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Transparency on safety aspects and use of glyphosate-containing herbicides in Europe

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Webinar: The genotoxic potential of glyphosate – is glyphosate to be linked with oxidative stress?

November 10, 4:00 PM – 6:00 PM CET

If you have any questions or comments on the webinar, please do not hesitate to contact us.

In 2015, the International Agency for the Research on Cancer (IARC) categorised the active substance glyphosate as a ‘Category 2A’ probable human carcinogen.  Subsequent reviews by regulatory agencies around the world (EFSA, Food and Safety Commission of Japan, US EPA, New Zealand EPA and Australian Pesticides and Veterinary Medicines Authority) and the WHO’s Joint Meeting on Pesticide Residues recently issued evaluations contradicting IARC. The alleged mode of action responsible for glyphosate’s ‘probable’ carcinogenicity is genotoxicity and more specifically: the mechanism of ‘oxidative stress’.
During this webinar Prof. David Kirkland and Dr. James Bus will assess the scientific arguments at hand and will host a scientific discussion on glyphosate and genotoxicity. While Prof. Kirkland will primarily focus on the evidence available in the vast amount of standard genotoxicity studies, Dr. Bus will focus on the plausibility of the mechanism of oxidative stress.

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Speaker biographies:

David Kirkland was formerly Vice President of Scientific and Regulatory Consulting at Covance, Harrogate, where he was responsible for the pharmaceutical regulatory affairs group and expert reviews, with particular emphasis on genetic toxicology.  In 2009 he left Covance to work as an independent genetic toxicology consultant. He has a BSc in microbiology (University of London) and a PhD on cell transformation studies (Imperial Cancer Research Fund, awarded by Brunel University).   Following two post-doctoral fellowships at the Institute of Cancer Research (London) he spent 30 years in contract research, at Toxicol Laboratories and Microtest Research Limited which later become part of Covance.  He has extensive experience with regulatory issues relating to genotoxicity data; he has written numerous publications and is a regular podium speaker/chairperson.

He has received several awards:

  • Fellowship of the UK Environmental Mutagen Society (2002)
  • Honorary Professorship of the University of Wales, Swansea (2006)
  • The first Industrial Genotoxicity Group (UKEMS) Distinguished Toxicologist Award (2010)
  • The US Environmental Mutagen Society Alexander Hollaender Award (2010) for scientific contributions to the field of genetic toxicology and for global leadership in the regulation of toxicology testing
  • The Kitashi Mochizuki Award by the Japanese Environmental Mutagen Society (2014) for promotion of international harmonization of genotoxicity tests through the International Workshops on Genotoxicity Testing (IWGT) of which he was chair of the steering committee for 20 years.
  • The Jim Parry award for outstanding contributions to the field of environmental mutagenesis, UKEMS, 2015.

He was Special Issues Editor for Mutation Research, editorial board member of the Journal of Applied Toxicology, past president of the European Environmental Mutagen and Genomics Society (EEMGS) and UKEMS, and a former councilor of US EMGS. David is a member of the UK Government Advisory Committee on Mutagenicity (UK COM), and a member of the Steering Committee of the ILSI/HESI Genetic Toxicology Technical Committee.

Dr. James Bus has over 35 years of toxicology experience of research and evidence-based literature analyses informing potential health risks  associated with chemical and pesticide exposures. He offers chemical specific and strategic toxicology expertise addressing development, stewardship, and regulatory needs to individual industry clients and business consortia and government and non-governmental agencies. Expertise in design, implementation, and interpretation of toxicity tests and mode of action and dose response/exposure evaluations furthering translation of toxicology findings to risk assessment.  Expertise includes target-organ and endpoint-specific modes of action, and specific toxicity of chemicals including chlorinated organics, ethylene glycol and glycol ethers, aromatic derivatives benzene, styrene, Aniline and others, and pesticides such as 2,4-D (http://www.exponent.com/professionals/b/bus-james).

During this webinar Prof. David Kirkland and Dr. James Bus will assess the scientific arguments at hand and will host a scientific discussion on glyphosate and genotoxicity. While Prof. Kirkland will primarily focus on the evidence available in the vast amount of standard genotoxicity studies, Dr. Bus will focus on the plausibility of the mechanism of oxidative stress.
 

Last update: 16 December 2016