Glyphosate Facts

Transparency on safety aspects and use of glyphosate-containing herbicides in Europe


EPA: glyphosate does not induce mutations

The US Environmental Protection Agency (EPA) held its Scientific Advisory Panel (SAP) 13-16 December 2016 regarding EPA’s Evaluation of the Carcinogenic Potential of Glyphosate.

The EPA concluded  that “the overall weight of evidence indicates that there is no convincing evidence that glyphosate induces mutations in vivo via the oral route. When administered by i.p. injection, the micronucleus studies were predominantly negative. In the two cases where an increase in micronuclei were reported via this route, the effects occurred above the reported i.p. LD50 for mice and were not observed in other i.p. injection studies at similar or higher doses. While there is limited genotoxic evidence for effects in some in vitro experiments, in vivo effects were given more weight than in vitro effects particularly when the same genetic endpoint was measured, which is consistent with current OECD guidance. The only positive findings reported in vivo were seen at relatively high doses that are not relevant for human health risk assessment.”


Background information:

The details and documents including the draft issue paper and comments from stakeholders can be found on this link.

Presentations and inputs made at the SAP made by the local entities of members of the Glyphosate Task Force can be found here:

Background comments from industry can be found on the following links:

Last update: 23 December 2016