(Z48,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Number of living three-weeks embryos","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z48<>0,VLOOKUP(Z48,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","4k","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Offspring (F1)","M + F","> 1000","Reproductive","No of 14 day-old survivors",{"$f":"IF(Z49<>0,VLOOKUP(Z49,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"of normal hatchlings; per hen","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z49<>0,VLOOKUP(Z49,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","4l","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Offspring (F1)","M + F","> 1000","In life observation","Body weight (bird)",{"$f":"IF(Z50<>0,VLOOKUP(Z50,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Hatchlings, 14-day old survivors","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z50<>0,VLOOKUP(Z50,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish Not il list","5a","RF-D62.16/99","IBAMA 1990; OECD 212","DAR",null,2000,"Brachydanio rerio","n.a.","30/M+F/ group","M + F","954.9 g/kg acid equivalent","Uptake from water","Water","0.32; 0.56; 1.0; 3.2; 5.6; 10; 32","0.32",32,"mg/L",168,"hours","Larval","M + F","3.2","In life observation","Survival (fish)",{"$f":"IF(Z51<>0,VLOOKUP(Z51,Interpretation!$C:$E,2,FALSE),\"\")","v":"Systemic toxicity"},"Survival","Absolute","Decrease",1,"3.2","mg/L",{"$f":"IF(Z51<>0,VLOOKUP(Z51,Interpretation!$C:$E,3,FALSE),\"\")","v":"_"},"10% mortality at 3.2 mg/L (not statistically significant but considered biologically relevant by RMS)","Yes","Yes"]
["Fish","Fish Not il list","5b","RF-D62.16/99","IBAMA 1990; OECD 212","DAR",null,2000,"Brachydanio rerio","n.a.","30/M+F/ group","M + F","954.9 g/kg acid equivalent","Uptake from water","Water","0.32; 0.56; 1.0; 3.2; 5.6; 10; 32","0.32",32,"mg/L",168,"hours","Larval","M + F","3.2","In life observation","Behaviour (fish)",{"$f":"IF(Z52<>0,VLOOKUP(Z52,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Lethargy","Absolute","Increase",1,"3.2","mg/L",{"$f":"IF(Z52<>0,VLOOKUP(Z52,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"No statistics","Yes","Yes"]
["Fish","Fish early life stage toxicity test","6a","2310941 /1005.029.321","OPPTS 850.1400; OECD 210","DAR",null,2010,"Oncorhynchus mykiss","n.a.","40/M+F/group","M + F","96.03","Uptake from water","Water","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","0.064","9.63","mg/L","85 (60 post hatch)","days","Embryo","M + F","> 9.63","In life observation","Hatching success",{"$f":"IF(Z53<>0,VLOOKUP(Z53,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Hatching success based on the number of eggs actually fertilized","Relative","No effect","9.63","> 9.63","mg/L",{"$f":"IF(Z53<>0,VLOOKUP(Z53,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"variability of hatching success at 9.63 mg/L (2 replicates only)\nStudy considered valid by RMS but resuls are unreliable","Yes","Yes"]
["Fish","Fish early life stage toxicity test","6b","2310941 /1005.029.321","OPPTS 850.1400; OECD 210","DAR",null,2010,"Oncorhynchus mykiss","n.a.","40/M+F/group","M + F","96.03","Uptake from water","Water","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","0.064","9.63","mg/L","85 (60 post hatch)","days","Embryo","M + F","> 9.63","Abnormalities","Morphological abnormalities",{"$f":"IF(Z54<>0,VLOOKUP(Z54,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Percent normal fry at hatch","Relative","No effect","9.63","> 9.63","mg/L",{"$f":"IF(Z54<>0,VLOOKUP(Z54,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"Study considered valid by RMS but resuls are unreliable","Yes","Yes"]
["Fish","Fish early life stage toxicity test","6c","2310941 /1005.029.321","OPPTS 850.1400; OECD 210","DAR",null,2010,"Oncorhynchus mykiss","n.a.","40/M+F/group","M + F","96.03","Uptake from water","Water","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","0.064","9.63","mg/L","85 (60 post hatch)","days","Larval","M + F","> 9.63","In life observation","Larval survival and length",{"$f":"IF(Z55<>0,VLOOKUP(Z55,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Survival of larvae 60 DPH","Relative","No effect","9.63","> 9.63","mg/L",{"$f":"IF(Z55<>0,VLOOKUP(Z55,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"variability of egg viability at 9.63 mg/L (2 replicates only). Survival was found to be lower in the control than in the tested concentrations.\nStudy considered valid by RMS but resuls are unreliable","Yes","Yes"]
["Fish","Fish early life stage toxicity test","6d","2310941 /1005.029.321","OPPTS 850.1400; OECD 210","DAR",null,2010,"Oncorhynchus mykiss","n.a.","40/M+F/group","M + F","96.03","Uptake from water","Water","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","0.064","9.63","mg/L","85 (60 post hatch)","days","Larval","M + F","> 9.63","In life observation","Larval survival and length",{"$f":"IF(Z56<>0,VLOOKUP(Z56,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Length of larvae 60 DPH","Absolute","No effect","9.63","> 9.63","mg/L",{"$f":"IF(Z56<>0,VLOOKUP(Z56,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"Study considered valid by RMS but resuls are unreliable","Yes","Yes"]
["Fish","Fish early life stage toxicity test","6e","2310941 /1005.029.321","OPPTS 850.1400; OECD 210","DAR",null,2010,"Oncorhynchus mykiss","n.a.","40/M+F/group","M + F","96.03","Uptake from water","Water","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","0.064","9.63","mg/L","85 (60 post hatch)","days","Larval","M + F","> 9.63","In life observation","Body weight (fish)",{"$f":"IF(Z57<>0,VLOOKUP(Z57,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Wet and dry weight of larvae 60 DPH","Absolute","No effect","9.63","> 9.63","mg/L",{"$f":"IF(Z57<>0,VLOOKUP(Z57,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"variability of wet and dry weight in control and at 9.63 mg/L (2 replicates only)\nStudy considered valid by RMS but resuls are unreliable","Yes","Yes"]
["Fish","Fish life cycle toxicity test","7a","BN-75-129","EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","60 eggs/group","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Embryo","M + F","> 25.7","Reproductive","Hatching success",{"$f":"IF(Z58<>0,VLOOKUP(Z58,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Hatching success","Relative","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z58<>0,VLOOKUP(Z58,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"Number of eggs spawned per female and number of eggs per spawning with high variability (duplicate) particularly in control and highest tested dose\n2 replicates per concentations.\nderivatisation efficiency of this analytical method can not be verified by RMS.\nStudy considered supportive","Yes","Yes"]
["Fish","Fish life cycle toxicity test","7b","BN-75-129","EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","40/M+F/group","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Adult","M + F","> 25.7","In life observation","Survival (fish)",{"$f":"IF(Z59<>0,VLOOKUP(Z59,Interpretation!$C:$E,2,FALSE),\"\")","v":"Systemic toxicity"},"At days 30 and 60","Relative","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z59<>0,VLOOKUP(Z59,Interpretation!$C:$E,3,FALSE),\"\")","v":"_"},"derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes"]
["Fish","Fish life cycle toxicity test","7c","BN-75-129","EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","40/M+F/group","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Adult","M + F","> 25.7","In life observation","Length (fish)",{"$f":"IF(Z60<>0,VLOOKUP(Z60,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"At days 30 and 60","Absolute","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z60<>0,VLOOKUP(Z60,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes"]
["Fish","Fish life cycle toxicity test","7d","BN-75-129","EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","40/M+F/group","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Adult","M + F","> 25.7","In life observation","Body weight (fish)",{"$f":"IF(Z61<>0,VLOOKUP(Z61,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"At days 30 and 60","Absolute","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z61<>0,VLOOKUP(Z61,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes"]
["Fish","Fish life cycle toxicity test","7e","BN-75-129","EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","12/M+F/group (2M+4F/replicate)","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Adult","F","> 25.7","In life observation","Length (fish)",{"$f":"IF(Z62<>0,VLOOKUP(Z62,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"At test termination ","Absolute","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z62<>0,VLOOKUP(Z62,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes"]
["Fish","Fish life cycle toxicity test","7f","BN-75-129","EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","12/M+F/group (2M+4F/replicate)","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Adult","F","> 25.7","In life observation","Body weight (fish)",{"$f":"IF(Z63<>0,VLOOKUP(Z63,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"At test termination ","Absolute","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z63<>0,VLOOKUP(Z63,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes"]
["Fish","Fish life cycle toxicity test","7g","BN-75-129","EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","12/M+F/group (2M+4F/replicate)","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Adult","F","> 25.7","Reproductive","Reproduction (fecundity, fertility)",{"$f":"IF(Z64<>0,VLOOKUP(Z64,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Eggs/F, eggs/spawn","Absolute","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z64<>0,VLOOKUP(Z64,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes"]
["Fish","Fish life cycle toxicity test","7h","BN-75-129","EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","50 eggs/group","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Offspring (F1)","F","> 25.7","Reproductive","Hatching success",{"$f":"IF(Z65<>0,VLOOKUP(Z65,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Hatching success","Relative","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z65<>0,VLOOKUP(Z65,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes"]
["Fish","Fish life cycle toxicity test","7i","BN-75-129","EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","40 fry/group","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Offspring (F1)","M + F","> 25.7","In life observation","Survival (fish)",{"$f":"IF(Z66<>0,VLOOKUP(Z66,Interpretation!$C:$E,2,FALSE),\"\")","v":"Systemic toxicity"},"Offspring survival","Relative","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z66<>0,VLOOKUP(Z66,Interpretation!$C:$E,3,FALSE),\"\")","v":"_"},"derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes"]
["Fish","Fish life cycle toxicity test","7j","BN-75-129","EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","40 fry/group","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Offspring (F1)","M + F","> 25.7","In life observation","Length (fish)",{"$f":"IF(Z67<>0,VLOOKUP(Z67,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Offspring length","Absolute","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z67<>0,VLOOKUP(Z67,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes"]
["Fish","Fish life cycle toxicity test","7k","BN-75-129","EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","40 fry/group","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Offspring (F1)","M + F","> 25.7","In life observation","Body weight (fish)",{"$f":"IF(Z68<>0,VLOOKUP(Z68,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Offspring body weight","Absolute","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z68<>0,VLOOKUP(Z68,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes"]
["Fish","Fish short-term reproduction assay","8a","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","M + F","> 33","In life observation","Survival (fish)",{"$f":"IF(Z69<>0,VLOOKUP(Z69,Interpretation!$C:$E,2,FALSE),\"\")","v":"Systemic toxicity"},"Survival ","Relative","No effect",33,"> 33","mg/L",{"$f":"IF(Z69<>0,VLOOKUP(Z69,Interpretation!$C:$E,3,FALSE),\"\")","v":"_"},null,"Yes","Yes"]
["Fish","Fish short-term reproduction assay","8b","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","M + F","> 33","In life observation","Length (fish)",{"$f":"IF(Z70<>0,VLOOKUP(Z70,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Length","Absolute","No effect",33,"> 33","mg/L",{"$f":"IF(Z70<>0,VLOOKUP(Z70,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish short-term reproduction assay","8c","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","M + F","> 33","In life observation","Body weight (fish)",{"$f":"IF(Z71<>0,VLOOKUP(Z71,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Body weight","Absolute","No effect",33,"> 33","mg/L",{"$f":"IF(Z71<>0,VLOOKUP(Z71,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish short-term reproduction assay","8d","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","F","> 33","Reproductive","Reproduction (fecundity, fertility)",{"$f":"IF(Z72<>0,VLOOKUP(Z72,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Cumulative number of eggs/number of eggs per female reproductive day ","Absolute","No effect",33,"> 33","mg/L",{"$f":"IF(Z72<>0,VLOOKUP(Z72,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish short-term reproduction assay","8e","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","F","> 33","Reproductive","Male 2nd sex characteristics in females",{"$f":"IF(Z73<>0,VLOOKUP(Z73,Interpretation!$C:$E,2,FALSE),\"\")","v":"EATS-mediated"},"M: pigmentation patterns, tubercles, fatpads; F: ovipositors","Absolute","No effect",33,"> 33","mg/L",{"$f":"IF(Z73<>0,VLOOKUP(Z73,Interpretation!$C:$E,3,FALSE),\"\")","v":"A"},null,"Yes","Yes"]
["Fish","Fish short-term reproduction assay","8f","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","M","> 33","Reproductive","Male 2nd sex characteristics in males",{"$f":"IF(Z74<>0,VLOOKUP(Z74,Interpretation!$C:$E,2,FALSE),\"\")","v":"EATS-mediated"},"M: pigmentation patterns, tubercles, fatpads; F: ovipositors","Absolute","No effect",33,"> 33","mg/L",{"$f":"IF(Z74<>0,VLOOKUP(Z74,Interpretation!$C:$E,3,FALSE),\"\")","v":"E, A, S"},null,"Yes","Yes"]
["Fish","Fish short-term reproduction assay","8g","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","M + F","> 33","Reproductive","Gonado-somatic index",{"$f":"IF(Z75<>0,VLOOKUP(Z75,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"GSI","Absolute","No effect",33,"> 33","mg/L",{"$f":"IF(Z75<>0,VLOOKUP(Z75,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish short-term reproduction assay","8h","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","F","> 33","Clinical chemistry/hormones","Vitellogenin (VTG) in females",{"$f":"IF(Z76<>0,VLOOKUP(Z76,Interpretation!$C:$E,2,FALSE),\"\")","v":"In vivo mechanistic"},"VTG in females","Absolute","No effect",33,"> 33","mg/L",{"$f":"IF(Z76<>0,VLOOKUP(Z76,Interpretation!$C:$E,3,FALSE),\"\")","v":"E, A, S"},"Non-significant ↓ in all treatments","Yes","Yes"]
["Fish","Fish short-term reproduction assay","8i","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","M","> 33","Clinical chemistry/hormones","Vitellogenin (VTG) in males",{"$f":"IF(Z77<>0,VLOOKUP(Z77,Interpretation!$C:$E,2,FALSE),\"\")","v":"In vivo mechanistic"},"VTG in males","Absolute","No effect",33,"> 33","mg/L",{"$f":"IF(Z77<>0,VLOOKUP(Z77,Interpretation!$C:$E,3,FALSE),\"\")","v":"E, A, S"},"Non-significant ↓ at 6.2 and 33 mg/L","Yes","Yes"]
["Fish","Fish short-term reproduction assay","8j","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","M + F","> 33","Organ histopathology","Specific gonad histopathology",{"$f":"IF(Z78<>0,VLOOKUP(Z78,Interpretation!$C:$E,2,FALSE),\"\")","v":"EATS-mediated"},"Histopathology from testes and ovaries","Absolute","No effect",33,"> 33","mg/L",{"$f":"IF(Z78<>0,VLOOKUP(Z78,Interpretation!$C:$E,3,FALSE),\"\")","v":"E, A, S"},null,"Yes","Yes"]
["Amphibian","Amphibian metamorphosis assay","9a","707A-103","OPPTS 890.1100, OECD 231","DAR",null,2012,"Xenopus laevis","n.a.","80 tadpoles/M+F/ group","M + F","85.14","Uptake from water","Water","0.13; 0.79; 4.3; 20; 90 (mean measured)","0.13",90,"mg/L",21,"days","Tadpole","M + F","> 90","In life observation","Mortality (amphibian)",{"$f":"IF(Z79<>0,VLOOKUP(Z79,Interpretation!$C:$E,2,FALSE),\"\")","v":"Systemic toxicity"},"Mortality","Relative","No effect",90,"> 90","mg/L",{"$f":"IF(Z79<>0,VLOOKUP(Z79,Interpretation!$C:$E,3,FALSE),\"\")","v":"_"},null,"Yes","Yes"]
["Amphibian","Amphibian metamorphosis assay","9b","707A-103","OPPTS 890.1100, OECD 231","DAR",null,2012,"Xenopus laevis","n.a.","80 tadpoles/M+F/ group","M + F","85.14","Uptake from water","Water","0.13; 0.79; 4.3; 20; 90 (mean measured)","0.13",90,"mg/L",21,"days","Tadpole","M + F","> 90","Abnormalities","Malformations",{"$f":"IF(Z80<>0,VLOOKUP(Z80,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Malformations","Absolute","No effect",90,"> 90","mg/L",{"$f":"IF(Z80<>0,VLOOKUP(Z80,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"Tail curvature is considered as a dietary effect","Yes","Yes"]
["Amphibian","Amphibian metamorphosis assay","9c","707A-103","OPPTS 890.1100, OECD 231","DAR",null,2012,"Xenopus laevis","n.a.","80 tadpoles/M+F/ group","M + F","85.14","Uptake from water","Water","0.13; 0.79; 4.3; 20; 90 (mean measured)","0.13",90,"mg/L",21,"days","Tadpole","M + F","> 90","Developmental","Developmental stage",{"$f":"IF(Z81<>0,VLOOKUP(Z81,Interpretation!$C:$E,2,FALSE),\"\")","v":"EATS-mediated"},"Developmental stage","Absolute","No effect",90,"> 90","mg/L",{"$f":"IF(Z81<>0,VLOOKUP(Z81,Interpretation!$C:$E,3,FALSE),\"\")","v":"T"},null,"Yes","Yes"]
["Amphibian","Amphibian metamorphosis assay","9d","707A-103","OPPTS 890.1100, OECD 231","DAR",null,2012,"Xenopus laevis","n.a.","80 tadpoles/M+F/ group","M + F","85.14","Uptake from water","Water","0.13; 0.79; 4.3; 20; 90 (mean measured)","0.13",90,"mg/L",21,"days","Tadpole","M + F",90,"In life observation","Body weight (amphibian)",{"$f":"IF(Z82<>0,VLOOKUP(Z82,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Wet weight","Absolute","Increase",20,90,"mg/L",{"$f":"IF(Z82<>0,VLOOKUP(Z82,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"90 mg/L: Increase by 15% compared to control","Yes","Yes"]
["Amphibian","Amphibian metamorphosis assay","9e","707A-103","OPPTS 890.1100, OECD 231","DAR",null,2012,"Xenopus laevis","n.a.","80 tadpoles/M+F/ group","M + F","85.14","Uptake from water","Water","0.13; 0.79; 4.3; 20; 90 (mean measured)","0.13",90,"mg/L",21,"days","Tadpole","M + F","4.3","In life observation","Snout-vent length/growth",{"$f":"IF(Z83<>0,VLOOKUP(Z83,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Snout-vent length/growth","Absolute","Increase","0.79","4.3","mg/L",{"$f":"IF(Z83<>0,VLOOKUP(Z83,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"Snout-vent length: significantly increased by 5 and 7% at 4.3 and 90 mg/L and a significant trend (increase) by 2.5 % at 20 mg/L","Yes","Yes"]
["Amphibian","Amphibian metamorphosis assay","9f","707A-103","OPPTS 890.1100, OECD 231","DAR",null,2012,"Xenopus laevis","n.a.","80 tadpoles/M+F/ group","M + F","85.14","Uptake from water","Water","0.13; 0.79; 4.3; 20; 90 (mean measured)","0.13",90,"mg/L",21,"days","Tadpole","M + F","> 90","Developmental","Hind limb length",{"$f":"IF(Z84<>0,VLOOKUP(Z84,Interpretation!$C:$E,2,FALSE),\"\")","v":"EATS-mediated"},"Hind limb length","Absolute","No effect",90,"> 90","mg/L",{"$f":"IF(Z84<>0,VLOOKUP(Z84,Interpretation!$C:$E,3,FALSE),\"\")","v":"T"},null,"Yes","Yes"]
["Amphibian","Amphibian metamorphosis assay","9g","707A-103","OPPTS 890.1100, OECD 231","DAR",null,2012,"Xenopus laevis","n.a.","80 tadpoles/M+F/ group","M + F","85.14","Uptake from water","Water","0.13; 0.79; 4.3; 20; 90 (mean measured)","0.13",90,"mg/L",21,"days","Tadpole","M + F","> 90","Organ histopathology","Thyroid histopathology (amphibian)",{"$f":"IF(Z85<>0,VLOOKUP(Z85,Interpretation!$C:$E,2,FALSE),\"\")","v":"EATS-mediated"},"Thyroid histopathology","Absolute","No effect",90,"> 90","mg/L",{"$f":"IF(Z85<>0,VLOOKUP(Z85,Interpretation!$C:$E,3,FALSE),\"\")","v":"T"},null,"Yes","Yes"]
["Fish","[Toxicity test not in list]","15a",null,"Not stated","publication","Le Mer, C. et al. ",2013,"Gasterosteus aculeatus","n.a.","27-30/M+F/group","M + F","≥  96","Uptake from water","Water","0.1; 1; 10; 100","0.1","100","mg/L",42,"days","Juvenile","M + F","> 100","In life observation","Length (fish)",{"$f":"IF(Z86<>0,VLOOKUP(Z86,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Fish length","Absolute","No effect","≥ 100","> 100","mg/L",{"$f":"IF(Z86<>0,VLOOKUP(Z86,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"seawater used in the test (this fish species can be found in both freshwater and sea), interactions between the ions and the active substance cannot be discounted","Yes","Yes"]
["Fish","[Toxicity test not in list]","15b",null,"Not stated","publication","Le Mer, C. et al. ",2013,"Gasterosteus aculeatus","n.a.","27-30/M+F/group","M + F","≥  96","Uptake from water","Water","0.1; 1; 10; 100","0.1","100","mg/L",42,"days","Juvenile","M + F","> 100","In life observation","Body weight (fish)",{"$f":"IF(Z87<>0,VLOOKUP(Z87,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Fish wet weight","Absolute","No effect","≥ 100","> 100","mg/L",{"$f":"IF(Z87<>0,VLOOKUP(Z87,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"seawater used in the test (this fish species can be found in both freshwater and sea), interactions between the ions and the active substance cannot be discounted","Yes","Yes"]
["Fish","[Toxicity test not in list]","15c",null,"Not stated","publication","Le Mer, C. et al. ",2013,"Gasterosteus aculeatus","n.a.","27-30/M+F/group","M + F","≥  96","Uptake from water","Water","0.1; 1; 10; 100","0.1","100","mg/L",42,"days","Juvenile","M + F","> 100","Clinical chemistry/hormones","[Not in list]","In vivo mechanistic","VTG induction in fish","Not reported","No effect","≥ 100","> 100","mg/L","E, A, S","Fish were pooled for VTG analysis. No differentiation between males and females.\nseawater used in the test (this fish species can be found in both freshwater and sea), interactions between the ions and the active substance cannot be discounted","Yes","Yes"]
["Fish","[Toxicity test not in list]","15d",null,"Not stated","publication","Le Mer, C. et al. ",2013,"Gasterosteus aculeatus","n.a.","27-30/M+F/group","M + F","≥  96","Uptake from water","Water","0.1; 1; 10; 100","0.1","100","mg/L",42,"days","Juvenile","M + F","> 100","Reproductive","Sex ratio","EATS-mediated","Sex ratio in juvenile fish","Not reported","No effect","≥ 100","> 100","mg/L","E, A, S","Evaluated by gonad histology.\nseawater used in the test (this fish species can be found in both freshwater and sea), interactions between the ions and the active substance cannot be discounted","Yes","Yes"]
["Fish","[Toxicity test not in list]","15e",null,"Not stated","publication","Le Mer, C. et al. ",2013,"Gasterosteus aculeatus","n.a.","27-30/M+F/group","M + F","≥  96","Uptake from water","Water","0.1; 1; 10; 100","0.1","100","mg/L",42,"days","Juvenile","M + F","> 100","Clinical chemistry/hormones","Spiggin",{"$f":"IF(Z90<>0,VLOOKUP(Z90,Interpretation!$C:$E,2,FALSE),\"\")","v":"In vivo mechanistic"},"Spiggin in juvenile fish","Not reported","No effect","≥ 100","> 100","mg/L","A","No induction of spiggin was observed in the positive dihydrotestosterone control. Therefore, the results on spiggin induction are considered as not reliable and not considered within the further evaluation.\nseawater used in the test (this fish species can be found in both freshwater and sea), interactions between the ions and the active substance cannot be discounted","Yes","No"]
["[Toxicity test not in list]","[Toxicity test not in list]","16a","20FV2ME","OECD 219","DAR",null,2020,"Chironomus riparius","n.a.","160/M+F/group","M + F","97.7","Uptake from water","Water","100; 1000","100","100","mg/L",28,"days","Adult","M + F","> 1000","In life observation","[Not in list]","Sensitive to, but not diagnostic of, EATS","Emergence ratio of chironomids","Relative","No effect","≥ 1000","> 1000","mg/L","N","study considered as supportive only (non analytics in sediment. Glyphosate partition to sediment)","Yes","Yes"]
["[Toxicity test not in list]","[Toxicity test not in list]","16b","20FV2ME","OECD 219","DAR",null,2020,"Chironomus riparius","n.a.","160/M+F/group","M + F","97.7","Uptake from water","Water","100; 1000","100","100","mg/L",28,"days","Adult","M + F","> 1000","In life observation","[Not in list]","Sensitive to, but not diagnostic of, EATS","Developmental rate of chironomids","Absolute","No effect","≥ 1000","> 1000","mg/L","N","study considered as supportive only (non analytics in sediment. Glyphosate partition to sediment)","Yes","Yes"]
["[Toxicity test not in list]","[Toxicity test not in list]","16c","20FV2ME","OECD 219","DAR",null,2020,"Chironomus riparius","n.a.","160/M+F/group","M + F","97.7","Uptake from water","Water","100; 1000",100,"100","mg/L",28,"days","Adult","M + F","> 1000","In life observation","Sex ratio","EATS-mediated","Sex ratio in chironomids","Relative","No effect","≥ 1000","> 1000","mg/L","N","study considered as supportive only (non analytics in sediment. Glyphosate partition to sediment)","Yes","Yes"]

{"sheet":"Data summary_RMS","index":10,"n_rows":93,"n_cols":52,"rows_kept":93,"cut":false,"hidden":false,"merged":[[3,15,3,51],[90,0,90,14],[91,0,91,14],[92,0,92,14]]}
[]
[]
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[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Insert a sorting number (1 .. n) on targets loading as lines of evidence"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"In vivo mechanistic","In vivo mechanistic","In vivo mechanistic","In vivo mechanistic","EATS-mediated","EATS-mediated","EATS-mediated","EATS-mediated","EATS-mediated","EATS-mediated","EATS-mediated","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Systemic toxicity","Systemic toxicity","Systemic toxicity"]
["Study ID Matrix","Source","Year","Type of toxicity","Study Principle","Species","Doses tested","Dose unit","Route of administration","Exposure","Exposure unit","Generation/Life stage","Additional remarks","Relevance","Reliability","[Not in list]","Spiggin","Vitellogenin (VTG) in females","Vitellogenin (VTG) in males","Developmental stage","Hind limb length","Male 2nd sex characteristics in females","Male 2nd sex characteristics in males","Sex ratio","Specific gonad histopathology","Thyroid histopathology (amphibian)","[Not in list]","Behaviour (fish)","Body weight (amphibian)","Body weight (bird)","Body weight (fish)","Cracked eggs","Egg production","Egg viability (% viable embryo of egg set)","Egg weight","Eggshell thickness","Gonado-somatic index","Gross pathology (bird)","Hatchability","Hatching success","Larval survival and length","Length (fish)","Malformations","Morphological abnormalities","No of 14 day-old survivors","Reproduction (fecundity, fertility)","Snout-vent length/growth","Viable embryos","Mortality","Mortality (amphibian)","Survival (fish)"]
["5a","DAR",2000,"Fish","Fish Not il list","Brachydanio rerio","0.32; 0.56; 1.0; 3.2; 5.6; 10; 32","mg/L","Uptake from water",168,"hours","Larval","10% mortality at 3.2 mg/L (not statistically significant but considered biologically relevant by RMS)","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Decrease 3.2 (Survival, Absolute)"]
["5b","DAR",2000,"Fish","Fish Not il list","Brachydanio rerio","0.32; 0.56; 1.0; 3.2; 5.6; 10; 32","mg/L","Uptake from water",168,"hours","Larval","No statistics","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,"Increase 3.2 (Lethargy, Absolute)"]
["15a","publication",2013,"Fish","[Toxicity test not in list]","Gasterosteus aculeatus","0.1; 1; 10; 100","mg/L","Uptake from water",42,"days","Juvenile","seawater used in the test (this fish species can be found in both freshwater and sea), interactions between the ions and the active substance cannot be discounted","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 100 (Fish length, Absolute)"]
["15b","publication",2013,"Fish","[Toxicity test not in list]","Gasterosteus aculeatus","0.1; 1; 10; 100","mg/L","Uptake from water",42,"days","Juvenile","seawater used in the test (this fish species can be found in both freshwater and sea), interactions between the ions and the active substance cannot be discounted","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 100 (Fish wet weight, Absolute)"]
["15c","publication",2013,"Fish","[Toxicity test not in list]","Gasterosteus aculeatus","0.1; 1; 10; 100","mg/L","Uptake from water",42,"days","Juvenile","Fish were pooled for VTG analysis. No differentiation between males and females.\nseawater used in the test (this fish species can be found in both freshwater and sea), interactions between the ions and the active substance cannot be discounted","Yes","Yes","No effect > 100 (VTG induction in fish, Not reported)"]
["15d","publication",2013,"Fish","[Toxicity test not in list]","Gasterosteus aculeatus","0.1; 1; 10; 100","mg/L","Uptake from water",42,"days","Juvenile","Evaluated by gonad histology.\nseawater used in the test (this fish species can be found in both freshwater and sea), interactions between the ions and the active substance cannot be discounted","Yes","Yes",null,null,null,null,null,null,null,null,"No effect > 100 (Sex ratio in juvenile fish, Not reported)"]
["15e","publication",2013,"Fish","[Toxicity test not in list]","Gasterosteus aculeatus","0.1; 1; 10; 100","mg/L","Uptake from water",42,"days","Juvenile","No induction of spiggin was observed in the positive dihydrotestosterone control. Therefore, the results on spiggin induction are considered as not reliable and not considered within the further evaluation.\nseawater used in the test (this fish species can be found in both freshwater and sea), interactions between the ions and the active substance cannot be discounted","Yes","No",null,"No effect > 100 (Spiggin in juvenile fish, Not reported)"]
["6a","DAR",2010,"Fish","Fish early life stage toxicity test","Oncorhynchus mykiss","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","mg/L","Uptake from water","85 (60 post hatch)","days","Embryo","variability of hatching success at 9.63 mg/L (2 replicates only)\nstudy considered supportive","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 9.63 (Hatching success based on the number of eggs actually fertilized, Relative)"]
["6b","DAR",2010,"Fish","Fish early life stage toxicity test","Oncorhynchus mykiss","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","mg/L","Uptake from water","85 (60 post hatch)","days","Embryo",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 9.63 (Percent normal fry at hatch, Relative)"]
["6c","DAR",2010,"Fish","Fish early life stage toxicity test","Oncorhynchus mykiss","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","mg/L","Uptake from water","85 (60 post hatch)","days","Larval","variability of egg viability at 9.63 mg/L (2 replicates only). Survival was found to be lower in the control than in the tested concentrations.\nstudy considered supportive","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 9.63 (Survival of larvae 60 DPH, Relative)"]
["6d","DAR",2010,"Fish","Fish early life stage toxicity test","Oncorhynchus mykiss","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","mg/L","Uptake from water","85 (60 post hatch)","days","Larval",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 9.63 (Length of larvae 60 DPH, Absolute)"]
["6e","DAR",2010,"Fish","Fish early life stage toxicity test","Oncorhynchus mykiss","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","mg/L","Uptake from water","85 (60 post hatch)","days","Larval","variability of wet and dry weight in control and at 9.63 mg/L (2 replicates only)\nstudy considered supportive","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 9.63 (Wet and dry weight of larvae 60 DPH, Absolute)"]
["7a","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Embryo","Number of eggs spawned per female and number of eggs per spawning with high variability (duplicate) particularly in control and highest tested dose\n2 replicates per concentations.\nderivatisation efficiency of this analytical method can not be verified by RMS.\nStudy considered supportive","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (Hatching success, Relative)"]
["7b","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Adult","derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (At days 30 and 60, Relative)"]
["7c","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Adult","derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (At days 30 and 60, Absolute)"]
["7d","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Adult","derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (At days 30 and 60, Absolute)"]
["7e","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Adult","derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (At test termination , Absolute)"]
["7f","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Adult","derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (At test termination , Absolute)"]
["7g","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Adult","derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (Eggs/F, eggs/spawn, Absolute)"]
["7h","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Offspring (F1)","derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (Hatching success, Relative)"]
["7i","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Offspring (F1)","derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (Offspring survival, Relative)"]
["7j","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Offspring (F1)","derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (Offspring length, Absolute)"]
["7k","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Offspring (F1)","derivatisation efficiency of this analytical method can not be verified by RMS.\n2 replicates per concentations.\nStudy considered supportive","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (Offspring body weight, Absolute)"]
["8a","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 33 (Survival , Relative)"]
["8b","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 33 (Length, Absolute)"]
["8c","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 33 (Body weight, Absolute)"]
["8d","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 33 (Cumulative number of eggs/number of eggs per female reproductive day , Absolute)"]
["8e","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,"No effect > 33 (M: pigmentation patterns, tubercles, fatpads; F: ovipositors, Absolute)"]
["8f","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,"No effect > 33 (M: pigmentation patterns, tubercles, fatpads; F: ovipositors, Absolute)"]
["8g","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 33 (GSI, Absolute)"]
["8h","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult","Non-significant ↓ in all treatments","Yes","Yes",null,null,"No effect > 33 (VTG in females, Absolute)"]
["8i","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult","Non-significant ↓ at 6.2 and 33 mg/L","Yes","Yes",null,null,null,"No effect > 33 (VTG in males, Absolute)"]
["8j","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,"No effect > 33 (Histopathology from testes and ovaries, Absolute)"]
["9a","DAR",2012,"Amphibian","Amphibian metamorphosis assay","Xenopus laevis","0.13; 0.79; 4.3; 20; 90 (mean measured)","mg/L","Uptake from water",21,"days","Tadpole",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 90 (Mortality, Relative)"]
["9b","DAR",2012,"Amphibian","Amphibian metamorphosis assay","Xenopus laevis","0.13; 0.79; 4.3; 20; 90 (mean measured)","mg/L","Uptake from water",21,"days","Tadpole","Tail curvature is considered as a dietary effect","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 90 (Malformations, Absolute)"]
["9c","DAR",2012,"Amphibian","Amphibian metamorphosis assay","Xenopus laevis","0.13; 0.79; 4.3; 20; 90 (mean measured)","mg/L","Uptake from water",21,"days","Tadpole",null,"Yes","Yes",null,null,null,null,"No effect > 90 (Developmental stage, Absolute)"]
["9d","DAR",2012,"Amphibian","Amphibian metamorphosis assay","Xenopus laevis","0.13; 0.79; 4.3; 20; 90 (mean measured)","mg/L","Uptake from water",21,"days","Tadpole","90 mg/L: Increase by 15% compared to control","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,"Increase 90 (Wet weight, Absolute)"]
["9e","DAR",2012,"Amphibian","Amphibian metamorphosis assay","Xenopus laevis","0.13; 0.79; 4.3; 20; 90 (mean measured)","mg/L","Uptake from water",21,"days","Tadpole","Snout-vent length: significantly increased by 5 and 7% at 4.3 and 90 mg/L and a significant trend (increase) by 2.5 % at 20 mg/L","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Increase 4.3 (Snout-vent length/growth, Absolute)"]
["9f","DAR",2012,"Amphibian","Amphibian metamorphosis assay","Xenopus laevis","0.13; 0.79; 4.3; 20; 90 (mean measured)","mg/L","Uptake from water",21,"days","Tadpole",null,"Yes","Yes",null,null,null,null,null,"No effect > 90 (Hind limb length, Absolute)"]
["9g","DAR",2012,"Amphibian","Amphibian metamorphosis assay","Xenopus laevis","0.13; 0.79; 4.3; 20; 90 (mean measured)","mg/L","Uptake from water",21,"days","Tadpole",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,"No effect > 90 (Thyroid histopathology, Absolute)"]
["2a","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Mortality, Absolute)"]
["2b","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Body weight, Absolute)"]
["2c","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Clinical observations, behaviour, Absolute)"]
["2d","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Feed consumption, Absolute)"]
["2e","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Gross necropsy of survivors, Absolute)"]
["2f","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Eggs/female divided by maximum laid, Absolute)"]
["2g","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Cracked eggs, Relative)"]
["2h","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Candled at Day 11 or 12, Relative)"]
["2i","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Eggshell thickness, Absolute)"]
["2j","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Live embryos at Day 21, Relative)"]
["2k","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (of live 3-week embryos; of eggs set; of maximum set, Absolute)"]
["2l","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Offspring (F1)",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Number of 14-day-old survivors , Relative)"]
["2m","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Offspring (F1)","Significant decrease at 2250 ppm but at level of control of a different, parallel mallard study","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Decrease 2250 (Body weight of 14 -day old survivors, Absolute)"]
["4b","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Body weight of hatchlings and 14-day old survivors, Absolute)"]
["4c","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Feed consumption, Absolute)"]
["4d","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (No of eggs/hen, Absolute)"]
["4e","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Cracked eggs, Absolute)"]
["4f","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Egg viability, Absolute)"]
["4g","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Eggshell thickness, Absolute)"]
["4h","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Egg weight, Absolute)"]
["4i","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Number of eggs set (Day 14); and thereof live 3-week embryos (Day 19), Absolute)"]
["4j","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Number of living three-weeks embryos, Absolute)"]
["4k","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Offspring (F1)",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (of normal hatchlings; per hen, Absolute)"]
["4l","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Offspring (F1)",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Hatchlings, 14-day old survivors, Absolute)"]
["1a","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Adult","After Week 19: \"hysteria attack\", 6 mortalities in control, 2 mortalities in each treatment","No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Mortality, Relative)"]
["1b","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Adult","In Week 8: statistical increase in male bw at 500","No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Body weight, Absolute)"]
["1c","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Adult",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Clinical observations, behaviour, Absolute)"]
["1d","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Adult",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Feed consumption, Absolute)"]
["1e","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Adult",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Gross necropsy of survivors, Absolute)"]
["1f","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Adult",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Eggs/female divided by maximum laid, Relative)"]
["1g","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Adult",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Cracked eggs, Relative)"]
["1h","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Adult",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Candled at Day 11 or 12, Relative)"]
["1i","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Adult",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Eggshell thickness, Absolute)"]
["1j","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Offspring (F1)",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Live embryos at Day 21, Absolute)"]
["1k","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Offspring (F1)",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (of live 3-week embryos; of eggs set; of maximum set, Absolute)"]
["1l","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Offspring (F1)",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (of hatchlings; of eggs set; of maximum set, Relative)"]
["1m","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Offspring (F1)",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (14-day old survivors, Absolute)"]
["16a","DAR",2020,"[Toxicity test not in list]","[Toxicity test not in list]","Chironomus riparius","100; 1000","mg/L","Uptake from water",28,"days","Adult","study considered as supportive only (non analytics in sediment. Glyphosate partition to sediment)","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Emergence ratio of chironomids, Relative)"]
["16b","DAR",2020,"[Toxicity test not in list]","[Toxicity test not in list]","Chironomus riparius","100; 1000","mg/L","Uptake from water",28,"days","Adult","study considered as supportive only (non analytics in sediment. Glyphosate partition to sediment)","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Developmental rate of chironomids, Absolute)"]
["16c","DAR",2020,"[Toxicity test not in list]","[Toxicity test not in list]","Chironomus riparius","100; 1000","mg/L","Uptake from water",28,"days","Adult","study considered as supportive only (non analytics in sediment. Glyphosate partition to sediment)","Yes","Yes",null,null,null,null,null,null,null,null,"No effect > 1000 (Sex ratio in chironomids, Relative)"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null," "]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"[Not in list]","Spiggin","Vitellogenin (VTG) in females","Vitellogenin (VTG) in males","Developmental stage","Hind limb length","Male 2nd sex characteristics in females","Male 2nd sex characteristics in males","Sex ratio","Specific gonad histopathology","Thyroid histopathology (amphibian)","[Not in list]","Behaviour (fish)","Body weight (amphibian)","Body weight (bird)","Body weight (fish)","Cracked eggs","Egg production","Egg viability (% viable embryo of egg set)","Egg weight","Eggshell thickness","Gonado-somatic index","Gross pathology (bird)","Hatchability","Hatching success","Larval survival and length","Length (fish)","Malformations","Morphological abnormalities","No of 14 day-old survivors","Reproduction (fecundity, fertility)","Snout-vent length/growth","Viable embryos","Mortality","Mortality (amphibian)","Survival (fish)"]
["Effect",null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0]
["No effect",null,null,null,null,null,null,null,null,null,null,null,null,null,null,1,1,1,1,1,1,1,1,2,1,1,7,0,0,5,6,3,3,3,1,3,1,2,3,3,2,5,1,1,3,2,0,3,2,1,3,0]
["Not classified",null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2]

{"sheet":"Lines of evidence_RMS","index":11,"n_rows":93,"n_cols":15,"rows_kept":93,"cut":false,"hidden":false,"merged":[]}
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
["Study ID Matrix","Effect classification","Effect target","Species","Duration of exposure","Duration unit","Route of administration","Lowest Effect dose","Dose unit","Effect direction","Observed effect (positive and negative)","Assessment of each line of evidence","Assessment on the integrated line of evidence","Sort","Modality"]
["8h","In vivo mechanistic","Vitellogenin (VTG) in females","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C12,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"E,A,S"]
["8i","In vivo mechanistic","Vitellogenin (VTG) in males","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C13,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"E,A,S"]
["15c","In vivo mechanistic","VTG induction in fish","Gasterosteus aculeatus",42,"days","Uptake from water","> 100","mg/L","No effect",null,null,null,null,"E,A,S"]
["15e","In vivo mechanistic","Spiggin","Gasterosteus aculeatus",42,"days","Uptake from water","> 100","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C15,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"A"]
["8e","EATS-mediated","Male 2nd sex characteristics in females","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C16,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"A"]
["8f","EATS-mediated","Male 2nd sex characteristics in males","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C17,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"E,A,S"]
["8j","EATS-mediated","Specific gonad histopathology","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C18,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"E,A,S"]
["9c","EATS-mediated","Developmental stage","Xenopus laevis",21,"days","Uptake from water","> 90","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C19,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"T"]
["9f","EATS-mediated","Hind limb length","Xenopus laevis",21,"days","Uptake from water","> 90","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C20,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"T"]
["9g","EATS-mediated","Thyroid histopathology (amphibian)","Xenopus laevis",21,"days","Uptake from water","> 90","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C21,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"T"]
["15d","EATS-mediated","Sex ratio","Gasterosteus aculeatus",42,"days","Uptake from water","> 100","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C22,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"E,A,S"]
["16c","EATS-mediated","Sex ratio","Chironomus riparius",28,"days","Uptake from water","> 1000","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C23,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"E,A,S"]
["1b","Sensitive to, but not diagnostic of, EATS","Adult body weight (bird)","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect",null,null,null,null,"N"]
["1c","Sensitive to, but not diagnostic of, EATS","Clinical observations,  behaviour","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect",null,null,null,null,"N"]
["1d","Sensitive to, but not diagnostic of, EATS","Food consumption","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect",null,null,null,null,"N"]
["1e","Sensitive to, but not diagnostic of, EATS","Gross pathology (bird)","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C27,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["1f","Sensitive to, but not diagnostic of, EATS","Egg production","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C28,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["1g","Sensitive to, but not diagnostic of, EATS","Cracked eggs","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C29,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["1h","Sensitive to, but not diagnostic of, EATS","Egg viability (% viable embryo of egg set)","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C30,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["1i","Sensitive to, but not diagnostic of, EATS","Eggshell thickness","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C31,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["1j","Sensitive to, but not diagnostic of, EATS","Viable embryos","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C32,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["1k","Sensitive to, but not diagnostic of, EATS","Hatchability","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C33,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["1l","Sensitive to, but not diagnostic of, EATS","No of 14 day-old survivors","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C34,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["1m","Sensitive to, but not diagnostic of, EATS","Offspring body weight (bird)","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect",null,null,null,null,"N"]
["2b","Sensitive to, but not diagnostic of, EATS","Adult body weight (bird)","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect",null,null,null,null,"N"]
["2c","Sensitive to, but not diagnostic of, EATS","Clinical observations,  behaviour","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect",null,null,null,null,"N"]
["2d","Sensitive to, but not diagnostic of, EATS","Food consumption","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect",null,null,null,null,"N"]
["2e","Sensitive to, but not diagnostic of, EATS","Gross pathology (bird)","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C39,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["2f","Sensitive to, but not diagnostic of, EATS","Egg production","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C40,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["2g","Sensitive to, but not diagnostic of, EATS","Cracked eggs","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C41,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["2h","Sensitive to, but not diagnostic of, EATS","Egg viability (% viable embryo of egg set)","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C42,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["2i","Sensitive to, but not diagnostic of, EATS","Eggshell thickness","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C43,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["2j","Sensitive to, but not diagnostic of, EATS","Viable embryos","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C44,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["2k","Sensitive to, but not diagnostic of, EATS","Hatchability","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C45,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["2l","Sensitive to, but not diagnostic of, EATS","No of 14 day-old survivors","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C46,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["2m","Sensitive to, but not diagnostic of, EATS","Offspring body weight (bird)","Anas platyrhynchos",21,"weeks","Oral",2250,"ppm","Decrease",null,null,null,null,"N"]
["4b","Sensitive to, but not diagnostic of, EATS","Adult body weight (bird)","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect",null,null,null,null,"N"]
["4c","Sensitive to, but not diagnostic of, EATS","Food consumption","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect",null,null,null,null,"N"]
["4d","Sensitive to, but not diagnostic of, EATS","Egg production","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C50,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["4e","Sensitive to, but not diagnostic of, EATS","Cracked eggs","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C51,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["4f","Sensitive to, but not diagnostic of, EATS","Egg viability (% viable embryo of egg set)","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C52,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["4g","Sensitive to, but not diagnostic of, EATS","Eggshell thickness","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C53,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["4h","Sensitive to, but not diagnostic of, EATS","Egg weight","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C54,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["4i","Sensitive to, but not diagnostic of, EATS","Viable embryos","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C55,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["4j","Sensitive to, but not diagnostic of, EATS","Hatchability","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C56,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["4k","Sensitive to, but not diagnostic of, EATS","No of 14 day-old survivors","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C57,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["4l","Sensitive to, but not diagnostic of, EATS","Offspring body weight (bird)","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect",null,null,null,null,"N"]
["5b","Sensitive to, but not diagnostic of, EATS","Behaviour (fish):Lethargy","Brachydanio rerio",168,"hours","Uptake from water","3.2","mg/L","Increase",null,null,null,null,"N"]
["6a","Sensitive to, but not diagnostic of, EATS","Hatching success","Oncorhynchus mykiss","85 (60 post hatch)","days","Uptake from water","> 9.63","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C60,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["6b","Sensitive to, but not diagnostic of, EATS","Morphological abnormalities","Oncorhynchus mykiss","85 (60 post hatch)","days","Uptake from water","> 9.63","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C61,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["6c","Sensitive to, but not diagnostic of, EATS","Larval survival and length","Oncorhynchus mykiss","85 (60 post hatch)","days","Uptake from water","> 9.63","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C62,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["6d","Sensitive to, but not diagnostic of, EATS","Larval survival and length","Oncorhynchus mykiss","85 (60 post hatch)","days","Uptake from water","> 9.63","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C63,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["6e","Sensitive to, but not diagnostic of, EATS","Body weight (fish)","Oncorhynchus mykiss","85 (60 post hatch)","days","Uptake from water","> 9.63","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C64,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["7a","Sensitive to, but not diagnostic of, EATS","Hatching success","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C65,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["7c","Sensitive to, but not diagnostic of, EATS","Length (fish)","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C66,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["7d","Sensitive to, but not diagnostic of, EATS","Body weight (fish)","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C67,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["7e","Sensitive to, but not diagnostic of, EATS","Length (fish)","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C68,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["7f","Sensitive to, but not diagnostic of, EATS","Body weight (fish)","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C69,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["7g","Sensitive to, but not diagnostic of, EATS","Reproduction (fecundity, fertility)","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C70,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["7h","Sensitive to, but not diagnostic of, EATS","Hatching success","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C71,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["7j","Sensitive to, but not diagnostic of, EATS","Length (fish)","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C72,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["7k","Sensitive to, but not diagnostic of, EATS","Body weight (fish)","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C73,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["8b","Sensitive to, but not diagnostic of, EATS","Length (fish)","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C74,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["8c","Sensitive to, but not diagnostic of, EATS","Body weight (fish)","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C75,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["8d","Sensitive to, but not diagnostic of, EATS","Reproduction (fecundity, fertility)","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C76,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["8g","Sensitive to, but not diagnostic of, EATS","Gonado-somatic index","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C77,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["9b","Sensitive to, but not diagnostic of, EATS","Malformations","Xenopus laevis",21,"days","Uptake from water","> 90","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C78,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["9d","Sensitive to, but not diagnostic of, EATS","Body weight (amphibian)","Xenopus laevis",21,"days","Uptake from water",90,"mg/L","Increase",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C79,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["9e","Sensitive to, but not diagnostic of, EATS","Snout-vent length/growth","Xenopus laevis",21,"days","Uptake from water","4.3","mg/L","Increase",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C80,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["15a","Sensitive to, but not diagnostic of, EATS","Length (fish)","Gasterosteus aculeatus",42,"days","Uptake from water","> 100","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C81,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["15b","Sensitive to, but not diagnostic of, EATS","Body weight (fish)","Gasterosteus aculeatus",42,"days","Uptake from water","> 100","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C82,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"N"]
["16a","Sensitive to, but not diagnostic of, EATS","Emergence ratio of chironomids","Chironomus riparius",28,"days","Uptake from water","> 1000","mg/L","No effect",null,null,null,null,"N"]
["16b","Sensitive to, but not diagnostic of, EATS","Developmental rate of chironomids","Chironomus riparius",28,"days","Uptake from water","> 1000","mg/L","No effect",null,null,null,null,"N"]
["1a","Systemic toxicity","Mortality","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C85,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"-"]
["2a","Systemic toxicity","Mortality","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C86,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"-"]
["5a","Systemic toxicity","Survival (fish)","Brachydanio rerio",168,"hours","Uptake from water","3.2","mg/L","Decrease",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C87,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"-"]
["7b","Systemic toxicity","Survival (fish)","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C88,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"-"]
["7i","Systemic toxicity","Survival (fish)","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C89,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"-"]
["8a","Systemic toxicity","Survival (fish)","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C90,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"-"]
["9a","Systemic toxicity","Mortality (amphibian)","Xenopus laevis",21,"days","Uptake from water","> 90","mg/L","No effect",null,null,null,{"$f":"INDEX('Data summary_RMS'!$P$5:$AZ$5,1,MATCH(C91,'Data summary_RMS'!$P$7:$AZ$7,0))","v":1},"-"]
[null,""]
[null,""]

{"sheet":"Data_APPL","index":12,"n_rows":111,"n_cols":38,"rows_kept":111,"cut":false,"hidden":false,"merged":[]}
["Compound:","Glyphosate"]
["CAS:","1071-83-6 "]
["Comments:",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"E = Endpoints for estrogen-mediated activity"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"A = Endpoints for androgen-mediated activity"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"T = Endpoints for thyroid-related activity"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"S = Endpoints for steroidogenesisrelated activity"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"N = Endpoints potentially sensitive to, but not diagnostic of, EATS modalities"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"_ = Endpoints related to target organ toxicity and systemic toxicity"]
[]
[]
["Type of toxicity","Study principle","Study ID Matrix","Study reference ID"," Study guideline (OECD/US EPA) or remarks","Source","Reference (citation)","Reporting date","Species","Strain or in vitro model","Animals/sex/group","Sex (administration)","Purity (%)","Route of administration","Method of administration","Doses tested","Lowest dose tested","Highest dose tested","Dose unit","Duration of exposure","Duration unit","Generation/Life stage","Sex (effect dose)","Lowest Effect dose","Effect type","Effect target","Effect classification","Effect description","Effect determination","Effect direction","NOAEL/NOEL/NOEC","LOAEL/LOEL/LOEC","Unit","Effect indicative of","Additional remarks","Relevance","Reliability"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(Z12<>0,VLOOKUP(Z12,Interpretation!$C:$E,2,FALSE),\"\")","v":""},null,null,null,null,null,null,{"$f":"IF(Z12<>0,VLOOKUP(Z12,Interpretation!$C:$E,3,FALSE),\"\")","v":""}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(Z13<>0,VLOOKUP(Z13,Interpretation!$C:$E,2,FALSE),\"\")","v":""},null,null,null,null,null,null,{"$f":"IF(Z13<>0,VLOOKUP(Z13,Interpretation!$C:$E,3,FALSE),\"\")","v":""}]
["Avian","Avian reproduction test","1a","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Adult","M + F","> 2250","In life observation","Mortality",{"$f":"IF(Z14<>0,VLOOKUP(Z14,Interpretation!$C:$E,2,FALSE),\"\")","v":"Systemic toxicity"},"Mortality","Relative","No effect",2250,"> 2250","ppm",{"$f":"IF(Z14<>0,VLOOKUP(Z14,Interpretation!$C:$E,3,FALSE),\"\")","v":"_"},"After Week 19: \"hysteria attack\", 6 mortalities in control, 2 mortalities in each treatment","No","No"]
["Avian","Avian reproduction test","1b","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Adult","M + F","> 2250","In life observation","Body weight (bird)",{"$f":"IF(Z15<>0,VLOOKUP(Z15,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Body weight","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z15<>0,VLOOKUP(Z15,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"In Week 8: statistical increase in male bw at 500","No","No"]
["Avian","Avian reproduction test","1c","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Adult","M + F","> 2250","In life observation","[Not in list]","Sensitive to, but not diagnostic of, EATS","Clinical observations, behaviour","Absolute","No effect",2250,"> 2250","ppm","N",null,"No","No"]
["Avian","Avian reproduction test","1d","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Adult","M + F","> 2250","In life observation","[Not in list]","Sensitive to, but not diagnostic of, EATS","Feed consumption","Absolute","No effect",2250,"> 2250","ppm","N",null,"No","No"]
["Avian","Avian reproduction test","1e","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Adult","M + F","> 2250","Organ histopathology","Gross pathology (bird)",{"$f":"IF(Z18<>0,VLOOKUP(Z18,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Gross necropsy of survivors","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z18<>0,VLOOKUP(Z18,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"No","No"]
["Avian","Avian reproduction test","1f","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Adult","F","> 2250","Reproductive","Egg production",{"$f":"IF(Z19<>0,VLOOKUP(Z19,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Eggs/female divided by maximum laid","Relative","No effect",2250,"> 2250","ppm",{"$f":"IF(Z19<>0,VLOOKUP(Z19,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"No","No"]
["Avian","Avian reproduction test","1g","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Adult","F","> 2250","Reproductive","Cracked eggs",{"$f":"IF(Z20<>0,VLOOKUP(Z20,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Cracked eggs","Relative","No effect",2250,"> 2250","ppm",{"$f":"IF(Z20<>0,VLOOKUP(Z20,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"No","No"]
["Avian","Avian reproduction test","1h","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Adult","F","> 2250","Reproductive","Egg viability (% viable embryo of egg set)",{"$f":"IF(Z21<>0,VLOOKUP(Z21,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Candled at Day 11 or 12","Relative","No effect",2250,"> 2250","ppm",{"$f":"IF(Z21<>0,VLOOKUP(Z21,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"No","No"]
["Avian","Avian reproduction test","1i","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Adult","F","> 2250","Reproductive","Eggshell thickness",{"$f":"IF(Z22<>0,VLOOKUP(Z22,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Eggshell thickness","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z22<>0,VLOOKUP(Z22,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"No","No"]
["Avian","Avian reproduction test","1j","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Offspring (F1)","F","> 2250","Reproductive","Viable embryos",{"$f":"IF(Z23<>0,VLOOKUP(Z23,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Live embryos at Day 21","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z23<>0,VLOOKUP(Z23,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"No","No"]
["Avian","Avian reproduction test","1k","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Offspring (F1)","F","> 2250","Reproductive","Hatchability",{"$f":"IF(Z24<>0,VLOOKUP(Z24,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"of live 3-week embryos; of eggs set; of maximum set","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z24<>0,VLOOKUP(Z24,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"No","No"]
["Avian","Avian reproduction test","1l","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Offspring (F1)","M + F","> 2250","In life observation","No of 14 day-old survivors",{"$f":"IF(Z25<>0,VLOOKUP(Z25,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"of hatchlings; of eggs set; of maximum set","Relative","No effect",2250,"> 2250","ppm",{"$f":"IF(Z25<>0,VLOOKUP(Z25,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"No","No"]
["Avian","Avian reproduction test","1m","123-186","FIFRA 71-4, OECD 206","DAR",null,1999,"Colinus virginianus","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",20,"weeks","Offspring (F1)","M + F","> 2250","In life observation","Body weight (bird)",{"$f":"IF(Z26<>0,VLOOKUP(Z26,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"14-day old survivors","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z26<>0,VLOOKUP(Z26,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"No","No"]
["Avian","Avian reproduction test","2a","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","M + F","> 2250","In life observation","Mortality",{"$f":"IF(Z27<>0,VLOOKUP(Z27,Interpretation!$C:$E,2,FALSE),\"\")","v":"Systemic toxicity"},"Mortality","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z27<>0,VLOOKUP(Z27,Interpretation!$C:$E,3,FALSE),\"\")","v":"_"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2b","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","M + F","> 2250","In life observation","Body weight (bird)",{"$f":"IF(Z28<>0,VLOOKUP(Z28,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Body weight","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z28<>0,VLOOKUP(Z28,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2c","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","M + F","> 2250","In life observation","[Not in list]","Sensitive to, but not diagnostic of, EATS","Clinical observations, behaviour","Absolute","No effect",2250,"> 2250","ppm","N",null,"Yes","Yes"]
["Avian","Avian reproduction test","2d","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","M + F","> 2250","In life observation","[Not in list]","Sensitive to, but not diagnostic of, EATS","Feed consumption","Absolute","No effect",2250,"> 2250","ppm","N",null,"Yes","Yes"]
["Avian","Avian reproduction test","2e","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","M + F","> 2250","Organ histopathology","Gross pathology (bird)",{"$f":"IF(Z31<>0,VLOOKUP(Z31,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Gross necropsy of survivors","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z31<>0,VLOOKUP(Z31,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2f","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","F","> 2250","Reproductive","Egg production",{"$f":"IF(Z32<>0,VLOOKUP(Z32,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Eggs/female divided by maximum laid","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z32<>0,VLOOKUP(Z32,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2g","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","F","> 2250","Reproductive","Cracked eggs",{"$f":"IF(Z33<>0,VLOOKUP(Z33,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Cracked eggs","Relative","No effect",2250,"> 2250","ppm",{"$f":"IF(Z33<>0,VLOOKUP(Z33,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2h","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","F","> 2250","Reproductive","Egg viability (% viable embryo of egg set)",{"$f":"IF(Z34<>0,VLOOKUP(Z34,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Candled at Day 11 or 12","Relative","No effect",2250,"> 2250","ppm",{"$f":"IF(Z34<>0,VLOOKUP(Z34,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2i","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","F","> 2250","Reproductive","Eggshell thickness",{"$f":"IF(Z35<>0,VLOOKUP(Z35,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Eggshell thickness","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z35<>0,VLOOKUP(Z35,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2j","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","F","> 2250","Reproductive","Viable embryos",{"$f":"IF(Z36<>0,VLOOKUP(Z36,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Live embryos at Day 21","Relative","No effect",2250,"> 2250","ppm",{"$f":"IF(Z36<>0,VLOOKUP(Z36,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2k","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Adult","F","> 2250","Reproductive","Hatchability",{"$f":"IF(Z37<>0,VLOOKUP(Z37,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"of live 3-week embryos; of eggs set; of maximum set","Absolute","No effect",2250,"> 2250","ppm",{"$f":"IF(Z37<>0,VLOOKUP(Z37,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2l","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Offspring (F1)","M + F","> 2250","Reproductive","No of 14 day-old survivors",{"$f":"IF(Z38<>0,VLOOKUP(Z38,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Number of 14-day-old survivors ","Relative","No effect",2250,"> 2250","ppm",{"$f":"IF(Z38<>0,VLOOKUP(Z38,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","2m","123-187","FIFRA 71-4, OECD 206","DAR",null,1999,"Anas platyrhynchos","n.a.","32/F+M/group","M + F","95.6","Oral","Feed","500; 1000; 2250",500,2250,"ppm",21,"weeks","Offspring (F1)","M + F",2250,"In life observation","Body weight (bird)",{"$f":"IF(Z39<>0,VLOOKUP(Z39,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Body weight of 14 -day old survivors","Absolute","Decrease",1000,2250,"ppm",{"$f":"IF(Z39<>0,VLOOKUP(Z39,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"Significant decrease at 2250 ppm but at level of control of a different, parallel mallard study","Yes","Yes"]
["Avian","Avian reproduction test","3a","139-141","Not stated","DAR",null,1978,"Colinus virginianus","n.a.","36/M+F/group (1M+2F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",22,"weeks","Adult","F","> 1000","Reproductive","Egg production",{"$f":"IF(Z40<>0,VLOOKUP(Z40,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Number of eggs/hen","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z40<>0,VLOOKUP(Z40,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","3b","139-141","Not stated","DAR",null,1978,"Colinus virginianus","n.a.","36/M+F/group (1M+2F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",22,"weeks","Adult","F","> 1000","Reproductive","Cracked eggs",{"$f":"IF(Z41<>0,VLOOKUP(Z41,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Cracked eggs (Candled at Day 0)","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z41<>0,VLOOKUP(Z41,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","3c","139-141","Not stated","DAR",null,1978,"Colinus virginianus","n.a.","36/M+F/group (1M+2F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",22,"weeks","Adult","F","> 1000","Reproductive","Egg viability (% viable embryo of egg set)",{"$f":"IF(Z42<>0,VLOOKUP(Z42,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Egg viability ","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z42<>0,VLOOKUP(Z42,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","3d","139-141","Not stated","DAR",null,1978,"Colinus virginianus","n.a.","36/M+F/group (1M+2F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",22,"weeks","Adult","F",50,"Reproductive","Eggshell thickness",{"$f":"IF(Z43<>0,VLOOKUP(Z43,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Eggshell thickness","Absolute","Decrease",50,"< 50","ppm",{"$f":"IF(Z43<>0,VLOOKUP(Z43,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"↓ only at 50, not treatment-related","Yes","Yes"]
["Avian","Avian reproduction test","3e","139-141","Not stated","DAR",null,1978,"Colinus virginianus","n.a.","36/M+F/group (1M+2F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",22,"weeks","Adult","F",1000,"Reproductive","Egg weight","Sensitive to, but not diagnostic of, EATS","Egg weight","Absolute","Decrease",200,1000,"ppm","N","no standard endpoint in OECD 206","Yes","Yes"]
["Avian","Avian reproduction test","3f","139-141","Not stated","DAR",null,1978,"Colinus virginianus","n.a.","36/M+F/group (1M+2F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",22,"weeks","Adult","F","> 1000","Reproductive","Viable embryos",{"$f":"IF(Z45<>0,VLOOKUP(Z45,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Embryo viability (Candled at Day 14) ","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z45<>0,VLOOKUP(Z45,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","3g","139-141","Not stated","DAR",null,1978,"Colinus virginianus","n.a.","36/M+F/group (1M+2F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",22,"weeks","Adult","F","> 1000","Reproductive","Hatchability",{"$f":"IF(Z46<>0,VLOOKUP(Z46,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"of live 3-week embryos","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z46<>0,VLOOKUP(Z46,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","3k","139-141","Not stated","DAR",null,1978,"Colinus virginianus","n.a.","36/M+F/group (1M+2F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",22,"weeks","Offspring (F1)","M + F","> 1000","Reproductive","No of 14 day-old survivors",{"$f":"IF(Z47<>0,VLOOKUP(Z47,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"of normal hatchlings; per hen","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z47<>0,VLOOKUP(Z47,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","3l","139-141","Not stated","DAR",null,1978,"Colinus virginianus","n.a.","36/M+F/group (1M+2F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",22,"weeks","Offspring (F1)","M + F","> 1000","In life observation","Body weight (bird)",{"$f":"IF(Z48<>0,VLOOKUP(Z48,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Hatchlings, 14-day old survivors","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z48<>0,VLOOKUP(Z48,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","4b","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Adult","M + F","> 1000","In life observation","Body weight (bird)",{"$f":"IF(Z49<>0,VLOOKUP(Z49,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Body weight of hatchlings and 14-day old survivors","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z49<>0,VLOOKUP(Z49,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","4c","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Adult","M + F","> 1000","In life observation","[Not in list]","Sensitive to, but not diagnostic of, EATS","Feed consumption","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z50<>0,VLOOKUP(Z50,Interpretation!$C:$E,3,FALSE),\"\")","v":0},null,"Yes","Yes"]
["Avian","Avian reproduction test","4d","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Adult","F","> 1000","Reproductive","Egg production",{"$f":"IF(Z51<>0,VLOOKUP(Z51,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"No of eggs/hen","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z51<>0,VLOOKUP(Z51,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","4e","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Adult","F","> 1000","Reproductive","Cracked eggs",{"$f":"IF(Z52<>0,VLOOKUP(Z52,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Cracked eggs","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z52<>0,VLOOKUP(Z52,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","4f","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Adult","F","> 1000","Reproductive","Egg viability (% viable embryo of egg set)",{"$f":"IF(Z53<>0,VLOOKUP(Z53,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Egg viability","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z53<>0,VLOOKUP(Z53,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","4g","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Adult","F","> 1000","Reproductive","Eggshell thickness",{"$f":"IF(Z54<>0,VLOOKUP(Z54,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Eggshell thickness","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z54<>0,VLOOKUP(Z54,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","4h","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Adult","F","> 1000","Reproductive","Egg weight","Sensitive to, but not diagnostic of, EATS","Egg weight","Absolute","No effect",1000,"> 1000","ppm","N",null,"Yes","Yes"]
["Avian","Avian reproduction test","4i","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Adult","F","> 1000","Reproductive","Viable embryos",{"$f":"IF(Z56<>0,VLOOKUP(Z56,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Number of eggs set (Day 14); and thereof live 3-week embryos (Day 19)","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z56<>0,VLOOKUP(Z56,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","4j","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Adult","F","> 1000","Reproductive","Hatchability",{"$f":"IF(Z57<>0,VLOOKUP(Z57,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Number of living three-weeks embryos","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z57<>0,VLOOKUP(Z57,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","4k","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Offspring (F1)","M + F","> 1000","Reproductive","No of 14 day-old survivors",{"$f":"IF(Z58<>0,VLOOKUP(Z58,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"of normal hatchlings; per hen","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z58<>0,VLOOKUP(Z58,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Avian","Avian reproduction test","4l","139-143","Not stated","DAR",null,1978,"Anas platyrhynchos","n.a.","35/M+F/group (2M+5F/pen)","M + F",83,"Oral","Feed","50; 200; 1000",50,1000,"ppm",17,"weeks","Offspring (F1)","M + F","> 1000","In life observation","Body weight (bird)",{"$f":"IF(Z59<>0,VLOOKUP(Z59,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Hatchlings, 14-day old survivors","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z59<>0,VLOOKUP(Z59,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish Not il list","5a",null,"IBAMA 1990; OECD 212","DAR",null,2000,"Brachydanio rerio","n.a.","30/M+F/ group","M + F","954.9 g/kg acid equivalent","Uptake from water","Water","0.32; 0.56; 1.0; 3.2; 5.6; 10; 32","0.32",32,"mg/L",168,"hours","Larval","M + F","5.6","In life observation","Survival (fish)",{"$f":"IF(Z60<>0,VLOOKUP(Z60,Interpretation!$C:$E,2,FALSE),\"\")","v":"Systemic toxicity"},"Survival","Absolute","Decrease","3.2","5.6","mg/L",{"$f":"IF(Z60<>0,VLOOKUP(Z60,Interpretation!$C:$E,3,FALSE),\"\")","v":"_"},null,"Yes","Yes","Recommended duration of the test is 30 days according to OECD 212; yet RMS considers study as valid (RAR Oct 2015)"]
["Fish","Fish Not il list","5b",null,"IBAMA 1990; OECD 212","DAR",null,2000,"Brachydanio rerio","n.a.","30/M+F/ group","M + F","954.9 g/kg acid equivalent","Uptake from water","Water","0.32; 0.56; 1.0; 3.2; 5.6; 10; 32","0.32",32,"mg/L",168,"hours","Larval","M + F","3.2","In life observation","Behaviour (fish)",{"$f":"IF(Z61<>0,VLOOKUP(Z61,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Lethargy","Absolute","Increase",1,"3.2","mg/L",{"$f":"IF(Z61<>0,VLOOKUP(Z61,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"No statistics","Yes","Yes","Recommended duration of the test is 30 days according to OECD 212; yet RMS considers study as valid (RAR Oct 2015)"]
["Fish","Fish early life stage toxicity test","6a","2310941 /1005.029.321","OPPTS 850.1400; OECD 210","DAR",null,2010,"Oncorhynchus mykiss","n.a.","40/M+F/group","M + F","96.03","Uptake from water","Water","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","0.064","9.63","mg/L","85 (60 post hatch)","days","Embryo","M + F","> 9.63","In life observation","Hatching success",{"$f":"IF(Z62<>0,VLOOKUP(Z62,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Hatching success based on the number of eggs actually fertilized","Relative","No effect","9.63","> 9.63","mg/L",{"$f":"IF(Z62<>0,VLOOKUP(Z62,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish early life stage toxicity test","6b","2310941 /1005.029.321","OPPTS 850.1400; OECD 210","DAR",null,2010,"Oncorhynchus mykiss","n.a.","40/M+F/group","M + F","96.03","Uptake from water","Water","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","0.064","9.63","mg/L","85 (60 post hatch)","days","Embryo","M + F","> 9.63","Abnormalities","Morphological abnormalities",{"$f":"IF(Z63<>0,VLOOKUP(Z63,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Percent normal fry at hatch","Relative","No effect","9.63","> 9.63","mg/L",{"$f":"IF(Z63<>0,VLOOKUP(Z63,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish early life stage toxicity test","6c","2310941 /1005.029.321","OPPTS 850.1400; OECD 210","DAR",null,2010,"Oncorhynchus mykiss","n.a.","40/M+F/group","M + F","96.03","Uptake from water","Water","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","0.064","9.63","mg/L","85 (60 post hatch)","days","Larval","M + F","> 9.63","In life observation","Larval survival and length",{"$f":"IF(Z64<>0,VLOOKUP(Z64,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Survival of larvae 60 DPH","Relative","No effect","9.63","> 9.63","mg/L",{"$f":"IF(Z64<>0,VLOOKUP(Z64,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish early life stage toxicity test","6d","2310941 /1005.029.321","OPPTS 850.1400; OECD 210","DAR",null,2010,"Oncorhynchus mykiss","n.a.","40/M+F/group","M + F","96.03","Uptake from water","Water","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","0.064","9.63","mg/L","85 (60 post hatch)","days","Larval","M + F","> 9.63","In life observation","Larval survival and length",{"$f":"IF(Z65<>0,VLOOKUP(Z65,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Length of larvae 60 DPH","Absolute","No effect","9.63","> 9.63","mg/L",{"$f":"IF(Z65<>0,VLOOKUP(Z65,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish early life stage toxicity test","6e","2310941 /1005.029.321","OPPTS 850.1400; OECD 210","DAR",null,2010,"Oncorhynchus mykiss","n.a.","40/M+F/group","M + F","96.03","Uptake from water","Water","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","0.064","9.63","mg/L","85 (60 post hatch)","days","Larval","M + F","> 9.63","In life observation","Body weight (fish)",{"$f":"IF(Z66<>0,VLOOKUP(Z66,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Wet and dry weight of larvae 60 DPH","Absolute","No effect","9.63","> 9.63","mg/L",{"$f":"IF(Z66<>0,VLOOKUP(Z66,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish life cycle toxicity test","7a",null,"EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","60 eggs/group","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Embryo","M + F","> 25.7","Reproductive","Hatching success",{"$f":"IF(Z67<>0,VLOOKUP(Z67,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Hatching success","Relative","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z67<>0,VLOOKUP(Z67,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish life cycle toxicity test","7b",null,"EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","40/M+F/group","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Adult","M + F","> 25.7","In life observation","Survival (fish)",{"$f":"IF(Z68<>0,VLOOKUP(Z68,Interpretation!$C:$E,2,FALSE),\"\")","v":"Systemic toxicity"},"At days 30 and 60","Relative","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z68<>0,VLOOKUP(Z68,Interpretation!$C:$E,3,FALSE),\"\")","v":"_"},null,"Yes","Yes"]
["Fish","Fish life cycle toxicity test","7c",null,"EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","40/M+F/group","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Adult","M + F","> 25.7","In life observation","Length (fish)",{"$f":"IF(Z69<>0,VLOOKUP(Z69,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"At days 30 and 60","Absolute","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z69<>0,VLOOKUP(Z69,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish life cycle toxicity test","7d",null,"EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","40/M+F/group","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Adult","M + F","> 25.7","In life observation","Body weight (fish)",{"$f":"IF(Z70<>0,VLOOKUP(Z70,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"At days 30 and 60","Absolute","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z70<>0,VLOOKUP(Z70,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish life cycle toxicity test","7e",null,"EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","12/M+F/group (2M+4F/replicate)","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Adult","F","> 25.7","In life observation","Length (fish)",{"$f":"IF(Z71<>0,VLOOKUP(Z71,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"At test termination ","Absolute","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z71<>0,VLOOKUP(Z71,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish life cycle toxicity test","7f",null,"EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","12/M+F/group (2M+4F/replicate)","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Adult","F","> 25.7","In life observation","Body weight (fish)",{"$f":"IF(Z72<>0,VLOOKUP(Z72,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"At test termination ","Absolute","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z72<>0,VLOOKUP(Z72,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish life cycle toxicity test","7g",null,"EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","12/M+F/group (2M+4F/replicate)","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Adult","F","> 25.7","Reproductive","Reproduction (fecundity, fertility)",{"$f":"IF(Z73<>0,VLOOKUP(Z73,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Eggs/F, eggs/spawn","Absolute","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z73<>0,VLOOKUP(Z73,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish life cycle toxicity test","7h",null,"EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","50 eggs/group","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Offspring (F1)","F","> 25.7","Reproductive","Hatching success",{"$f":"IF(Z74<>0,VLOOKUP(Z74,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Hatching success","Relative","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z74<>0,VLOOKUP(Z74,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish life cycle toxicity test","7i",null,"EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","40 fry/group","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Offspring (F1)","M + F","> 25.7","In life observation","Survival (fish)",{"$f":"IF(Z75<>0,VLOOKUP(Z75,Interpretation!$C:$E,2,FALSE),\"\")","v":"Systemic toxicity"},"Offspring survival","Relative","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z75<>0,VLOOKUP(Z75,Interpretation!$C:$E,3,FALSE),\"\")","v":"_"},null,"Yes","Yes"]
["Fish","Fish life cycle toxicity test","7j",null,"EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","40 fry/group","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Offspring (F1)","M + F","> 25.7","In life observation","Length (fish)",{"$f":"IF(Z76<>0,VLOOKUP(Z76,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Offspring length","Absolute","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z76<>0,VLOOKUP(Z76,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish life cycle toxicity test","7k",null,"EPA 1971 Recommended bioassay procedures for fathead minnow chronic tests","DAR","Anonymous",1975,"Pimephales promelas","n.a.","40 fry/group","M + F","87.3","Uptake from water","Water","0.7; 2.8; 7; 13; 25.7 (mean measured)","0.7","25.7","mg/L",254,"days","Offspring (F1)","M + F","> 25.7","In life observation","Body weight (fish)",{"$f":"IF(Z77<>0,VLOOKUP(Z77,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Offspring body weight","Absolute","No effect","25.7","> 25.7","mg/L",{"$f":"IF(Z77<>0,VLOOKUP(Z77,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish short-term reproduction assay","8a","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","M + F","> 33","In life observation","Survival (fish)",{"$f":"IF(Z78<>0,VLOOKUP(Z78,Interpretation!$C:$E,2,FALSE),\"\")","v":"Systemic toxicity"},"Survival ","Relative","No effect",33,"> 33","mg/L",{"$f":"IF(Z78<>0,VLOOKUP(Z78,Interpretation!$C:$E,3,FALSE),\"\")","v":"_"},null,"Yes","Yes"]
["Fish","Fish short-term reproduction assay","8b","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","M + F","> 33","In life observation","Length (fish)",{"$f":"IF(Z79<>0,VLOOKUP(Z79,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Length","Absolute","No effect",33,"> 33","mg/L",{"$f":"IF(Z79<>0,VLOOKUP(Z79,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish short-term reproduction assay","8c","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","M + F","> 33","In life observation","Body weight (fish)",{"$f":"IF(Z80<>0,VLOOKUP(Z80,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Body weight","Absolute","No effect",33,"> 33","mg/L",{"$f":"IF(Z80<>0,VLOOKUP(Z80,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish short-term reproduction assay","8d","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","F","> 33","Reproductive","Reproduction (fecundity, fertility)",{"$f":"IF(Z81<>0,VLOOKUP(Z81,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Cumulative number of eggs/number of eggs per female reproductive day ","Absolute","No effect",33,"> 33","mg/L",{"$f":"IF(Z81<>0,VLOOKUP(Z81,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish short-term reproduction assay","8e","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","F","> 33","Reproductive","Male 2nd sex characteristics in females",{"$f":"IF(Z82<>0,VLOOKUP(Z82,Interpretation!$C:$E,2,FALSE),\"\")","v":"EATS-mediated"},"M: pigmentation patterns, tubercles, fatpads; F: ovipositors","Absolute","No effect",33,"> 33","mg/L",{"$f":"IF(Z82<>0,VLOOKUP(Z82,Interpretation!$C:$E,3,FALSE),\"\")","v":"A"},null,"Yes","Yes"]
["Fish","Fish short-term reproduction assay","8f","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","M","> 33","Reproductive","Male 2nd sex characteristics in males",{"$f":"IF(Z83<>0,VLOOKUP(Z83,Interpretation!$C:$E,2,FALSE),\"\")","v":"EATS-mediated"},"M: pigmentation patterns, tubercles, fatpads; F: ovipositors","Absolute","No effect",33,"> 33","mg/L",{"$f":"IF(Z83<>0,VLOOKUP(Z83,Interpretation!$C:$E,3,FALSE),\"\")","v":"E, A, S"},null,"Yes","Yes"]
["Fish","Fish short-term reproduction assay","8g","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","M + F","> 33","Reproductive","Gonado-somatic index",{"$f":"IF(Z84<>0,VLOOKUP(Z84,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"GSI","Absolute","No effect",33,"> 33","mg/L",{"$f":"IF(Z84<>0,VLOOKUP(Z84,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","Fish short-term reproduction assay","8h","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","F","> 33","Clinical chemistry/hormones","Vitellogenin (VTG) in females",{"$f":"IF(Z85<>0,VLOOKUP(Z85,Interpretation!$C:$E,2,FALSE),\"\")","v":"In vivo mechanistic"},"VTG in females","Absolute","No effect",33,"> 33","mg/L",{"$f":"IF(Z85<>0,VLOOKUP(Z85,Interpretation!$C:$E,3,FALSE),\"\")","v":"E, A, S"},"Non-significant ↓ in all treatments","Yes","Yes"]
["Fish","Fish short-term reproduction assay","8i","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","M","> 33","Clinical chemistry/hormones","Vitellogenin (VTG) in males",{"$f":"IF(Z86<>0,VLOOKUP(Z86,Interpretation!$C:$E,2,FALSE),\"\")","v":"In vivo mechanistic"},"VTG in males","Absolute","No effect",33,"> 33","mg/L",{"$f":"IF(Z86<>0,VLOOKUP(Z86,Interpretation!$C:$E,3,FALSE),\"\")","v":"E, A, S"},"Non-significant ↓ at 6.2 and 33 mg/L","Yes","Yes"]
["Fish","Fish short-term reproduction assay","8j","707A-102A","OPPTS 850.1350, OECD 229","DAR",null,2012,"Pimephales promelas","n.a.","24/M+F/group (2M+4F/replicate)","M + F","85.14","Uptake from water","Water","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","0.046",33,"mg/L",21,"days","Adult","M + F","> 33","Organ histopathology","Specific gonad histopathology",{"$f":"IF(Z87<>0,VLOOKUP(Z87,Interpretation!$C:$E,2,FALSE),\"\")","v":"EATS-mediated"},"Histopathology from testes and ovaries","Absolute","No effect",33,"> 33","mg/L",{"$f":"IF(Z87<>0,VLOOKUP(Z87,Interpretation!$C:$E,3,FALSE),\"\")","v":"E, A, S"},null,"Yes","Yes"]
["Amphibian","Amphibian metamorphosis assay","9a","707A-103","OPPTS 890.1100, OECD 231","DAR",null,2012,"Xenopus laevis","n.a.","80 tadpoles/M+F/ group","M + F","85.14","Uptake from water","Water","0.13; 0.79; 4.3; 20; 90 (mean measured)","0.13",90,"mg/L",21,"days","Tadpole","M + F","> 90","In life observation","Mortality (amphibian)",{"$f":"IF(Z88<>0,VLOOKUP(Z88,Interpretation!$C:$E,2,FALSE),\"\")","v":"Systemic toxicity"},"Mortality","Relative","No effect",90,"> 90","mg/L",{"$f":"IF(Z88<>0,VLOOKUP(Z88,Interpretation!$C:$E,3,FALSE),\"\")","v":"_"},null,"Yes","Yes"]
["Amphibian","Amphibian metamorphosis assay","9b","707A-103","OPPTS 890.1100, OECD 231","DAR",null,2012,"Xenopus laevis","n.a.","80 tadpoles/M+F/ group","M + F","85.14","Uptake from water","Water","0.13; 0.79; 4.3; 20; 90 (mean measured)","0.13",90,"mg/L",21,"days","Tadpole","M + F","> 90","Abnormalities","Malformations",{"$f":"IF(Z89<>0,VLOOKUP(Z89,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Malformations","Absolute","No effect",90,"> 90","mg/L",{"$f":"IF(Z89<>0,VLOOKUP(Z89,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"Tail curvature is considered as a dietary effect","Yes","Yes"]
["Amphibian","Amphibian metamorphosis assay","9c","707A-103","OPPTS 890.1100, OECD 231","DAR",null,2012,"Xenopus laevis","n.a.","80 tadpoles/M+F/ group","M + F","85.14","Uptake from water","Water","0.13; 0.79; 4.3; 20; 90 (mean measured)","0.13",90,"mg/L",21,"days","Tadpole","M + F","> 90","Developmental","Developmental stage",{"$f":"IF(Z90<>0,VLOOKUP(Z90,Interpretation!$C:$E,2,FALSE),\"\")","v":"EATS-mediated"},"Developmental stage","Absolute","No effect",90,"> 90","mg/L",{"$f":"IF(Z90<>0,VLOOKUP(Z90,Interpretation!$C:$E,3,FALSE),\"\")","v":"T"},null,"Yes","Yes"]
["Amphibian","Amphibian metamorphosis assay","9d","707A-103","OPPTS 890.1100, OECD 231","DAR",null,2012,"Xenopus laevis","n.a.","80 tadpoles/M+F/ group","M + F","85.14","Uptake from water","Water","0.13; 0.79; 4.3; 20; 90 (mean measured)","0.13",90,"mg/L",21,"days","Tadpole","M + F",90,"In life observation","Body weight (amphibian)",{"$f":"IF(Z91<>0,VLOOKUP(Z91,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Wet weight","Absolute","Increase",20,90,"mg/L",{"$f":"IF(Z91<>0,VLOOKUP(Z91,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"90 mg/L: Increase by 15% compared to control","Yes","Yes"]
["Amphibian","Amphibian metamorphosis assay","9e","707A-103","OPPTS 890.1100, OECD 231","DAR",null,2012,"Xenopus laevis","n.a.","80 tadpoles/M+F/ group","M + F","85.14","Uptake from water","Water","0.13; 0.79; 4.3; 20; 90 (mean measured)","0.13",90,"mg/L",21,"days","Tadpole","M + F","4.3","In life observation","Snout-vent length/growth",{"$f":"IF(Z92<>0,VLOOKUP(Z92,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Snout-vent length/growth","Absolute","Increase","0.79","4.3","mg/L",{"$f":"IF(Z92<>0,VLOOKUP(Z92,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"Snout-vent length: significantly increased by 5 and 7% at 4.3 and 90 mg/L and a significant trend (increase) by 2.5 % at 20 mg/L","Yes","Yes"]
["Amphibian","Amphibian metamorphosis assay","9f","707A-103","OPPTS 890.1100, OECD 231","DAR",null,2012,"Xenopus laevis","n.a.","80 tadpoles/M+F/ group","M + F","85.14","Uptake from water","Water","0.13; 0.79; 4.3; 20; 90 (mean measured)","0.13",90,"mg/L",21,"days","Tadpole","M + F","> 90","Developmental","Hind limb length",{"$f":"IF(Z93<>0,VLOOKUP(Z93,Interpretation!$C:$E,2,FALSE),\"\")","v":"EATS-mediated"},"Hind limb length","Absolute","No effect",90,"> 90","mg/L",{"$f":"IF(Z93<>0,VLOOKUP(Z93,Interpretation!$C:$E,3,FALSE),\"\")","v":"T"},null,"Yes","Yes"]
["Amphibian","Amphibian metamorphosis assay","9g","707A-103","OPPTS 890.1100, OECD 231","DAR",null,2012,"Xenopus laevis","n.a.","80 tadpoles/M+F/ group","M + F","85.14","Uptake from water","Water","0.13; 0.79; 4.3; 20; 90 (mean measured)","0.13",90,"mg/L",21,"days","Tadpole","M + F","> 90","Organ histopathology","Thyroid histopathology (amphibian)",{"$f":"IF(Z94<>0,VLOOKUP(Z94,Interpretation!$C:$E,2,FALSE),\"\")","v":"EATS-mediated"},"Thyroid histopathology","Absolute","No effect",90,"> 90","mg/L",{"$f":"IF(Z94<>0,VLOOKUP(Z94,Interpretation!$C:$E,3,FALSE),\"\")","v":"T"},null,"Yes","Yes"]
["[Toxicity test not in list]","[Toxicity test not in list]",10,250795,"OECD 202, part II","DAR",null,1990,"Daphnia magna","n.a.","10-20/F/group","F","98.7","Uptake from water","Water","3; 9.4; 30.0; 94.9;  300.0",3,300,"mg/L",21,"days","Adult","F","94.9","Reproductive","Reproduction (fecundity, fertility)",{"$f":"IF(Z95<>0,VLOOKUP(Z95,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Number of offspring per living adult","Absolute","Decrease",30,"94.9","mg/L",{"$f":"IF(Z95<>0,VLOOKUP(Z95,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["[Toxicity test not in list]","[Toxicity test not in list]","11a","80-91-2328-05-93","OECD 202, part II","DAR",null,1993,"Daphnia magna","n.a.","40/F/group","F","61.6 (Glyphosate isopropylamine salt)","Uptake from water","Water","43; 94; 207; 455; 1000",43,1000,"mg/L",21,"days","Adult","F",455,"In life observation","Mortality",{"$f":"IF(Z96<>0,VLOOKUP(Z96,Interpretation!$C:$E,2,FALSE),\"\")","v":"Systemic toxicity"},"Mortality","Relative","Increase",207,455,"mg/L",{"$f":"IF(Z96<>0,VLOOKUP(Z96,Interpretation!$C:$E,3,FALSE),\"\")","v":"_"},"Concentrations refer to product content","Yes","Yes"]
["[Toxicity test not in list]","[Toxicity test not in list]","11b","80-91-2328-05-93","OECD 202, part II","DAR",null,1993,"Daphnia magna","n.a.","40/F/group","F","61.6 (Glyphosate isopropylamine salt)","Uptake from water","Water","43; 94; 207; 455; 1000",43,1000,"mg/L",21,"days","Adult","F",207,"Reproductive","Reproduction (fecundity, fertility)",{"$f":"IF(Z97<>0,VLOOKUP(Z97,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"offspring per living adult and day","Absolute","Decrease",94,207,"mg/L",{"$f":"IF(Z97<>0,VLOOKUP(Z97,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"Concentrations refer to product content","Yes","Yes"]
["[Toxicity test not in list]","[Toxicity test not in list]","12a","091048056S","OECD 222","DAR",null,2009,"Eisenia fetida","n.a.","40-80/M+F/group","M + F","62 (Glyphosate isopropylamine salt)","Oral","Feed","30; 50; 100; 500;1000",30,1000,"ppm",56,"days","Adult","M + F","> 1000","In life observation","Body weight",{"$f":"IF(Z98<>0,VLOOKUP(Z98,Interpretation!$C:$E,2,FALSE),\"\")","v":"Systemic toxicity"},"Fresh weight after 4 weeks","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z98<>0,VLOOKUP(Z98,Interpretation!$C:$E,3,FALSE),\"\")","v":"_"},"Route of administration also dermal via whole body exposition, concentrations refer to product content","Yes","Yes"]
["[Toxicity test not in list]","[Toxicity test not in list]","12b","091048056S","OECD 222","DAR",null,2009,"Eisenia fetida","n.a.","40-80/M+F/group","M + F","62 (Glyphosate isopropylamine salt)","Dermal","Whole-Body","30; 50; 100; 500;1000",30,1000,"ppm",56,"days","Adult","M + F","> 1000","Reproductive","Reproduction (fecundity, fertility)",{"$f":"IF(Z99<>0,VLOOKUP(Z99,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Number of juvenile worms","Absolute","No effect",1000,"> 1000","ppm",{"$f":"IF(Z99<>0,VLOOKUP(Z99,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},"Concentrations refer to product content","Yes","Yes"]
["[Toxicity test not in list]","[Toxicity test not in list]","13a","091048058S","OECD 226","DAR",null,2009,"Hypoaspis aculeifer","n.a.","40-80/M+F/group","M + F","62 (Glyphosate isopropylamine salt)","Dermal","Whole-Body","23.64; 47.28; 236.4; 472.80","23.64","472.8","ppm",14,"days","Adult","M + F","> 472.8","In life observation","Mortality",{"$f":"IF(Z100<>0,VLOOKUP(Z100,Interpretation!$C:$E,2,FALSE),\"\")","v":"Systemic toxicity"},"Mortality","Relative","No effect",472.8,"> 472.8","ppm",{"$f":"IF(Z100<>0,VLOOKUP(Z100,Interpretation!$C:$E,3,FALSE),\"\")","v":"_"},null,"Yes","Yes"]
["[Toxicity test not in list]","[Toxicity test not in list]","13b","091048058S","OECD 226","DAR",null,2009,"Hypoaspis aculeifer","n.a.","40-80/M+F/group","M + F","62 (Glyphosate isopropylamine salt)","Dermal","Whole-Body","23.64; 47.28; 236.40; 472.80","23.64","472.8","ppm",14,"days","Adult","M + F","> 472.8","Reproductive","Reproduction (fecundity, fertility)",{"$f":"IF(Z101<>0,VLOOKUP(Z101,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"mean number of juveniles ","Absolute","No effect",472.8,"> 472.8","ppm",{"$f":"IF(Z101<>0,VLOOKUP(Z101,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["[Toxicity test not in list]","[Toxicity test not in list]","14a","091048057S","ISO 11267","DAR",null,2010,"Folsomia candida","n.a.","50/M+F/group","M + F","62 (Glyphosate isopropylamine salt)","Dermal","Whole-Body","19; 29; 59; 294; 587",19,587,"ppm",28,"days","Adult","M + F","> 587","In life observation","Mortality",{"$f":"IF(Z102<>0,VLOOKUP(Z102,Interpretation!$C:$E,2,FALSE),\"\")","v":"Systemic toxicity"},"Mortality ","Relative","No effect",587,"> 587","ppm",{"$f":"IF(Z102<>0,VLOOKUP(Z102,Interpretation!$C:$E,3,FALSE),\"\")","v":"_"},null,"Yes","Yes"]
["[Toxicity test not in list]","[Toxicity test not in list]","14b","091048057S","ISO 11267","DAR",null,2010,"Folsomia candida","n.a.","50/M+F/group","M + F","62 (Glyphosate isopropylamine salt)","Dermal","Whole-Body","19; 29; 59; 294; 587",19,587,"ppm",28,"days","Adult","M + F","> 587","Reproductive","Reproduction (fecundity, fertility)",{"$f":"IF(Z103<>0,VLOOKUP(Z103,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Number of juveniles","Absolute","No effect",587,"> 587","ppm",{"$f":"IF(Z103<>0,VLOOKUP(Z103,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","[Toxicity test not in list]","15a",null,"Not stated","publication","Le Mer, C. et al. ",2013,"Gasterosteus aculeatus","n.a.","27-30/M+F/group","M + F","≥  96","Uptake from water","Water","0.1; 1; 10; 100","0.1","100","mg/L",42,"days","Juvenile","M + F","> 100","In life observation","Length (fish)",{"$f":"IF(Z104<>0,VLOOKUP(Z104,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Fish length","Absolute","No effect","≥ 100","> 100","mg/L",{"$f":"IF(Z104<>0,VLOOKUP(Z104,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","[Toxicity test not in list]","15b",null,"Not stated","publication","Le Mer, C. et al. ",2013,"Gasterosteus aculeatus","n.a.","27-30/M+F/group","M + F","≥  96","Uptake from water","Water","0.1; 1; 10; 100","0.1","100","mg/L",42,"days","Juvenile","M + F","> 100","In life observation","Body weight (fish)",{"$f":"IF(Z105<>0,VLOOKUP(Z105,Interpretation!$C:$E,2,FALSE),\"\")","v":"Sensitive to, but not diagnostic of, EATS"},"Fish wet weight","Absolute","No effect","≥ 100","> 100","mg/L",{"$f":"IF(Z105<>0,VLOOKUP(Z105,Interpretation!$C:$E,3,FALSE),\"\")","v":"N"},null,"Yes","Yes"]
["Fish","[Toxicity test not in list]","15c",null,"Not stated","publication","Le Mer, C. et al. ",2013,"Gasterosteus aculeatus","n.a.","27-30/M+F/group","M + F","≥  96","Uptake from water","Water","0.1; 1; 10; 100","0.1","100","mg/L",42,"days","Juvenile","M + F","> 100","Clinical chemistry/hormones","[Not in list]","In vivo mechanistic","VTG induction in fish","Not reported","No effect","≥ 100","> 100","mg/L","E, A, S","Fish were pooled for VTG analysis. No differentiation between males and females.","Yes","Yes"]
["Fish","[Toxicity test not in list]","15d",null,"Not stated","publication","Le Mer, C. et al. ",2013,"Gasterosteus aculeatus","n.a.","27-30/M+F/group","M + F","≥  96","Uptake from water","Water","0.1; 1; 10; 100","0.1","100","mg/L",42,"days","Juvenile","M + F","> 100","Reproductive","Sex ratio","EATS-mediated","Sex ratio in juvenile fish","Not reported","No effect","≥ 100","> 100","mg/L","E, A, S","Evaluated by gonad histology.","Yes","Yes"]
["Fish","[Toxicity test not in list]","15e",null,"Not stated","publication","Le Mer, C. et al. ",2013,"Gasterosteus aculeatus","n.a.","27-30/M+F/group","M + F","≥  96","Uptake from water","Water","0.1; 1; 10; 100","0.1","100","mg/L",42,"days","Juvenile","M + F","> 100","Clinical chemistry/hormones","Spiggin",{"$f":"IF(Z108<>0,VLOOKUP(Z108,Interpretation!$C:$E,2,FALSE),\"\")","v":"In vivo mechanistic"},"Spiggin in juvenile fish","Not reported","No effect","≥ 100","> 100","mg/L","A","No induction of spiggin was observed in the positive dihydrotestosterone control. Therefore, the results on spiggin induction are considered as not reliable and not considered within the further evaluation.","Yes","No"]
["[Toxicity test not in list]","[Toxicity test not in list]","16a","20FV2ME","OECD 219","DAR",null,2020,"Chironomus riparius","n.a.","160/M+F/group","M + F","97.7","Uptake from water","Water","100; 1000","100","100","mg/L",28,"days","Adult","M + F","> 1000","In life observation","[Not in list]","Sensitive to, but not diagnostic of, EATS","Emergence ratio of chironomids","Relative","No effect","≥ 1000","> 1000","mg/L","N",null,"Yes","Yes"]
["[Toxicity test not in list]","[Toxicity test not in list]","16b","20FV2ME","OECD 219","DAR",null,2020,"Chironomus riparius","n.a.","160/M+F/group","M + F","97.7","Uptake from water","Water","100; 1000","100","100","mg/L",28,"days","Adult","M + F","> 1000","In life observation","[Not in list]","Sensitive to, but not diagnostic of, EATS","Developmental rate of chironomids","Absolute","No effect","≥ 1000","> 1000","mg/L","N",null,"Yes","Yes"]
["[Toxicity test not in list]","[Toxicity test not in list]","16c","20FV2ME","OECD 219","DAR",null,2020,"Chironomus riparius","n.a.","160/M+F/group","M + F","97.7","Uptake from water","Water","100; 1000",100,"100","mg/L",28,"days","Adult","M + F","> 1000","In life observation","Sex ratio","EATS-mediated","Sex ratio in chironomids","Relative","No effect","≥ 1000","> 1000","mg/L","N",null,"Yes","Yes"]

{"sheet":"Data summary-APPL","index":13,"n_rows":110,"n_cols":52,"rows_kept":110,"cut":false,"hidden":false,"merged":[[3,15,3,51],[107,0,107,14],[108,0,108,14],[109,0,109,14]]}
[]
[]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Insert a sorting number (1 .. n) on targets loading as lines of evidence"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,36,37,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"In vivo mechanistic","In vivo mechanistic","In vivo mechanistic","In vivo mechanistic","EATS-mediated","EATS-mediated","EATS-mediated","EATS-mediated","EATS-mediated","EATS-mediated","EATS-mediated","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Sensitive to, but not diagnostic of, EATS","Systemic toxicity","Systemic toxicity","Systemic toxicity","Systemic toxicity"]
["Study ID Matrix","Source","Year","Type of toxicity","Study Principle","Species","Doses tested","Dose unit","Route of administration","Exposure","Exposure unit","Generation/Life stage","Additional remarks","Relevance","Reliability","[Not in list]","Spiggin","Vitellogenin (VTG) in females","Vitellogenin (VTG) in males","Developmental stage","Hind limb length","Male 2nd sex characteristics in females","Male 2nd sex characteristics in males","Sex ratio","Specific gonad histopathology","Thyroid histopathology (amphibian)","[Not in list]","Behaviour (fish)","Body weight (amphibian)","Body weight (bird)","Body weight (fish)","Cracked eggs","Egg production","Egg viability (% viable embryo of egg set)","Egg weight","Eggshell thickness","Gonado-somatic index","Gross pathology (bird)","Hatchability","Hatching success","Larval survival and length","Length (fish)","Malformations","Morphological abnormalities","No of 14 day-old survivors","Reproduction (fecundity, fertility)","Snout-vent length/growth","Viable embryos","Body weight","Mortality","Mortality (amphibian)","Survival (fish)"]
["5a","DAR",2000,"Fish","Fish Not il list","Brachydanio rerio","0.32; 0.56; 1.0; 3.2; 5.6; 10; 32","mg/L","Uptake from water",168,"hours","Larval",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Decrease 5.6 (Survival, Absolute)"]
["5b","DAR",2000,"Fish","Fish Not il list","Brachydanio rerio","0.32; 0.56; 1.0; 3.2; 5.6; 10; 32","mg/L","Uptake from water",168,"hours","Larval","No statistics","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,"Increase 3.2 (Lethargy, Absolute)"]
["15a","publication",2013,"Fish","[Toxicity test not in list]","Gasterosteus aculeatus","0.1; 1; 10; 100","mg/L","Uptake from water",42,"days","Juvenile",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 100 (Fish length, Absolute)"]
["15b","publication",2013,"Fish","[Toxicity test not in list]","Gasterosteus aculeatus","0.1; 1; 10; 100","mg/L","Uptake from water",42,"days","Juvenile",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 100 (Fish wet weight, Absolute)"]
["15c","publication",2013,"Fish","[Toxicity test not in list]","Gasterosteus aculeatus","0.1; 1; 10; 100","mg/L","Uptake from water",42,"days","Juvenile","Fish were pooled for VTG analysis. No differentiation between males and females.","Yes","Yes","No effect > 100 (VTG induction in fish, Not reported)"]
["15d","publication",2013,"Fish","[Toxicity test not in list]","Gasterosteus aculeatus","0.1; 1; 10; 100","mg/L","Uptake from water",42,"days","Juvenile","Evaluated by gonad histology.","Yes","Yes",null,null,null,null,null,null,null,null,"No effect > 100 (Sex ratio in juvenile fish, Not reported)"]
["15e","publication",2013,"Fish","[Toxicity test not in list]","Gasterosteus aculeatus","0.1; 1; 10; 100","mg/L","Uptake from water",42,"days","Juvenile","No induction of spiggin was observed in the positive dihydrotestosterone control. Therefore, the results on spiggin induction are considered as not reliable and not considered within the further evaluation.","Yes","No",null,"No effect > 100 (Spiggin in juvenile fish, Not reported)"]
["6a","DAR",2010,"Fish","Fish early life stage toxicity test","Oncorhynchus mykiss","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","mg/L","Uptake from water","85 (60 post hatch)","days","Embryo",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 9.63 (Hatching success based on the number of eggs actually fertilized, Relative)"]
["6b","DAR",2010,"Fish","Fish early life stage toxicity test","Oncorhynchus mykiss","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","mg/L","Uptake from water","85 (60 post hatch)","days","Embryo",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 9.63 (Percent normal fry at hatch, Relative)"]
["6c","DAR",2010,"Fish","Fish early life stage toxicity test","Oncorhynchus mykiss","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","mg/L","Uptake from water","85 (60 post hatch)","days","Larval",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 9.63 (Survival of larvae 60 DPH, Relative)"]
["6d","DAR",2010,"Fish","Fish early life stage toxicity test","Oncorhynchus mykiss","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","mg/L","Uptake from water","85 (60 post hatch)","days","Larval",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 9.63 (Length of larvae 60 DPH, Absolute)"]
["6e","DAR",2010,"Fish","Fish early life stage toxicity test","Oncorhynchus mykiss","0.064; 0.261; 0.846; 2.804; 9.63 (mean measured)","mg/L","Uptake from water","85 (60 post hatch)","days","Larval",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 9.63 (Wet and dry weight of larvae 60 DPH, Absolute)"]
["7a","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Embryo",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (Hatching success, Relative)"]
["7b","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (At days 30 and 60, Relative)"]
["7c","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (At days 30 and 60, Absolute)"]
["7d","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (At days 30 and 60, Absolute)"]
["7e","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (At test termination , Absolute)"]
["7f","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (At test termination , Absolute)"]
["7g","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (Eggs/F, eggs/spawn, Absolute)"]
["7h","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Offspring (F1)",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (Hatching success, Relative)"]
["7i","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Offspring (F1)",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (Offspring survival, Relative)"]
["7j","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Offspring (F1)",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (Offspring length, Absolute)"]
["7k","DAR",1975,"Fish","Fish life cycle toxicity test","Pimephales promelas","0.7; 2.8; 7; 13; 25.7 (mean measured)","mg/L","Uptake from water",254,"days","Offspring (F1)",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 25.7 (Offspring body weight, Absolute)"]
["8a","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 33 (Survival , Relative)"]
["8b","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 33 (Length, Absolute)"]
["8c","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 33 (Body weight, Absolute)"]
["8d","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 33 (Cumulative number of eggs/number of eggs per female reproductive day , Absolute)"]
["8e","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,"No effect > 33 (M: pigmentation patterns, tubercles, fatpads; F: ovipositors, Absolute)"]
["8f","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,"No effect > 33 (M: pigmentation patterns, tubercles, fatpads; F: ovipositors, Absolute)"]
["8g","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 33 (GSI, Absolute)"]
["8h","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult","Non-significant ↓ in all treatments","Yes","Yes",null,null,"No effect > 33 (VTG in females, Absolute)"]
["8i","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult","Non-significant ↓ at 6.2 and 33 mg/L","Yes","Yes",null,null,null,"No effect > 33 (VTG in males, Absolute)"]
["8j","DAR",2012,"Fish","Fish short-term reproduction assay","Pimephales promelas","0.046; 0.23; 1.2; 6.2; 33 (mean measured)","mg/L","Uptake from water",21,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,"No effect > 33 (Histopathology from testes and ovaries, Absolute)"]
["9a","DAR",2012,"Amphibian","Amphibian metamorphosis assay","Xenopus laevis","0.13; 0.79; 4.3; 20; 90 (mean measured)","mg/L","Uptake from water",21,"days","Tadpole",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 90 (Mortality, Relative)"]
["9b","DAR",2012,"Amphibian","Amphibian metamorphosis assay","Xenopus laevis","0.13; 0.79; 4.3; 20; 90 (mean measured)","mg/L","Uptake from water",21,"days","Tadpole","Tail curvature is considered as a dietary effect","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 90 (Malformations, Absolute)"]
["9c","DAR",2012,"Amphibian","Amphibian metamorphosis assay","Xenopus laevis","0.13; 0.79; 4.3; 20; 90 (mean measured)","mg/L","Uptake from water",21,"days","Tadpole",null,"Yes","Yes",null,null,null,null,"No effect > 90 (Developmental stage, Absolute)"]
["9d","DAR",2012,"Amphibian","Amphibian metamorphosis assay","Xenopus laevis","0.13; 0.79; 4.3; 20; 90 (mean measured)","mg/L","Uptake from water",21,"days","Tadpole","90 mg/L: Increase by 15% compared to control","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,"Increase 90 (Wet weight, Absolute)"]
["9e","DAR",2012,"Amphibian","Amphibian metamorphosis assay","Xenopus laevis","0.13; 0.79; 4.3; 20; 90 (mean measured)","mg/L","Uptake from water",21,"days","Tadpole","Snout-vent length: significantly increased by 5 and 7% at 4.3 and 90 mg/L and a significant trend (increase) by 2.5 % at 20 mg/L","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Increase 4.3 (Snout-vent length/growth, Absolute)"]
["9f","DAR",2012,"Amphibian","Amphibian metamorphosis assay","Xenopus laevis","0.13; 0.79; 4.3; 20; 90 (mean measured)","mg/L","Uptake from water",21,"days","Tadpole",null,"Yes","Yes",null,null,null,null,null,"No effect > 90 (Hind limb length, Absolute)"]
["9g","DAR",2012,"Amphibian","Amphibian metamorphosis assay","Xenopus laevis","0.13; 0.79; 4.3; 20; 90 (mean measured)","mg/L","Uptake from water",21,"days","Tadpole",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,"No effect > 90 (Thyroid histopathology, Absolute)"]
["2a","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Mortality, Absolute)"]
["2b","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Body weight, Absolute)"]
["2c","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Clinical observations, behaviour, Absolute)"]
["2d","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Feed consumption, Absolute)"]
["2e","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Gross necropsy of survivors, Absolute)"]
["2f","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Eggs/female divided by maximum laid, Absolute)"]
["2g","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Cracked eggs, Relative)"]
["2h","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Candled at Day 11 or 12, Relative)"]
["2i","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Eggshell thickness, Absolute)"]
["2j","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Live embryos at Day 21, Relative)"]
["2k","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (of live 3-week embryos; of eggs set; of maximum set, Absolute)"]
["2l","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Offspring (F1)",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Number of 14-day-old survivors , Relative)"]
["2m","DAR",1999,"Avian","Avian reproduction test","Anas platyrhynchos","500; 1000; 2250","ppm","Oral",21,"weeks","Offspring (F1)","Significant decrease at 2250 ppm but at level of control of a different, parallel mallard study","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Decrease 2250 (Body weight of 14 -day old survivors, Absolute)"]
["4b","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Body weight of hatchlings and 14-day old survivors, Absolute)"]
["4c","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Feed consumption, Absolute)"]
["4d","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (No of eggs/hen, Absolute)"]
["4e","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Cracked eggs, Absolute)"]
["4f","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Egg viability, Absolute)"]
["4g","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Eggshell thickness, Absolute)"]
["4h","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Egg weight, Absolute)"]
["4i","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Number of eggs set (Day 14); and thereof live 3-week embryos (Day 19), Absolute)"]
["4j","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Number of living three-weeks embryos, Absolute)"]
["4k","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Offspring (F1)",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (of normal hatchlings; per hen, Absolute)"]
["4l","DAR",1978,"Avian","Avian reproduction test","Anas platyrhynchos","50; 200; 1000","ppm","Oral",17,"weeks","Offspring (F1)",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Hatchlings, 14-day old survivors, Absolute)"]
["1a","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Adult","After Week 19: \"hysteria attack\", 6 mortalities in control, 2 mortalities in each treatment","No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Mortality, Relative)"]
["1b","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Adult","In Week 8: statistical increase in male bw at 500","No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Body weight, Absolute)"]
["1c","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Adult",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Clinical observations, behaviour, Absolute)"]
["1d","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Adult",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Feed consumption, Absolute)"]
["1e","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Adult",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Gross necropsy of survivors, Absolute)"]
["1f","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Adult",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Eggs/female divided by maximum laid, Relative)"]
["1g","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Adult",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Cracked eggs, Relative)"]
["1h","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Adult",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Candled at Day 11 or 12, Relative)"]
["1i","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Adult",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Eggshell thickness, Absolute)"]
["1j","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Offspring (F1)",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (Live embryos at Day 21, Absolute)"]
["1k","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Offspring (F1)",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (of live 3-week embryos; of eggs set; of maximum set, Absolute)"]
["1l","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Offspring (F1)",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (of hatchlings; of eggs set; of maximum set, Relative)"]
["1m","DAR",1999,"Avian","Avian reproduction test","Colinus virginianus","500; 1000; 2250","ppm","Oral",20,"weeks","Offspring (F1)",null,"No","No",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 2250 (14-day old survivors, Absolute)"]
["3a","DAR",1978,"Avian","Avian reproduction test","Colinus virginianus","50; 200; 1000","ppm","Oral",22,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Number of eggs/hen, Absolute)"]
["3b","DAR",1978,"Avian","Avian reproduction test","Colinus virginianus","50; 200; 1000","ppm","Oral",22,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Cracked eggs (Candled at Day 0), Absolute)"]
["3c","DAR",1978,"Avian","Avian reproduction test","Colinus virginianus","50; 200; 1000","ppm","Oral",22,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Egg viability , Absolute)"]
["3d","DAR",1978,"Avian","Avian reproduction test","Colinus virginianus","50; 200; 1000","ppm","Oral",22,"weeks","Adult","↓ only at 50, not treatment-related","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Decrease 50 (Eggshell thickness, Absolute)"]
["3e","DAR",1978,"Avian","Avian reproduction test","Colinus virginianus","50; 200; 1000","ppm","Oral",22,"weeks","Adult","no standard endpoint in OECD 206","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Decrease 1000 (Egg weight, Absolute)"]
["3f","DAR",1978,"Avian","Avian reproduction test","Colinus virginianus","50; 200; 1000","ppm","Oral",22,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Embryo viability (Candled at Day 14) , Absolute)"]
["3g","DAR",1978,"Avian","Avian reproduction test","Colinus virginianus","50; 200; 1000","ppm","Oral",22,"weeks","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (of live 3-week embryos, Absolute)"]
["3k","DAR",1978,"Avian","Avian reproduction test","Colinus virginianus","50; 200; 1000","ppm","Oral",22,"weeks","Offspring (F1)",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (of normal hatchlings; per hen, Absolute)"]
["3l","DAR",1978,"Avian","Avian reproduction test","Colinus virginianus","50; 200; 1000","ppm","Oral",22,"weeks","Offspring (F1)",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Hatchlings, 14-day old survivors, Absolute)"]
["16a","DAR",2020,"[Toxicity test not in list]","[Toxicity test not in list]","Chironomus riparius","100; 1000","mg/L","Uptake from water",28,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Emergence ratio of chironomids, Relative)"]
["16b","DAR",2020,"[Toxicity test not in list]","[Toxicity test not in list]","Chironomus riparius","100; 1000","mg/L","Uptake from water",28,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Developmental rate of chironomids, Absolute)"]
["16c","DAR",2020,"[Toxicity test not in list]","[Toxicity test not in list]","Chironomus riparius","100; 1000","mg/L","Uptake from water",28,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,"No effect > 1000 (Sex ratio in chironomids, Relative)"]
[10,"DAR",1990,"[Toxicity test not in list]","[Toxicity test not in list]","Daphnia magna","3; 9.4; 30.0; 94.9;  300.0","mg/L","Uptake from water",21,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Decrease 94.9 (Number of offspring per living adult, Absolute)"]
["11a","DAR",1993,"[Toxicity test not in list]","[Toxicity test not in list]","Daphnia magna","43; 94; 207; 455; 1000","mg/L","Uptake from water",21,"days","Adult","Concentrations refer to product content","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Increase 455 (Mortality, Relative)"]
["11b","DAR",1993,"[Toxicity test not in list]","[Toxicity test not in list]","Daphnia magna","43; 94; 207; 455; 1000","mg/L","Uptake from water",21,"days","Adult","Concentrations refer to product content","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Decrease 207 (offspring per living adult and day, Absolute)"]
["12a","DAR",2009,"[Toxicity test not in list]","[Toxicity test not in list]","Eisenia fetida","30; 50; 100; 500;1000","ppm","Oral",56,"days","Adult","Route of administration also dermal via whole body exposition, concentrations refer to product content","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Fresh weight after 4 weeks, Absolute)"]
["12b","DAR",2009,"[Toxicity test not in list]","[Toxicity test not in list]","Eisenia fetida","30; 50; 100; 500;1000","ppm","Dermal",56,"days","Adult","Concentrations refer to product content","Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 1000 (Number of juvenile worms, Absolute)"]
["14a","DAR",2010,"[Toxicity test not in list]","[Toxicity test not in list]","Folsomia candida","19; 29; 59; 294; 587","ppm","Dermal",28,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 587 (Mortality , Relative)"]
["14b","DAR",2010,"[Toxicity test not in list]","[Toxicity test not in list]","Folsomia candida","19; 29; 59; 294; 587","ppm","Dermal",28,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 587 (Number of juveniles, Absolute)"]
["13a","DAR",2009,"[Toxicity test not in list]","[Toxicity test not in list]","Hypoaspis aculeifer","23.64; 47.28; 236.4; 472.80","ppm","Dermal",14,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 472.8 (Mortality, Relative)"]
["13b","DAR",2009,"[Toxicity test not in list]","[Toxicity test not in list]","Hypoaspis aculeifer","23.64; 47.28; 236.40; 472.80","ppm","Dermal",14,"days","Adult",null,"Yes","Yes",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No effect > 472.8 (mean number of juveniles , Absolute)"]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"[Not in list]","Spiggin","Vitellogenin (VTG) in females","Vitellogenin (VTG) in males","Developmental stage","Hind limb length","Male 2nd sex characteristics in females","Male 2nd sex characteristics in males","Sex ratio","Specific gonad histopathology","Thyroid histopathology (amphibian)","[Not in list]","Behaviour (fish)","Body weight (amphibian)","Body weight (bird)","Body weight (fish)","Cracked eggs","Egg production","Egg viability (% viable embryo of egg set)","Egg weight","Eggshell thickness","Gonado-somatic index","Gross pathology (bird)","Hatchability","Hatching success","Larval survival and length","Length (fish)","Malformations","Morphological abnormalities","No of 14 day-old survivors","Reproduction (fecundity, fertility)","Snout-vent length/growth","Viable embryos","Body weight","Mortality","Mortality (amphibian)","Survival (fish)"]
["Effect",null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,2,1,0,0,1,0,1]
["No effect",null,null,null,null,null,null,null,null,null,null,null,null,null,null,1,1,1,1,1,1,1,1,2,1,1,7,0,0,6,6,4,4,4,1,3,1,2,4,3,2,5,1,1,4,5,0,4,1,4,1,3]
["Not classified",null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]

{"sheet":"LoE-Adversity_APPL","index":14,"n_rows":88,"n_cols":14,"rows_kept":88,"cut":false,"hidden":false,"merged":[[85,10,87,10],[85,11,87,11],[1,12,87,12],[85,13,86,13],[74,10,75,10],[22,10,25,10],[19,10,20,10],[16,10,17,10],[26,10,27,10],[28,10,29,10],[58,10,61,10],[30,10,34,10],[35,10,37,10],[52,10,55,10],[56,10,57,10],[78,11,80,11],[78,13,80,13],[1,13,21,13],[22,13,25,13],[26,13,28,13],[30,13,73,13],[74,13,75,13],[26,11,29,11],[30,11,75,11],[81,11,82,11],[83,11,84,11],[1,10,12,10],[1,11,25,11],[13,10,15,10],[78,10,80,10],[62,10,73,10],[42,10,45,10],[38,10,41,10],[46,10,47,10],[48,10,51,10],[76,11,77,11]]}
["Study ID Matrix","Effect classification","Effect target","Species","Duration of exposure","Duration unit","Route of administration","Lowest Effect dose","Dose unit","Effect direction","Observed effect (positive and negative)","Assessment of each line of evidence","Assessment on the integrated line of evidence","Modality"]
["6e","Sensitive to, but not diagnostic of, EATS","Body weight (fish)","Oncorhynchus mykiss","85 (60 post hatch)","days","Uptake from water","> 9.63","mg/L","No effect","No effect on fish growth and Gonado-somatic index up to highest test concentrations (9.63 - 100 mg/L) in three GLP studies and one publication.","In fish: Mostly no effects; very few systemic effects (mortality) or secondary effects (only in a range where systemic effects already occur).","No evidence for adversity observed.","N"]
["7d","Sensitive to, but not diagnostic of, EATS","Body weight (fish)","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect"]
["7f","Sensitive to, but not diagnostic of, EATS","Body weight (fish)","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect"]
["7k","Sensitive to, but not diagnostic of, EATS","Body weight (fish)","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect"]
["8c","Sensitive to, but not diagnostic of, EATS","Body weight (fish)","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect"]
["7c","Sensitive to, but not diagnostic of, EATS","Length (fish)","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect"]
["7e","Sensitive to, but not diagnostic of, EATS","Length (fish)","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect"]
["7j","Sensitive to, but not diagnostic of, EATS","Length (fish)","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect"]
["8b","Sensitive to, but not diagnostic of, EATS","Length (fish)","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect"]
["8g","Sensitive to, but not diagnostic of, EATS","Gonado-somatic index","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect"]
["15b","Sensitive to, but not diagnostic of, EATS","Body weight (fish)","Gasterosteus aculeatus",42,"days","Uptake from water","> 100","mg/L","No effect"]
["15a","Sensitive to, but not diagnostic of, EATS","Length (fish)","Gasterosteus aculeatus",42,"days","Uptake from water","> 100","mg/L","No effect"]
["6a","Sensitive to, but not diagnostic of, EATS","Hatching success","Onorhynchus mykiss","85 (60 post hatch)","days","Uptake from water","> 9.63","mg/L","No effect","No effect on fish hatching success up to highest test concentrations (9.63 and 25.7 mg/L) in 2 studies."]
["7a","Sensitive to, but not diagnostic of, EATS","Hatching success","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect"]
["7h","Sensitive to, but not diagnostic of, EATS","Hatching success","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect"]
["6c","Sensitive to, but not diagnostic of, EATS","Larval survival and length","Oncorhynchus mykiss","85 (60 post hatch)","days","Uptake from water","> 9.63","mg/L","No effect","No effect on fish survival and length up to highest test concentration (9.63 mg/L)."]
["6d","Sensitive to, but not diagnostic of, EATS","Larval survival and length","Oncorhynchus mykiss","85 (60 post hatch)","days","Uptake from water","> 9.63","mg/L","No effect"]
["6b","Sensitive to, but not diagnostic of, EATS","Morphological abnormalities","Oncorhynchus mykiss","85 (60 post hatch)","days","Uptake from water","> 9.63","mg/L","No effect","No morphological abnormalities up to highest test concentration (9.63 mg/L)."]
["7g","Sensitive to, but not diagnostic of, EATS","Reproduction (fecundity, fertility)","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect","No effect on fish reproduction up to the highest test concentrations (25.7 and 33 mg/L) in 2 studies."]
["8d","Sensitive to, but not diagnostic of, EATS","Reproduction (fecundity, fertility)","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect"]
["5b","Sensitive to, but not diagnostic of, EATS","Behaviour (fish): Lethargy","Brachydanio rerio",168,"hours","Uptake from water","3.2","mg/L","Increase","Systemic effect (secondary to systemic toxicity: Adverse effect on fish behaviour  observed in only one study; effect occurs in the same concentration with increased mortality at the same concentration range (5.6 mg/L)."]
["5a","Systemic toxicity","Survival (fish)","Brachydanio rerio",168,"hours","Uptake from water","5.6","mg/L","Deacrease","Decrease in fish survival only observed in one study. No effects on survival up to the highest test concentrations (25.7 - 33 mg/L.)",null,null,"_"]
["7b","Systemic toxicity","Survival (fish)","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect"]
["7i","Systemic toxicity","Survival (fish)","Pimephales promelas",254,"days","Uptake from water","> 25.7","mg/L","No effect"]
["8a","Systemic toxicity","Survival (fish)","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect"]
["9d","Sensitive to, but not diagnostic of, EATS","Body weight (amphibian)","Xenopus laevis",21,"days","Uptake from water",90,"mg/L","Increase","Slight increase in amphibian growth.","In amphibians: No adverse effects observed. The slight increase in amphibian growth is not cosidered to be T-mediated since no effects are observed on developmental stage, hind limb length or thyroid histopathology. ",null,"N"]
["9e","Sensitive to, but not diagnostic of, EATS","Snout-vent length/growth","Xenopus laevis",21,"days","Uptake from water","4.3","mg/L","Increase"]
["9b","Sensitive to, but not diagnostic of, EATS","Malformations","Xenopus laevis",21,"days","Uptake from water","> 90","mg/L","No effect","No effect on amphibian malformations and mortality up to the highest concentration (90 mg/L.)"]
["9a","Systemic toxicity","Mortality (amphibian)","Xenopus laevis",21,"days","Uptake from water","> 90","mg/L","No effect",null,null,null,"_"]
["1c","Sensitive to, but not diagnostic of, EATS","Clinical observations,  behaviour","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect","No effect on avian behaviour and food consumption up to the highest test doses (1000 and 2250 ppm) in 3 studies.","In birds: No significant adverse effects observed in 4 studies.",null,"N"]
["2c","Sensitive to, but not diagnostic of, EATS","Clinical observations, behaviour","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect"]
["1d","Sensitive to, but not diagnostic of, EATS","Feed consumption","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect"]
["2d","Sensitive to, but not diagnostic of, EATS","Food consumption","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect"]
["4c","Sensitive to, but not diagnostic of, EATS","Food consumption","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect"]
["1b","Sensitive to, but not diagnostic of, EATS","Adult body weight (bird)","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect","No effect on avian adult body weight up the highest test doses (1000 and 2250 ppm) in 3 studies. "]
["2b","Sensitive to, but not diagnostic of, EATS","Adult body weight (bird)","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect"]
["4b","Sensitive to, but not diagnostic of, EATS","Adult body weight (bird)","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect"]
["1f","Sensitive to, but not diagnostic of, EATS","Egg production","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect","No effect on avian reproduction up to the highest test doses (1000 and 2250 ppm) in 4 studies.  "]
["2f","Sensitive to, but not diagnostic of, EATS","Egg production","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect"]
["3a","Sensitive to, but not diagnostic of, EATS","Egg production","Colinus virginianus",22,"weeks","Oral","> 1000","ppm","No effect"]
["4d","Sensitive to, but not diagnostic of, EATS","Egg production","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect"]
["1m","Sensitive to, but not diagnostic of, EATS","Offspring body weight (bird)","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect","Decreased avian offspring body weight at the highest test dose of 2250 ppm in only 1 of 4 studies. No effects on offspring body weight up to the highest test doses (1000 and 2250 ppm) in 3 studies."]
["2m","Sensitive to, but not diagnostic of, EATS","Offspring body weight (bird)","Anas platyrhynchos",21,"weeks","Oral",2250,"ppm","Decrease"]
["3l","Sensitive to, but not diagnostic of, EATS","Offspring body weight (bird)","Colinus virginianus",22,"weeks","Oral","> 1000","ppm","No effect"]
["4l","Sensitive to, but not diagnostic of, EATS","Offspring body weight (bird)","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect"]
["3e","Sensitive to, but not diagnostic of, EATS","Egg weight","Colinus virginianus",22,"weeks","Oral",1000,"ppm","Decrease","Decreased avian egg weight at the highest test concentration of 1000 ppm in 1 of 2 studies. This effect is not reflected by a decreased offspring body weight in the same study and can be considered as negligible."]
["4h","Sensitive to, but not diagnostic of, EATS","Egg weight","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect"]
["1g","Sensitive to, but not diagnostic of, EATS","Cracked eggs","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect","No effect on avian egg-shell breaking strength up to highest test doses (1000 and 2250 ppm) in 4 studies."]
["2g","Sensitive to, but not diagnostic of, EATS","Cracked eggs","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect"]
["3b","Sensitive to, but not diagnostic of, EATS","Cracked eggs","Colinus virginianus",22,"weeks","Oral","> 1000","ppm","No effect"]
["4e","Sensitive to, but not diagnostic of, EATS","Cracked eggs","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect"]
["1i","Sensitive to, but not diagnostic of, EATS","Eggshell thickness","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect","Avian eggshell thickness is not affected in a dose-dependent pattern in 4 studies. The decrease in study ID 3 only occurred at a dose of 50 ppm and not at higher doses."]
["2i","Sensitive to, but not diagnostic of, EATS","Eggshell thickness","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect"]
["3d","Sensitive to, but not diagnostic of, EATS","Eggshell thickness","Colinus virginianus",22,"weeks","Oral",50,"ppm","Decrease"]
["4g","Sensitive to, but not diagnostic of, EATS","Eggshell thickness","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect"]
["1e","Sensitive to, but not diagnostic of, EATS","Gross pathology (bird)","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect","No effect on avian gross pathology up to the highest test dose (2250 ppm) in 2 studies."]
["2e","Sensitive to, but not diagnostic of, EATS","Gross pathology (bird)","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect"]
["1k","Sensitive to, but not diagnostic of, EATS","Hatchability","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect","No effect on avian offspring hatchability up to the highest test doses (1000 and 2250 ppm) in 3 studies."]
["2k","Sensitive to, but not diagnostic of, EATS","Hatchability","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect"]
["3g","Sensitive to, but not diagnostic of, EATS","Hatchability","Colinus virginianus",22,"weeks","Oral","> 1000","ppm","No effect"]
["4j","Sensitive to, but not diagnostic of, EATS","Hatchability","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect"]
["1h","Sensitive to, but not diagnostic of, EATS","Egg viability (% viable embryo of egg set)","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect","No effect on avian egg viability or offspring survival in 2 bird species up to the highest test doses (1000 and 2250 ppm) in 4 studies."]
["2h","Sensitive to, but not diagnostic of, EATS","Egg viability (% viable embryo of egg set)","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect"]
["3c","Sensitive to, but not diagnostic of, EATS","Egg viability (% viable embryo of egg set)","Colinus virginianus",22,"weeks","Oral","> 1000","ppm","No effect"]
["4f","Sensitive to, but not diagnostic of, EATS","Egg viability (% viable embryo of egg set)","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect"]
["1l","Sensitive to, but not diagnostic of, EATS","Number of 14 day-old survivors","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect"]
["2l","Sensitive to, but not diagnostic of, EATS","Number of 14 day-old survivors","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect"]
["3k","Sensitive to, but not diagnostic of, EATS","Number of 14 day-old survivors","Colinus virginianus",22,"weeks","Oral","> 1000","ppm","No effect"]
["4k","Sensitive to, but not diagnostic of, EATS","Number of 14 day-old survivors","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect"]
["1j","Sensitive to, but not diagnostic of, EATS","Viable embryos","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect"]
["2j","Sensitive to, but not diagnostic of, EATS","Viable embryos","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect"]
["3f","Sensitive to, but not diagnostic of, EATS","Viable embryos","Colinus virginianus",22,"weeks","Oral","> 1000","ppm","No effect"]
["4i","Sensitive to, but not diagnostic of, EATS","Viable embryos","Anas platyrhynchos",17,"weeks","Oral","> 1000","ppm","No effect"]
["1a","Systemic toxicity","Mortality","Colinus virginianus",20,"weeks","Oral","> 2250","ppm","No effect","No mortality in birds observed  up to the highest test concentrations (2250 and 1000 ppm) in 2 studies.",null,null,"_"]
["2a","Systemic toxicity","Mortality","Anas platyrhynchos",21,"weeks","Oral","> 2250","ppm","No effect"]
["12a","Systemic toxicity","Body weight","Eisenia fetida",56,"days","Oral","> 1000","ppm","No effect","No effect on earthworm reproduction observed up to the highest test concentration (1000 ppm).","In Eisenia: No adverse effects observed.",null,"_"]
["12b","Sensitive to, but not diagnostic of, EATS","Reproduction (fecundity, fertility)","Eisenia fetida",56,"days","Dermal","> 1000","ppm","No effect","No mortality observed in earthworms.",null,null,"N"]
[10,"Sensitive to, but not diagnostic of, EATS","Reproduction (fecundity, fertility)","Daphnia magna",21,"days","Uptake from water","94.9","mg/L","Decrease","Decrease of  daphnid mortality and reproduction (considered as systemic effects).","In Daphnia: Effects on reproduction are considered to be a secondary effect (systemic effect).",null,"_"]
["11b","Sensitive to, but not diagnostic of, EATS","Reproduction (fecundity, fertility)","Daphnia magna",21,"days","Uptake from water",207,"mg/L","Decrease"]
["11a","Systemic toxicity","Mortality","Daphnia magna",21,"days","Uptake from water",455,"mg/L","Increase"]
["13b","Sensitive to, but not diagnostic of, EATS","Reproduction (fecundity, fertility)","Hypoaspis aculeifer",14,"days","Dermal","> 472.8","ppm","No effect","No effect on mite reproduction observed up to the highest test concentration (472.8 ppm).","In Hypoaspis: No adverse effects observed.",null,"N"]
["13a","Systemic toxicity","Mortality","Hypoaspis aculeifer",14,"days","Dermal","> 472.8","ppm","No effect","No mortality observed in mites.",null,null,"_"]
["14b","Sensitive to, but not diagnostic of, EATS","Reproduction (fecundity, fertility)","Folsomia candida",28,"days","Dermal","> 587","ppm","No effect","No effect on springtail reproduction observed.","In Folsomia: No adverse effects observed.",null,"N"]
["14a","Systemic toxicity","Mortality","Folsomia candida",28,"days","Dermal","> 587","ppm","No effect","No mortality observed springtails.",null,null,"_"]
["16a","Sensitive to, but not diagnostic of, EATS","Emergence ratio of chironomids","Chironomus riparius",28,"days","Uptake from water","> 1000","other","No effect","No effect on chironomid  development and sex ratio observed up to the highest test concentration (1000 mg/L).","In Chironomus: No adverse effects observed.",null,"N"]
["16b","Sensitive to, but not diagnostic of, EATS","Developmental rate of chironomids","Chironomus riparius",28,"days","Uptake from water","> 1000","other","No effect"]
["16c","EATS-mediated","Sex ratio in chironomids","Chironomus riparius",28,"days","Uptake from water","> 1000","other","No effect",null,null,null,"E, A, S"]

{"sheet":"LOE-EAS activity_APPL","index":15,"n_rows":9,"n_cols":14,"rows_kept":9,"cut":false,"hidden":false,"merged":[[3,5,4,5],[3,6,4,6],[3,7,4,7],[3,8,4,8],[3,9,4,9],[3,0,4,0],[3,1,4,1],[3,2,4,2],[3,3,4,3],[3,4,4,4],[1,13,2,13],[5,10,7,10],[1,10,4,10],[1,11,4,11],[6,13,8,13],[5,11,8,11]]}
["Study ID Matrix","Effect classification","Effect target","Species","Duration of exposure","Duration unit","Route of administration","Lowest Effect dose","Dose unit","Effect direction","Observed effect (positive and negative)","Assessment of each line of evidence","Assessment on the integrated line of evidence","Modality"]
["8h","In vivo mechanistic","Vitellogenin (VTG) in females","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect","No effect on VTG content in males and females in a concentration up to the highest test concentration (33 and 100 mg/L) one GLP study and one published study.","Sufficiently investigated according to ED Guidance:\nNo evidence for effects on VTG content in fish.","Sufficiently investigated according to ED Guidance: No evidence for EAS- mediated activity observed.","E, A, S"]
["8i","In vivo mechanistic","Vitellogenin (VTG) in males","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect"]
["15c","In vivo mechanistic","VTG induction in fish","Gasterosteus aculeatus",42,"days","Uptake from water","> 100","mg/L","No effect",null,null,null,"E, A, S"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,"E"]
["8e","EATS-mediated","Male 2nd sex characteristics in females","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect","No histopathological effects or effects on male 2nd sex characteristics in female and male fish in a concentration range of 0.046 - 33 mg/L.","Sufficiently investigated according to ED Guidance: No evidence for EAS-mediated activity in fish (histopathology, 2nd sex characteristics).",null,"A"]
["8f","EATS-mediated","Male 2nd sex characteristics in males","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect",null,null,null,"E, A, S"]
["8j","EATS-mediated","Specific gonad histopathology","Pimephales promelas",21,"days","Uptake from water","> 33","mg/L","No effect"]
["15d","EATS-mediated","Sex ratio","Gasterosteus aculeatus",42,"days","Uptake from water","> 100","mg/L","No effect","No effects on fish sex ratio"]

{"sheet":"LoE-T activity_APPL","index":16,"n_rows":4,"n_cols":14,"rows_kept":4,"cut":false,"hidden":false,"merged":[[1,10,3,10],[1,13,3,13],[1,11,3,11],[1,12,3,12]]}
["Study ID Matrix","Effect classification","Effect target","Species","Duration of exposure","Duration unit","Route of administration","Lowest Effect dose","Dose unit","Effect direction","Observed effect (positive and negative)","Assessment of each line of evidence","Assessment on the integrated line of evidence","Modality"]
["9c","EATS-mediated","Developmental stage","Xenopus laevis",21,"days","Uptake from water","> 90","mg/L","No effect","No effect on T-mediated parameters up to the highest test concentration  (90 mg/L)","Sufficiently investigated according to ED Guidance: No evidence for EAS-mediated activity in amphibians (development, histopathology)","Sufficiently investigated according to ED Guidance: No evidence for T- mediated activity observed.","T"]
["9f","EATS-mediated","Hind limb length","Xenopus laevis",21,"days","Uptake from water","> 90","mg/L","No effect"]
["9g","EATS-mediated","Thyroid histopathology (amphibian)","Xenopus laevis",21,"days","Uptake from water","> 90","mg/L","No effect"]